Florida Clinical Trials

A listing of Florida clinical trials actively recruiting patient volunteers.

The main purpose of a clinical trial or research study is to test how effective and safe a new experimental treatment or intervention is in humans before it is released to the public. A clinical trial usually tests treatments such as medications, screening tests, alternative medicines such as herbs, and medical devices like prosthesis and pacemakers. There are a wide array of clinical research study centers in Florida that provide both paid and non-paid clinical trials.

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3863 trials found

Effect of Prolonged Nightly Fasting on Immunotherapy Outcomes in HNSCC - Role of Gut Microbiome

NCT05083416

This study aims to evaluate if eating within an 8-10-hour window during the day, without any caloric restriction, can lead to better response rates to immunotherapy in head and neck cancer patients.

Conditions: Head and Neck Cancer
Phase: Not Applicable

Study in Healthy Volunteers to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of CS0159

NCT05082779

The whole study includes 2 parts. Both the SAD study and MAD study are randomized, double-blinded, and placebo-controlled studies, conducted in healthy subjects, to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics profiles of CS0159. The SAD part also involves a pilot food effect (FE) study, designed to assess the food effect on single-dose PK profile in healthy subjects.

Conditions: Primary Sclerosing Cholangitis (PSC)

A Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus (CMV) Vaccine in Healthy Participants 16 to 40 Years of Age

NCT05085366

The main purpose of this study is to evaluate the efficacy of mRNA 1647 vaccine in CMV-seronegative female participants and to evaluate the safety and reactogenicity of mRNA-1647 vaccine in all participants.

Conditions: Cytomegalovirus Infection

FX-322 in Adults With Acquired Sensorineural Hearing Loss

NCT05086276

This is a Phase 2, prospective, randomized, double-blind, placebo-controlled, single-dose, multicenter study to evaluate the efficacy of FX-322, administered by intratympanic injection, in adults with acquired sensorineural hearing loss (SNHL).

Conditions: Hearing Loss, Sensorineural, Noise Induced Hearing Loss, Sudden Hearing Loss

Virtual and Video Counseling Versus In-Office Counseling for Laparoscopic Hysterectomy

NCT05086406

Compare preparedness for total laparoscopic hysterectomies between patients who undergo virtual visits and those who undergo in-office visits for pre-operative counseling.

Conditions: Patient Engagement
Phase: Not Applicable

A Study Evaluating the Safety, Pharmacokinetics, and Preliminary Efficacy of Orally Administered SM08502 Combined With Hormonal Therapy or Chemotherapy in Subjects With Advanced Solid Tumors

NCT05084859

This study is an open-label, multi-center, dose-escalation, dose expansion study in adult subjects with advanced solid tumors. The study will evaluate the safety, tolerability, PK, and preliminary anti-tumor efficacy of SM08502 administered orally (PO), once daily (QD), following a 5 days on 2 days off treatment schedule in combination with chemotherapy or hormonal therapy. Alternative dosing schedules may be explored in Part 1 if necessary. The recommended Part 2 dose and schedule for each comb ...

Conditions: Castration-resistant Prostate Cancer, Non-small Cell Lung Cancer, Colorectal Cancer

Chronic Pain Master Protocol (CPMP): A Study of LY3526318 in Participants With Chronic Low Back Pain

NCT05086289

The purpose of this study is to test whether LY3526318 is efficacious in relieving chronic low back pain (CLBP). This trial is part of the chronic pain master protocol (H0P-MC-CPMP) which is a protocol to accelerate the development of new treatments for chronic pain.

Conditions: Chronic Pain

A Study to Assess the Efficacy, Safety and Tolerability of IRL201104 in Adults With Active Eosinophilic Esophagitis

NCT05084963

The purpose of this study is to asses the efficacy, safety and tolerability of repeat doses of IRL201104 in Adult Participants with Active Eosinophilic Esophagitis (EoE)

Conditions: Eosinophilic Esophagitis

Neurolens Convergence Insufficiency Study

NCT05087563

To understand the benefits of the neurolens Measurement Device and neurolens treatment as it pertains to treating symptoms related to Convergence Insufficiency. It is a Prospective randomized double masked two arm performed on a minimum of 100 to a maximum of 150 subjects identified as symptomatic (CISS questionnaire score equal to or greater than 16) done across 3-10 clinical sites. There are two subgroups: a minimum of 50 in each subgroup(subgroup 1: pre-presbyopic (18-40 years); subgroup 2: p ...

Conditions: Binocular Vision Disorder, Convergence Insufficiency, Computer Vision Syndrome
Phase: Not Applicable

A Study of Safety and Immune Response to Different Doses of a Cytomegalovirus Vaccine in Healthy Adults

NCT05089630

The purpose of this study is to assess the safety, reactogenicity and immunogenicity of the candidate CMV recombinant protein subunit (CMVsu) vaccine consisting of a combination of glycoproteins B (gB) and pentamer antigens adjuvanted, regardless of baseline CMV sero-status. This FTiH study will be conducted in healthy adults 18 to 50 years of age, in which the 4 dose levels of the vaccine will be administered in a step-wise dose escalation manner, based upon safety adjudication.

Conditions: Cytomegalovirus Infections
Phase: Phase 1/2

A Study Comparing Two Formulations of Selpercatinib (LY3527723) in Healthy Participants

NCT05089019

The main purpose of this study is to compare the amount of selpercatinib that gets into the blood stream and how long it takes the body to get rid of it, when given as different formulations. The information about any adverse effects experienced will be collected and the tolerability of selpercatinib will also be evaluated. The study may last up to 56 days including the 28 days of screening period.

Conditions: Healthy

MagnetisMM-4: Umbrella Study of Elranatamab (PF-06863135) in Combination With Anti-Cancer Treatments in Multiple Myeloma

NCT05090566

The purpose of this study is to determine the Recommended Phase 2 Dose and clinical benefit of elranatamab in combination with other anti-cancer therapies in participants with multiple myeloma.

Conditions: Multiple Myeloma
Phase: Phase 1/2

Clinical trials have several phases, and each phase has a different goal. The first phases aim to measure the toxicity of a drug to learn what would be the correct dosage for a patient. During the first phases investigators also pay close attention to any side effects or potential dangers to consider before releasing the drug.

During the last few phases of clinical research studies, investigators test the intervention on larger and more inclusive groups of individuals to continue examining the effectiveness and side effects of the medication. If individual decides to enroll in a clinical trial the research team usually discloses what phase he/she is joining beforehand, however all phases usually have the same potential benefits and/or side effects.

In Florida, there are some large universities that conduct clinical trials and other types of research studies about different categories both for healthy and non-healthy volunteers. Universities often partner with local hospitals and doctors to conduct research studies. The University of Miami research division in Miami, Florida often partners with Jackson Health Systems. Together, they conduct the largest amount of clinical trials in South Florida with over 700 ongoing trials as of this month.

The University of Florida, located in Gainesville, Florida has conducted more than 4,000 research studies over the past four years and actively searches for both non-paid and paid volunteers to participate in clinical trials. You can also find clinical trials in local hospitals such as the Baptist Hospital, the Cleveland Clinic, and the Mayo Clinic. The following lists clinical trials located in Florida that have been provided by clinicaltrials.gov.

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