Maryland is currently home to 2684 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
MACE CDS Software Master Enrollment Protocol
NCT06257628
Recruiting
This protocol will collect real world EHR data to support the product development life cycle activities associated with developing the Major Adverse Cardiac Events (MACE) Clinical Decision Support (CDS) software. The data will also be utilized in subsequent clinical validation to support an FDA application and/or applications to other regulatory agencies as needed.
Gender:
ALL
Ages:
23 years and above
Trial Updated:
02/05/2024
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Cardiac Events
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Safety, Tolerability and Pharmacokinetics of a Monoclonal Antibody Specific to B-and T-Lymphocyte Attenuator (BTLA) as Monotherapy and in Combination With an Anti-PD1 Monoclonal Antibody for Injection in Subjects With Advanced Malignancies
NCT04137900
Recruiting
The primary objective is to assess the safety and tolerability of TAB004 as monotherapy and in combination with toripalimab in subjects with selected advanced solid malignancies, including lymphoma, and to evaluate the recommended Phase 2 dose. The secondary objectives are to: 1) describe the pharmacokinetic (PK) profile of TAB004 monotherapy and in combination with toripalimab and to describe the PK profile of toripalimab when administered with TAB004, 2) evaluate antitumor activity of TAB004... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/01/2024
Locations: University of Maryland Medical Center, Baltimore, Maryland
Conditions: Advanced Unresectable Solid Tumor, Metastatic Solid Tumor
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STAT: Standard Therapy Plus Active Therapy
NCT04368117
Recruiting
The objective of the study is to assess the efficacy of STAT, an activity-based therapy protocol compared to standard therapy (ST) to improve functional outcome and reduce disability in patients recovering from burn injury. This randomized multi-center trial is designed with two parallel treatment groups: STAT and ST. Efficacy of the STAT protocol will be determined through comparison to the ST only group. It will be conducted at seven burn centers.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/31/2024
Locations: Johns Hopkins Bayview Medical Center, Baltimore, Maryland
Conditions: Burn Injury, Physical Injury, Thermal Burn
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The Effect of Sex Steroid Replacement Therapy in the Hypogonadism and Transgender Active-Duty Population
NCT06247267
Recruiting
It has been known that both estrogen and testosterone are the major sex steroids regulating bone metabolism and other physiological changes in both male and female, respectively. In postmenopausal women, osteoporosis is a major concern secondary to the lack of estrogen. These patients also experience a number of physiological changes that affect their life permanently to include hot flashes, irritability, difficulty concentrating, depression and mental confusion. In hypogonadal men, testosterone... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/30/2024
Locations: Walter Reed National Military Medical Center, Bethesda, Maryland
Conditions: Hypogonadism, Gender Identity Dysphoria
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A Study of AT-02 in Subjects With Systemic Amyloidosis.
NCT05951049
Recruiting
This is a Phase 2 open-label extension study to evaluate the long-term safety, tolerability, and clinical activity of AT-02. AT-02 is an investigational medicinal product being developed to treat systemic amyloidosis.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
01/29/2024
Locations: Johns Hopkins, Baltimore, Maryland
Conditions: Amyloidosis; Systemic
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Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials
NCT05338697
Recruiting
VERIFY will validate biomarkers of upper extremity (UE) motor outcome in the acute ischemic stroke window for immediate use in clinical trials, and explore these biomarkers in acute intracerebral hemorrhage. VERIFY will create the first multicenter, large-scale, prospective dataset of clinical, transmagnetic stimulation (TMS), and MRI measures in the acute stroke time window.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/24/2024
Locations: University of Maryland Medical Center, Baltimore, Maryland
Conditions: Stroke, Stroke, Acute, Stroke, Ischemic, Stroke Hemorrhagic
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A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 )
NCT04849728
Recruiting
This Phase 3 study is conducted to evaluate lanifibranor in adults with NASH and liver fibrosis histological stage F2 or F3
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/24/2024
Locations: Investigative Clinical Research - Annapolis, Annapolis, Maryland
Conditions: NASH - Nonalcoholic Steatohepatitis
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Wearable Spine Health System for Military Readiness
NCT05944354
Recruiting
The goal of this observational trial is to compare the health history and motion capabilities of participants with low back pain disorders to participants with healthy spines. The main question\[s\] it aims to answer are to: 1. Primary outcomes of this research effort include the development of composite measures or digital biomarkers to track functional recovery over time and predict duty or work status outcomes (return-to-full duty/work, limited duty/work restrictions or medical discharge/lon... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
01/22/2024
Locations: Uniformed Services University, Bethesda, Maryland
Conditions: Low Back Pain, Neck Pain
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Bicalutamide Implants (Biolen) With Radiation Therapy in Patients With Localized Prostate Cancer
NCT04943536
Recruiting
This study will be undertaken to evaluate the feasibility of replacing systemic Androgen Deprivation Therapy (ADT) with targeted local delivery of an anti-androgen agent alone in patients in whom ADT + radiation therapy is indicated for the treatment of localized prostate cancer.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
01/10/2024
Locations: National Cancer Institute, Bethesda, Maryland
Conditions: Prostate Adenocarcinoma
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C-Brace Prospective Registry
NCT04640584
Recruiting
To gather prospective safety and effectiveness data for the C-Brace System following the standard of care.
Gender:
ALL
Ages:
All
Trial Updated:
01/09/2024
Locations: Dankmeyer, Linthicum, Maryland
Conditions: Pareses, Lower Extremity
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Evaluating Effectiveness of Spices and Herbs to Increase Vegetable Intake Among Military
NCT05499858
Recruiting
"The goal of this study is to evaluate whether the addition of spices and herbs to the vegetables served to military personnel on a large military base can increase vegetable intake as compared to typical vegetable offerings without spices and herbs. A two-phase intervention will be conducted on base at Naval Station Activity Bethesda (NSAB) to evaluate whether the addition of spices and herbs to vegetable dishes can increase vegetable intake amongst military service members. Phase I will invo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/04/2024
Locations: Naval Support Activity Bethesda, Bethesda, Maryland
Conditions: Dietary Intake
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PRotein Optimization With eXercise to Improve MUscle Mass and Functional outcomeS
NCT05296096
Recruiting
The investigators have designed a 2-center, pilot feasibility, randomized controlled trial (PROXIMUS) to determine the feasibility and safety of a larger multi center, randomized open-label trial comparing high protein combined with individualized exercise vs. standard management during the acute phase of critical illness in children. The investigators aim to determine the impact of the intervention on preservation of muscle mass; and functional status at 1 month and 6 months after randomization... Read More
Gender:
ALL
Ages:
Between 1 year and 17 years
Trial Updated:
01/04/2024
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Muscle Loss, Protein, Mobility, Pediatric ALL
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