Maryland is currently home to 2680 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others
NCT01193075
Recruiting
This is an observational longitudinal study to determine the natural history and genotype-phenotype correlations of disease causing mutations in Charcot Marie Tooth disease (CMT) type 1B (CMT1B), 2A (CMT2A), 4A (CMT4A), and 4C (CMT4C). The investigators will also be determine the capability of the newly developed CMT Pediatric Scale (CMT Peds scale) and the Minimal Dataset to measure impairment and perform longitudinal measurements in patients with multiple forms of CMT over a five year window
Gender:
ALL
Ages:
All
Trial Updated:
05/09/2024
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Charcot Marie Tooth Disease
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An Assessment of Cognitive Improvement Training Among Mid-life Individuals
NCT03501706
Recruiting
Many health-relevant decisions involve intertemporal (now vs. later) tradeoffs. Extensive literature indicates that many negative health and financial consequences suffered in mid-life are linked to adversity and disadvantage during early developmental periods of life. Individuals who continue to engage in these types of unhealthy behaviors despite awareness of the health consequences are exhibiting an inability to delay gratification. Delay discounting (DD) is quantified in human studies by de... Read More
Gender:
ALL
Ages:
Between 40 years and 60 years
Trial Updated:
05/08/2024
Locations: University of Kansas-Lawrence, Baltimore, Maryland
Conditions: Delay Discounting
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Retinal Blood Flow and Autoregulation
NCT05344274
Recruiting
The purpose of this study is to establish autoregulation of retinal blood flow in arterioles and capillaries as a biomarker for early primary open angle glaucoma.
Gender:
ALL
Ages:
Between 18 years and 88 years
Trial Updated:
05/06/2024
Locations: University of Maryland Faculty Physicians, Inc, Baltimore, Maryland
Conditions: Glaucoma
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Bioresorbable Glass Fiber Matrix in the Treatment of Diabetic Foot Ulcers
NCT06403605
Recruiting
This study is a prospective, multi-center, randomized controlled trial designed to collect patient outcome data on 2 commercially available SOC treatments for Diabetic Foot Wounds.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/03/2024
Locations: Foot and Ankle Specialists of the Mid Atlantic, Frederick, Maryland
Conditions: Diabetic Foot Ulcer, Ulcer Foot, Diabetic Foot
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Relationship Between Data Obtained With the LuGENE® Multiparameter Transcriptomics Blood Test and Clinical and Standard Laboratory Features of Patients With SLE (ReLATE)
NCT05845593
Recruiting
This is an open label study to determine the association of the data obtained with LuGENE®, a transcriptomic-based LDT, with standard evaluation of patients diagnosed with SLE, including clinical involvement, SLEDAI score, Physician Global Assessment (PGA) and standard laboratory measures, including ANA, anti-DNA, anti-RNP and complement components C3 and C4, as well as Patient Reported Outcomes capturing pain, fatigue and Health-Related Quality of Life. The test will be administered on one occa... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/01/2024
Locations: University of Maryland School of Medicine, Baltimore, Maryland
Conditions: Lupus Erythematosus, Systemic
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Study of Navtemadlin as Maintenance Therapy in TP53WT Advanced or Recurrent Endometrial Cancer
NCT05797831
Recruiting
This study evaluates navtemadlin as maintenance treatment for patients with advanced or recurrent endometrial cancer (EC) who have achieved complete response or partial response on chemotherapy. The study will be conducted in 2 parts. Part 1 will evaluate safety and efficacy of two different doses of navtemadlin alongside an observational control arm to determine the Phase 3 navtemadlin dose. Part 2 will evaluate the efficacy and safety of navtemadlin Phase 3 dose compared to placebo.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/30/2024
Locations: Maryland Oncology Hematology, P.A., Silver Spring, Maryland
Conditions: Endometrial Cancer
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Tender Loving Care for Recurrent Pregnancy Loss
NCT06182878
Recruiting
The goal of this investigational study is to evaluate participation in a weekly, interactive, tender loving care messaging platform impact on pregnancy outcomes in patients with recurrent pregnancy loss. The main questions it aims to answer are: (1) does participation in weekly, interactive tender loving care messages increase live birth rates in patients with recurrent pregnancy loss? (2) Does participation in weekly, interactive tender loving care messages increase patients' quality of life?... Read More
Gender:
FEMALE
Ages:
Between 18 years and 44 years
Trial Updated:
04/29/2024
Locations: Walter Reed National Military Medical Center, Bethesda, Maryland
Conditions: Recurrent Pregnancy Loss
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[Lu-177]Ludotadipep in Castration-resistant Prostate Cancer(CRPC): Investigation of Drug and Application
NCT05458544
Recruiting
Phase 1: The objective of the Phase 1 part of the clinical trial is to verify safety and tolerability (dose-limiting toxicity \[DLT\], maximum tolerated dose \[MTD\]) of a single 3.7 Giga-Becquerel (GBq) dose with the potential for one dose level de-escalation to 2.775 GBq if necessary, to determine the recommended \[177Lu\]Ludotadipep dose for use in the Phase 2a part of the trial. Phase 2a: The objective of the Phase 2a part of the trial is to evaluate safety and efficacy for repeated adminis... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
04/25/2024
Locations: University of Maryland, Baltimore, Maryland
Conditions: Metastatic Castration-resistant Prostate Cancer
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Phase 2 Trial of HY209gel in Atopic Dermatitis Patients
NCT06024499
Recruiting
This is a randomized, double-blind, placebo-controlled, multi-center, phase 2 study in patients with mild to moderate Atopic Dermatitis(AD), which consists of 2 parts.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
04/24/2024
Locations: Continental Clinical Solutions, LLC, Towson, Maryland
Conditions: Atopic Dermatitis, Atopic Dermatitis Eczema, Atopic Dermatitis of Scalp
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Acoustic Stimulation During Restricted Sleep After Sleep Deprivation
NCT05309473
Recruiting
The purpose of this study is to determine if brief sounds or tones presented within a restricted period of recovery sleep after a period of sleep deprivation will enhance restorative properties and improve performance during a subsequent period of wakefulness.
Gender:
ALL
Ages:
Between 18 years and 39 years
Trial Updated:
04/22/2024
Locations: Walter Reed Army Institute of Research, Silver Spring, Maryland
Conditions: Sleep Deprivation, Sleep Restriction, Acoustic Stimulation, Performance, Alertness
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Ancora-SB Overtube Complete Positioning and Optical Visualization During Endoscopic Procedures
NCT06111131
Recruiting
Demonstrate superiority of the Aspero Medical Ancora-SB balloon Overtube compared to the Olympus ST-SB1 Balloon Overtube.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
04/18/2024
Locations: University of Maryland, Baltimore, Maryland
Conditions: Small Bowel Disease
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Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation
NCT01656603
Recruiting
This study will evaluate the safety of infusion of the investigational cord blood units by carefully documenting all infusion-related problems.
Gender:
ALL
Ages:
All
Trial Updated:
04/17/2024
Locations: National Institutes of Health, Bethesda, Maryland
Conditions: Infusion Reactions
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