Maryland is currently home to 2746 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Multicenter Trial Evaluating the Safety and Efficacy of Autologous Volar Fibroblast Injection Into the Terminal Limb of Amputees.
NCT04839497
Recruiting
The study will enroll 20 adults ages 18-75 with a transtibial amputation with mature residual limbs who are ambulatory prosthesis users. Participants will be randomized to either treatment with low dose volar fibroblast injections (n=10) or to vehicle control (n=10). Participants will undergo a biopsy to harvest volar skin for fibroblast expansion and tattooing to identify injection sites on the residual limb. Fibroblasts will be processed at the Hopkins Cellular Therapy Core Lab and volar cells... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
12/21/2023
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Amputation
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A Study to Evaluate DAY101 in Pediatric and Young Adult Patients With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors
NCT04775485
Recruiting
FIREFLY-1 is an ongoing, Phase 2, multi center, open-label study to evaluate the safety and efficacy of oral pan-RAF inhibitor DAY101 in pediatric, adolescent, and young adult patients with recurrent or progressive low-grade glioma or an advanced solid tumor harboring a known RAF alteration.
Gender:
All
Ages:
Between 6 months and 25 years
Trial Updated:
12/21/2023
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Low-grade Glioma, Advanced Solid Tumor
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A Study of CT-868 in Type 1 Diabetes Mellitus
NCT06062069
Recruiting
This study will evaluate the changes in glycemic control in overweight and obese adults with Type 1 Diabetes Mellitus after receiving CT-868 for 16 weeks. The effectiveness and safety of CT-868 will be compared to placebo. All participants will continue with their standard diabetes care using either an insulin pump (CSII) or multiple daily injections (MDI). Alongside their designated treatment, participants will receive guidance on managing their diabetes, including monitoring blood glucose leve... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/19/2023
Locations: Carmot Therapeutics Investigational Site 114, Hyattsville, Maryland
Conditions: Overweight, Obese, Type 1 Diabetes Mellitus
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TPIV100 and Sargramostim for the Treatment of HER2 Positive, Stage II-III Breast Cancer in Patients With Residual Disease After Chemotherapy and Surgery
NCT04197687
Recruiting
This phase II trial studies how well TPIV100 and sargramostim work in treating patients with HER2 positive, stage II-III breast cancer that has residual disease after chemotherapy prior to surgery. It also studies why some HER2 positive breast cancer patients respond better to chemotherapy in combination with trastuzumab and pertuzumab. TPIV100 is a type of vaccine made from HER2 peptide that may help the body build an effective immune response to kill tumor cells that express HER2. Sargramostim... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
12/15/2023
Locations: University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Conditions: Breast Adenocarcinoma, Stage II Breast Cancer AJCC v6 and v7, Stage IIA Breast Cancer AJCC v6 and v7, Stage IIB Breast Cancer AJCC v6 and v7, Stage III Breast Cancer AJCC v7, Stage IIIA Breast Cancer AJCC v7, Stage IIIB Breast Cancer AJCC v7, Stage IIIC Breast Cancer AJCC v7
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CT TAVR Abdomen Study
NCT05758701
Recruiting
A standard polyenergetic CT (computed tomography) procedure utilizes 100 ml of iodinated contrast. A recent world-wide shortage of iodine based intravenous contrast has highlighted the need to search for alternative methods or doses. Reducing iodinated IV contrast dose can mitigate IV contrast supply shortages and enable significant cost savings for the radiology practice and hospital system. In addition, decreased IV contrast dose can potentially reduce the rate of acute kidney injury, specific... Read More
Gender:
All
Ages:
Between 18 years and 88 years
Trial Updated:
12/14/2023
Locations: University of Maryland Medical Center, Baltimore, Maryland
Conditions: Transcatheter Aortic Valve Replacement
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The R-CITY Project: A Collaborative Intervention With Teachers and Youth
NCT05585918
Recruiting
"R-CITY" refers to the Collaborative Intervention with Teachers and Youth to practice and apply the 4 "Rs" of equity literacy skills in the classroom - Recognizing, Responding, Restoring Relationships, and Resilience. R-CITY is a collaborative teacher- and youth-focused prevention intervention that offers equity literacy lessons to accompany the Second Step social and emotional learning (SEL) curriculum. The lessons are designed to build teachers' and students' "equity stamina" and promote SEL s... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/14/2023
Locations: Shepard Pratt Health System, Towson, Maryland
Conditions: Violence
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RIC alloBMT With Post-transplant Cyclophosphamide for Refractory Systemic Sclerosis
NCT05298358
Recruiting
This is a Phase I, single arm, open label, single center pilot study to assess a reduced-intensity conditioning regimen, bone marrow transplantation with high dose cyclophosphamide (PTCy) in recipients with refractory systemic sclerosis. This study expects to enroll 15 donor/recipient pairs for a total of 30 participants. The primary objective of this study is to assess the safety of using a reduced intensity condition (RIC) preparative regimen bone marrow transplant (BMT) with post-transplant... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
12/11/2023
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Systemic Sclerosis
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Post-Concussion Musculoskeletal Injury Risks
NCT05122728
Recruiting
Musculoskeletal injuries (MSKI) and traumatic brain injury (TBI) are the signature injuries of the ongoing military conflicts. MSKI affect 800,000 Service Members annually and TBI have impacted more than 350,000 in the past 19 years and account for 22% of all combat casualties. Concussion, a mild form of TBI, increases MSKI risk in physically active individuals, including Service Members. The overall goal of the study is to identify the neuromuscular control mechanisms that increase MSKI risk f... Read More
Gender:
All
Ages:
Between 18 years and 40 years
Trial Updated:
12/11/2023
Locations: Walter Reed National Military Medical Center, Bethesda, Maryland
Conditions: Musculoskeletal Injury
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Cognitive and Vascular Functioning Following TBI
NCT06034509
Recruiting
This observational study will examine the association of chronic traumatic cerebrovascular injury and cardiovascular risk factors with TBI-related cognitive impairment and vascular dementia. Cerebrovascular, inflammatory, and neurodegenerative blood biomarkers as well as clinical and neuroimaging data
Gender:
All
Ages:
Between 18 years and 74 years
Trial Updated:
12/06/2023
Locations: Walter Reed National Military Medical Center, Bethesda, Maryland
Conditions: Traumatic Brain Injury, Cognitive Decline, Vascular Dementia
Register for Updates
Recovery and Outcomes From Stroke
NCT04007757
Recruiting
The investigators will perform follow-up on 500 cases of deep and lobar intracerebral hemorrhage to perform advanced neuroimaging before 45 days post stroke, and evaluations of motor and cognitive function at baseline, 3 months and 6 months to determine predictors of recovery, progressive cognitive or functional impairment.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/06/2023
Locations: University of Maryland, Baltimore, Maryland
Conditions: Intracerebral Hemorrhage
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AMI Construction in Lower Extremity Residual Limbs
NCT04063592
Recruiting
This study will involve the development of a novel approach to lower extremity residual limb surgical revision that offers the promise of augmenting volitional motor control, restore proprioception and reverse atrophy
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
12/05/2023
Locations: Walter Reed National Military Medical Center, Bethesda, Maryland
Conditions: Amputation
Register for Updates
IS-002 in Prostate Cancer
NCT05946603
Recruiting
Phase 2 randomized controlled multi-center study of IS-002, in conjunction with near-infrared (NIR) fluorescence imaging, for identification of prostate cancer during robotic-assisted radical prostatectomy (RARP) with (extended) pelvic lymph node dissection ((e)PLND) using the da Vinci® X/Xi Surgical System with Firefly® Fluorescence Imaging.
Gender:
Male
Ages:
Between 18 years and 75 years
Trial Updated:
12/01/2023
Locations: Johns Hopkins, Baltimore, Maryland
Conditions: Prostate Cancer
Register for Updates