Colorado is currently home to 1796 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Denver, Aurora, Colorado Springs and Englewood. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
5-Years PMCF Study of Ceramic Dental Implants One-piece Versus Two-piece.
NCT06287346
Recruiting
The goal of this cohort observational study is to compare in the survival rate of ceramic dental implants placed in patients with missing or hopeless teeth . The main question\[s\] it aims to answer are: * Are there any significant differences in survival rate between the use of one-piece ceramic implant versus the two-piece (TL) variant? * What are the complications associated to the procedure and differences between the two groups.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/29/2024
Locations: Family Holistic Dentistry, Boulder, Colorado
Conditions: Edentulism, Tooth Loss
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A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
NCT06008197
Recruiting
Finerenone will be compared to placebo to determine efficacy and safety of treatment in patients hospitalized with acute decompensated heart failure (HF) and mildly reduced or preserved left ventricular ejection fraction.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/29/2024
Locations: Aurora, CO Investigative Site, Aurora, Colorado
Conditions: Heart Failure, Acute Heart Failure
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Anti Inflammatory Lipid Mediators in Asthma Lipid Anti-Inflammtory Mediators in Asthma
NCT03762395
Recruiting
The main purpose of this Phase 2 double blind, placebo controlled crossover clinical study is to demonstrate the efficacy and safety of CXA-10 in obese adult asthmatics. Obesity induces a chronic systemic inflammatory state characterized by impaired adipokine signaling, pro-inflammatory cytokine responses, inflammatory cell activation and enhanced generation of oxidative inflammatory mediators. This impacts the lung, increasing the severity of asthma and its exacerbations. This research will eva... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/29/2024
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Asthma, Obesity
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A Prospective Study of a Mosaic Embryo Transfer
NCT04472156
Recruiting
This research is a prospective study in which the purpose is to investigate the clinical outcomes following the transfer of a mosaic embryo (presence of both chromosomally normal and abnormal cells) that has been screened for preimplantation genetic testing (PGT).
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
02/28/2024
Locations: Colorado Center for Reproductive Medicine, Lone Tree, Colorado
Conditions: Infertility
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DNA Analysis of Discarded Media Drops From the Clinical IVF Cycles
NCT03717441
Recruiting
Performing DNA analysis of discarded media drops from the clinical IVF cycles completed in our Center
Gender:
FEMALE
Ages:
Between 18 years and 44 years
Trial Updated:
02/28/2024
Locations: Colorado Center for Reproductive Medicine, Lone Tree, Colorado
Conditions: Infertility
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Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
NCT01574053
Recruiting
Enroll-HD is a longitudinal, observational, multinational study that integrates two former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North America and Australasia-while also expanding to include sites in Latin America. More than 30,000 participants have now enrolled into the study. With annual assessments and no end date, Enroll-HD has built a large and rich database of longitudinal clinical data and biospecimens that form the basis for studies developing tools and b... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/26/2024
Locations: Cenexel Rocky Mountain Clinical Research, LLC, Englewood, Colorado
Conditions: Huntington's Disease
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Development and Testing of a Pediatric Cervical Spine Injury Risk Assessment Tool
NCT05049330
Recruiting
Cervical spine injuries (CSI) are serious, but rare events in children. Spinal precautions (rigid cervical collar and immobilization on a longboard) in the prehospital setting may be beneficial for children with CSI, but are poorly studied. In contrast, spinal precautions for pediatric trauma patients without CSI are common and may be associated with harm. Spinal precautions result in well-documented adverse physical and physiological sequelae. Of substantial concern is that the mere presence of... Read More
Gender:
ALL
Ages:
18 years and below
Trial Updated:
02/21/2024
Locations: Children's Hospital Colorado, Denver, Colorado
Conditions: Cervical Spine Injury
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The Tether™ - Vertebral Body Tethering System Post Approval Study
NCT04505579
Recruiting
This study is an opportunity to provide continued reasonable assurance of the safety and probable benefit of The Tether HUD. The study will collect long term safety and efficacy information from patients who have had their idiopathic scoliosis treated via anterior vertebral body tethering (AVBT) with The Tether.
Gender:
ALL
Ages:
All
Trial Updated:
02/21/2024
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Scoliosis Idiopathic
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Cognitive Behavioral Intervention to Reduce Procedural Anxiety Among Woman With High Risk Pregnancies With Scheduled Cesarean Deliveries
NCT04203082
Recruiting
The goals of this study are to determine the feasibility and efficacy of a brief, single-session cognitive-behavioral intervention for reducing preoperative and postoperative anxiety and for determining satisfaction with the delivery process in pregnant women scheduled for Cesarean delivery due to complications with their pregnancy. This will be done through a combination of psychoeducation and exposure therapy, where the participants will be walked through the steps of a Cesarean delivery in an... Read More
Gender:
FEMALE
Ages:
Between 18 years and 60 years
Trial Updated:
02/20/2024
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Procedural Anxiety, High Risk Pregnancy, Fetal Complications
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SpermQT Prospective Observational Trial
NCT05966883
Recruiting
The goal of the study is to validate the ability of the Epigenetic Sperm Quality Test (SpermQT) to assess a man's sperm quality and corresponding success of infertility treatments.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
02/19/2024
Locations: Shady Grove Fertility, Greenwood Village, Colorado
Conditions: Male Infertility
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A Study to Investigate Leramistat in Patients With IPF
NCT05951296
Recruiting
To compare the effect of daily oral dosing of leramistat over 12 weeks with placebo in participants aged 40 years or older with idiopathic pulmonary fibrosis (IPF).
Gender:
ALL
Ages:
40 years and above
Trial Updated:
02/16/2024
Locations: National Jewish Health Main Campus, Denver, Colorado
Conditions: Idiopathic Pulmonary Fibrosis
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Micro and Macro Circulation in Sepsis
NCT05694455
Recruiting
Purpose: To assess the prognostic role of Handheld Vital Microscopy (HVM) and evaluate levels of endothelial glycocalyx (eGC) breakdown in patients demonstrating Hemodynamic Incoherence (HI), to elucidate a mechanistic link between the eGC and HI in order to inform prognostic enrichment of future resuscitation trials. We will serially evaluate microhemodynamics (MiH) and macro hemodynamics (maH) and the perfused boundary region (PBR, an visual proxy for eGC thickness) using HVM, and a validated... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
02/16/2024
Locations: Denver Health Medical Center, Denver, Colorado
Conditions: Sepsis, Septic Shock
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