Florida is currently home to 3785 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Miami, Tampa, Jacksonville and Orlando. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults (M3AX)
Recruiting
Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments that compromise healthspan and quality of life. Exercise is a multipotent treatment with promise to mitigate most aging hallmarks, but there is substantial variability in exercisÆ’e responsiveness. Combining endurance and resistance training in alignment with public health guidelines will be used to better understand variable exercise... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
05/13/2025
Locations: Florida Institute for Human and Machine Cognition, Pensacola, Florida
Conditions: Sarcopenia
REFLECT: Reproductive Education and Fertility Links for Cancer Treatment
Recruiting
The purpose of this study is to evaluate a web-based education tool geared at helping Adolescent and Young Adult (AYA) patients better understand fertility and genetic risks for cancer in future offspring.
Gender:
ALL
Ages:
Between 18 years and 39 years
Trial Updated:
05/13/2025
Locations: Moffitt Cancer Center, Tampa, Florida
Conditions: Reproductive Behavior
A Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors
Recruiting
This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1311/BNT324 in subjects with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2025
Locations: Research Site 118, Celebration, Florida
Conditions: Advanced Solid Tumors
A Study to Evaluate Impact of Efanesoctocog Alfa on Long-term Joint Health in Participants With Hemophilia A
Recruiting
This is a prospective, observational, multi-center longitudinal cohort study to describe the real-world effectiveness, safety and treatment usage of efanesoctocog alfa in patients with hemophilia A treated per standard of care in the US and Japan. Patients will be enrolled in the study after the introduction of efanesoctocog alfa in the hemophilia treatment landscape in each study country. Decision to initiate treatment with commercially available efanesoctocog alfa will be made by the treating... Read More
Gender:
ALL
Ages:
All
Trial Updated:
05/13/2025
Locations: William A. Shands Hospital at the University of Florida- Site Number : 8400032, Gainesville, Florida
Conditions: Hemophilia A
Study of Sipuleucel-T With or Without Continuing New Hormonal Agents in Metastatic Prostate Cancer
Recruiting
This study is designed to test the hypothesis that using Sipuleucel-T (Provenge) in combination with new hormonal agents (NHA) (abiraterone, enzalutamide, apalutamide) for the treatment of participants with asymptomatic metastatic castration resistant prostate cancer (mCRPC) and no visceral metastases would enhance the activation of antigen presenting cells (APC) by sipuleucel-T.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
05/13/2025
Locations: Moffitt Cancer Center, Tampa, Florida
Conditions: Prostate Cancer, Metastatic Prostate Cancer
Evaluation of Fractional Ablative Laser Treatment for Skin Conditions
Recruiting
Evaluate the safety and efficacy of the fractional ablative laser for treatment of skin laxity and tightening
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
05/13/2025
Locations: Sanctuary Plastic Surgery, Boca Raton, Florida
Conditions: Skin Laxity
IPH5201 and Durvalumab in Patients With Resectable Non-Small Cell Lung Cancer (MATISSE)
Recruiting
The study is intended to assess the safety and efficacy of neoadjuvant combination of IPH5201 and durvalumab in addition to standard chemotherapy and adjuvant combination of IPH5201 and durvalumab in untreated patients with resectable, early-stage (stage II to IIIA) non-small cell lung cancer (NSCLC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2025
Locations: St. Anthony's Hospital - BayCare Health System, Saint Petersburg, Florida
Conditions: Non Small Cell Lung Cancer
A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations
Recruiting
The objective of this Master Protocol is to evaluate the efficacy and safety of plixorafenib in participants with locally advanced or metastatic solid tumors, or recurrent or progressive primary central nervous system (CNS) tumors harboring BRAF fusions, or in participants with rare BRAF V600-mutated solid tumors, melanoma, thyroid, or recurrent primary CNS tumors.
Gender:
ALL
Ages:
10 years and above
Trial Updated:
05/13/2025
Locations: University of Miami Hospital and Clinics, Miami, Florida
Conditions: Cancer Harboring BRAF Alterations, HGG, LGG, Solid Tumors, Melanoma BRAF V600E/K Mutated, Thyroid Cancer
Technology Enabled Strategies to Promote Treatment Adherence in Liver Transplant
Recruiting
Liver transplantation is increasingly performed for older adults with multiple comorbidities. Medication adherence is key to maintaining proper function of the transplanted liver and optimize health; however, adhering to post-transplant treatment is complex. This trial will study how available technology combined with transplant center resources and caregiver support can optimize medication adherence, quality of life, and health outcomes among new liver transplant recipients at 3 centers.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2025
Locations: University of Miami, Miami, Florida
Conditions: Liver Transplant; Complications, Cirrhosis, End Stage Liver DIsease, Medication Adherence
A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome
Recruiting
This is a multicenter, Phase 3, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of clemizole HCL (EPX-100) as adjunctive therapy in children and adult participants with Dravet syndrome.
Gender:
ALL
Ages:
2 years and above
Trial Updated:
05/13/2025
Locations: Rare Disease Research FL, Kissimmee, Florida
Conditions: Dravet Syndrome
A Phase 1B/2 Study of RP1 in Solid Organ Transplant Patients With Advanced Cutaneous Malignancies
Recruiting
This Phase 1B/2 study is a multicenter, open-label, study of RP1 to investigate the (a) objective response rate, in addition to (b) safety and tolerability of RP1 for the treatment of advanced cutaneous malignancies in up to 65 evaluable organ transplant recipients. This will include patients with either previous renal, hepatic, heart, lung, or other solid organ transplantation or hematopoietic cell transplant and experiencing subsequent documented locally advanced or metastatic cutaneous malign... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2025
Locations: University of Miami Sylvester Comprehensive Cancer Center, Miami, Florida
Conditions: Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma, Basal Cell Carcinoma, Melanoma
Reducing Weight and Elevated Stress Levels Using Educational and Behavioral Tools
Recruiting
The purpose of this protocol is to test the effects on weight of an evidence-based behavioral weight loss program enhanced with culturally targeted stress management strategies compared to the evidence-based weight loss program alone among adult black females with obesity and elevated stress levels. Participants will be randomized to receive either a behavioral weight loss intervention with a focus on stress management or the weight loss intervention alone for 26 sessions.
Gender:
FEMALE
Ages:
Between 21 years and 75 years
Trial Updated:
05/13/2025
Locations: Moffitt Cancer Center, Tampa, Florida
Conditions: Obesity