Maryland is currently home to 2684 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Administration of Prothrombin Complex Concentrate vs. Standard Transfusion During/After Heart Transplantation
NCT03341156
Recruiting
This study is comparing the use of Kcentra vs. standard transfusion in patients undergoing heart transplantation surgery. Half of the patients will receive Kcentra, while the other half will receive fresh frozen plasma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/04/2024
Locations: University of Maryland, Baltimore, Maryland
Conditions: Heart Disease End Stage, Heart Failure，Congestive
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Pulmonary Hemodynamics During Exercise - Research Network
NCT03954574
Recruiting
The purpose of this Clinical Research Collaboration is to investigate the prognostic implications of pulmonary hemodynamics during exercise based on a large scale multi-centre approach by using retrospective and prospective analysis of hemodynamic data.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/02/2024
Locations: Johns Hopkins Hospital, Advanced HF, MCS, Transplant Cardiology, Baltimore, Maryland, USA, Baltimore, Maryland
Conditions: Pulmonary Circulation Diseases
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BlueWind RENOVA iStimâ„¢ System for the Treatment of OAB
NCT03596671
Recruiting
The OASIS study is prospective, interventional, multi-center study to evaluate the safety and efficacy of the BlueWind RENOVA iStimâ„¢ implantable tibial neuromodulation System for the treatment of patients diagnosed with overactive bladder.
Gender:
FEMALE
Ages:
Between 18 years and 80 years
Trial Updated:
12/29/2023
Locations: Chesapeake Urology - Hanover, Hanover, Maryland
Conditions: Treatment of Patients Suffering From Overactive Bladder (OAB)
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The Mobility Toolkit: Electronically Augmented Assessment of Functional Recovery Following Lower-extremity Trauma
NCT04047030
Recruiting
The study will prospectively enroll and follow 300 participants ages 18-60 surgically treated for a lower-extremity articular injury including fractures of the tibial plateau, pilon, ankle, and calcaneus.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
12/22/2023
Locations: University of Maryland R Adams Cowley Shock Trauma Center, Baltimore, Maryland
Conditions: Gait
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Multicenter Trial Evaluating the Safety and Efficacy of Autologous Volar Fibroblast Injection Into the Terminal Limb of Amputees.
NCT04839497
Recruiting
The study will enroll 20 adults ages 18-75 with a transtibial amputation with mature residual limbs who are ambulatory prosthesis users. Participants will be randomized to either treatment with low dose volar fibroblast injections (n=10) or to vehicle control (n=10). Participants will undergo a biopsy to harvest volar skin for fibroblast expansion and tattooing to identify injection sites on the residual limb. Fibroblasts will be processed at the Hopkins Cellular Therapy Core Lab and volar cells... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
12/21/2023
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Amputation
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A Study to Evaluate DAY101 in Pediatric and Young Adult Patients With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors
NCT04775485
Recruiting
FIREFLY-1 is an ongoing, Phase 2, multi center, open-label study to evaluate the safety and efficacy of oral pan-RAF inhibitor DAY101 in pediatric, adolescent, and young adult patients with recurrent or progressive low-grade glioma or an advanced solid tumor harboring a known RAF alteration.
Gender:
ALL
Ages:
Between 6 months and 25 years
Trial Updated:
12/21/2023
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Low-grade Glioma, Advanced Solid Tumor
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TPIV100 and Sargramostim for the Treatment of HER2 Positive, Stage II-III Breast Cancer in Patients With Residual Disease After Chemotherapy and Surgery
NCT04197687
Recruiting
This phase II trial studies how well TPIV100 and sargramostim work in treating patients with HER2 positive, stage II-III breast cancer that has residual disease after chemotherapy prior to surgery. It also studies why some HER2 positive breast cancer patients respond better to chemotherapy in combination with trastuzumab and pertuzumab. TPIV100 is a type of vaccine made from HER2 peptide that may help the body build an effective immune response to kill tumor cells that express HER2. Sargramostim... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/15/2023
Locations: University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Conditions: Breast Adenocarcinoma, Stage II Breast Cancer AJCC v6 and v7, Stage IIA Breast Cancer AJCC v6 and v7, Stage IIB Breast Cancer AJCC v6 and v7, Stage III Breast Cancer AJCC v7, Stage IIIA Breast Cancer AJCC v7, Stage IIIB Breast Cancer AJCC v7, Stage IIIC Breast Cancer AJCC v7
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The R-CITY Project: A Collaborative Intervention With Teachers and Youth
NCT05585918
Recruiting
"R-CITY" refers to the Collaborative Intervention with Teachers and Youth to practice and apply the 4 "Rs" of equity literacy skills in the classroom - Recognizing, Responding, Restoring Relationships, and Resilience. R-CITY is a collaborative teacher- and youth-focused prevention intervention that offers equity literacy lessons to accompany the Second Step social and emotional learning (SEL) curriculum. The lessons are designed to build teachers' and students' "equity stamina" and promote SEL s... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/14/2023
Locations: Shepard Pratt Health System, Towson, Maryland
Conditions: Violence
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Post-Concussion Musculoskeletal Injury Risks
NCT05122728
Recruiting
Musculoskeletal injuries (MSKI) and traumatic brain injury (TBI) are the signature injuries of the ongoing military conflicts. MSKI affect 800,000 Service Members annually and TBI have impacted more than 350,000 in the past 19 years and account for 22% of all combat casualties. Concussion, a mild form of TBI, increases MSKI risk in physically active individuals, including Service Members. The overall goal of the study is to identify the neuromuscular control mechanisms that increase MSKI risk f... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
12/11/2023
Locations: Walter Reed National Military Medical Center, Bethesda, Maryland
Conditions: Musculoskeletal Injury
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Cognitive and Vascular Functioning Following TBI
NCT06034509
Recruiting
This observational study will examine the association of chronic traumatic cerebrovascular injury and cardiovascular risk factors with TBI-related cognitive impairment and vascular dementia. Cerebrovascular, inflammatory, and neurodegenerative blood biomarkers as well as clinical and neuroimaging data
Gender:
ALL
Ages:
Between 18 years and 74 years
Trial Updated:
12/06/2023
Locations: Walter Reed National Military Medical Center, Bethesda, Maryland
Conditions: Traumatic Brain Injury, Cognitive Decline, Vascular Dementia
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Recovery and Outcomes From Stroke
NCT04007757
Recruiting
The investigators will perform follow-up on 500 cases of deep and lobar intracerebral hemorrhage to perform advanced neuroimaging before 45 days post stroke, and evaluations of motor and cognitive function at baseline, 3 months and 6 months to determine predictors of recovery, progressive cognitive or functional impairment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/06/2023
Locations: University of Maryland, Baltimore, Maryland
Conditions: Intracerebral Hemorrhage
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Neuroplasticity in Auditory Aging_Project 2 Aims 1 and 2
NCT03475043
Recruiting
Millions of elderly adults in the USA have age related hearing loss (ARHL), a malady that affects half of adults 60-69 years, and the majority of older adults. This hearing loss not only impacts communication and functional ability, but also is strongly associated with cognitive decline and decreased quality of life. This project aims to develop effective strategies to compensate and reverse this process through a deeper understanding of plasticity and adaptive auditory function, and how to enga... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
11/29/2023
Locations: University of Maryland, College Park, Maryland
Conditions: Auditory Perceptual Disorders, Aging Problems
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