New York is currently home to 4504 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including New York, Rochester, Bronx and Buffalo. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
First in Human, Dose Escalation Study of AN4005
Recruiting
Open-label, multicenter, phase 1 study to investigate the safety, tolerability, and PK of AN4005 in patients with advanced tumors. This study is a first-in-human, dose escalation study with the objective to establish the MTD and/or RP2D of AN4005. Except for Dose Level 0 (50 mg), a traditional "3 + 3 design" will be utilized for dose finding with dose escalation and/or de-escalation as appropriate.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/22/2024
Locations: Montefiore Einstein Cancer Center, Bronx, New York
Conditions: Advanced Solid Tumor, Advanced Lymphoma
Fibulink Syndesmosis Repair System With Early Full-Weight Bearing
Recruiting
The purpose of the study is to evaluate the ability of the Fibulink Syndesmosis Repair System to maintain reduction of the ankle syndesmosis. Appropriate reduction of the syndesmosis is critical due the changes in tibiotalar contact pressure observed in cadaveric studies.6,7 Malreduction and instability of the distal tibiotalar joint can lead to chronic instability, increased articular damage and ultimately degenerative arthritis.7,8 Medial to lateral translation of distal tibia and fibula of 2... Read More
Gender:
ALL
Ages:
22 years and above
Trial Updated:
10/21/2024
Locations: Maimonides Medical Center, Brooklyn, New York
Conditions: Ankle Fractures, Bimalleolar Fractures, Syndesmotic Injuries, Bimalleolar Equivalent Fracture, Maisonneuve Fracture, Trimalleolar Fractures, Ankle Dislocation
Lenrispodun as Adjunctive Therapy in the Treatment of Patients With Motor Fluctuations Due to Parkinson's Disease
Recruiting
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, fixed-dose study in patients with a diagnosis of Parkinson's Disease consistent with the UK Parkinson's Disease Society (UKPDS) Brain Bank diagnostic criteria, who are experiencing wearing off symptoms and levodopa-induced dyskinesia.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
10/21/2024
Locations: Clinical Site, Albany, New York
Conditions: Parkinson Disease
A Study of AAV9 Gene Therapy in Participants With Canavan Disease (CANaspire Clinical Trial)
Recruiting
The main objective of this trial is to evaluate the safety, tolerability, and pharmacodynamic activity of BBP-812, an investigational AAV9-based gene therapy, in pediatric participants with Canavan disease.
Gender:
ALL
Ages:
30 months and below
Trial Updated:
10/21/2024
Locations: Weill Cornell Medicine; Division of Pediatric Neurology, New York, New York
Conditions: Canavan Disease
Prevention of Recurrent UTI Using Vaginal Testosterone Versus Placebo Placebo
Recruiting
Women over the age of 60 years have an estimated 10 to 15 % risk of recurrent urinary tract infections (UTI). This is believed to be due to hormonally induced changes in the vaginal flora associated with menopause. After menopause, there is a chemical changes in the vagina that may predispose to bacterial infections. The role of vaginal estrogen creams to restore vaginal atrophy and prevent urinary tract infections has been well characterized. Vaginal testosterone (VT) application use in postme... Read More
Gender:
FEMALE
Ages:
Between 60 years and 90 years
Trial Updated:
10/21/2024
Locations: Maimonides Medical Center, Brooklyn, New York
Conditions: Recurrent Urinary Tract Infection, Vaginal Atrophy, Postmenopausal Disorder
Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction
Recruiting
Heart failure with preserved ejection fraction (HFPEF) is common and deadly but without therapy. Inconclusive studies such as TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) suggest spironolactone may be effective in HFPEF, but it is generic and will not be studied by industry. SPIRRIT is a unique Registry-Randomized Clinical Trial (RRCT) that will test the hypothesis that spironolactone plus standard of care compared to standard of care alone reduc... Read More
Gender:
ALL
Ages:
Between 50 years and 99 years
Trial Updated:
10/21/2024
Locations: University at Buffalo, Buffalo, New York
Conditions: Heart Failure With Preserved Ejection Fraction
Anti-inflammatory Drugs and Serum Prostate-Specific Antigen Test
Recruiting
Prostate cancer is the most frequently diagnosed cancer in men in the Unites States. Nearly 1 million prostate biopsy procedures are performed in the United States annually and elevated prostate-specific antigen (PSA) level is the primary reason for prostate biopsy in \> 90% of cases. However, at the PSA levels which trigger prostate biopsy, often no cancer is found in prostate biopsy specimens. PSA test can be elevated due to reasons other than cancer such as inflammation or natural variation i... Read More
Gender:
MALE
Ages:
Between 18 years and 80 years
Trial Updated:
10/17/2024
Locations: Albany Medical Center, Albany, New York
Conditions: Prostate Cancer, Prostate Inflammation, PSA
Intravenous Gammaglobulin for Sickle Cell Pain Crises
Recruiting
The purpose of this study is to determine whether intravenous immune globulin is safe and effective in the acute treatment of pain crises in sickle cell disease. Funding Source: Food and Drug Administration (FDA), Office of Orphan Products Development (OOPD)
Gender:
ALL
Ages:
Between 6 years and 65 years
Trial Updated:
10/17/2024
Locations: Montefiore Medical Center, Bronx, New York
Conditions: Sickle Cell Disease, Pain
Intraventricular Catheter System for IVH
Recruiting
The purpose of this research study is to evaluate the safety and outcomes associated with the use of IRRAflow® System catheters in externally draining intracranial fluid to reduce intracranial pressure. This study will be comparing the IRRAflow® system to standard of care catheters used in the same procedure. The IRRAflow® system is FDA approved for this procedure.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/16/2024
Locations: Icahn School of Medicine at Mount Sinai, New York, New York
Conditions: Intraventricular Hemorrhage (IVH)
Vagal Nerve Stimulation in Enhanced Stroke Recovery: The VALOR Registry
Recruiting
Vagal Nerve Stimulation is a novel proven therapy for patients with chronic ischemic stroke. The primary objective of this registry is to assess the safety of vagal nerve stimulation for stroke recovery through monitoring the occurrence of serious adverse events associated with the surgical procedure or subsequent paired rehabilitation protocol. This registry will monitor patients undergoing VNS for stroke recovery in the Mount Sinai Health System and collect clinical and procedural details, obj... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/16/2024
Locations: Icahn School of Medicine at Mount Sinai, New York, New York
Conditions: Chronic Ischemic Stroke
A Post-Market Clinical Evaluation of the Treatment of Femur Fractures With the Femoral Nail GT
Recruiting
This investigation is a prospective, multi-center clinical investigation. It is anticipated that a total of 50 subjects will be enrolled. Neither subjects nor investigators are blinded to treatment and the clinical investigation includes a historical control which will be compared to the Femoral Nail GT of the T2 Alpha Femur Antegrade GT/PF Nailing System. Total duration of enrollment, 12 month follow-up and analysis is expected to take 25 months. The clinical investigation has been designed to... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/16/2024
Locations: New York University, New York, New York
Conditions: Femoral Fracture
Impact of a Standardized Obstetrics Note Template
Recruiting
The purpose of this study is to evaluate the effectiveness of a new standardized obstetrics note template on the quality, efficiency, and provider-perceived comprehensiveness of clinical documentation in a healthcare setting. The investigators aim to determine whether implementing standardized templates improves the completeness, clarity, and accuracy of clinical notes while reducing the time required for healthcare providers to review and document patient encounters.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/15/2024
Locations: Flushing Hospital Medical Center, Flushing, New York
Conditions: Obstetrics