Florida is currently home to 3831 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Miami, Tampa, Jacksonville and Orlando. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis
Recruiting
This study (study ID PAC203 North America; PAC303 ex-North America) is evaluating 200 mg BID of pacritinib compared to physician's choice (P/C) therapy in patients with MF and severe thrombocytopenia (platelet count \<50,000/μL). Approximately 399 patients in total will be enrolled, randomized 2:1 to either pacritinib (approximately 266 patients) or to P/C therapy (approximately 133 patients) Condition or disease: Primary Myelofibrosis/Post-Polycythemia Vera Myelofibrosis/ Post-essential Thromb... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/26/2025
Locations: Cleveland Clinic Florida, Weston, Florida
Conditions: Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis
Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics And Pharmacodynamics of SIF001 in Healthy Subjects and in Epilepsy Patients
Recruiting
This is a dose escalation study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of SIF001, a monoclonal antibody with the potential to treat epilespy
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/25/2025
Locations: Accel Research sites network, DeLand, Florida
Conditions: Epilepsy, Healthy Volunteer
NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Recruiting
The study will evaluate the efficacy of NBI-1065845 compared with placebo as an adjunctive treatment in participants with MDD on improving symptoms of depression.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/25/2025
Locations: Neurocrine Clinical Site, Maitland, Florida
Conditions: Major Depressive Disorder
A Trial to Assess the Efficacy and Safety of TEV-53408 in Adults With Celiac Disease
Recruiting
The primary efficacy objective of the trial is to assess the ability of TEV-53408 to attenuate gluten-induced enteropathy in adults with celiac disease. The primary safety objective of the trial is to assess the safety of TEV-53408 in adults with celiac disease. A secondary objective is to further assess the efficacy of TEV-53408 in adults with celiac disease. The expected trial duration per participant is approximately 86 weeks.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
06/25/2025
Locations: Teva Investigational Site 12134, Inverness, Florida
Conditions: Celiac Disease
First-in-Human Study of ADCE-D01 in Soft Tissue Sarcoma
Recruiting
The goal of this clinical trial is to learn about the safety, tolerability and efficacy of ADCE-D01.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/25/2025
Locations: University of Miami - Sylvester Comprehensive Cancer Center, Miami, Florida
Conditions: Metastatic Soft Tissue Sarcoma, Unresectable Soft Tissue Sarcoma
Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy
Recruiting
The purpose of this study is to evaluate the efficacy, safety, and tolerability of Suzetrigine (SUZ) in participants with pain associated with diabetic peripheral neuropathy (DPN).
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
06/25/2025
Locations: AMR-Miami, Coral Gables, Florida
Conditions: Diabetic Peripheral Neuropathic Pain
Joining Under-connected Networks to Optimize "Salud" (Health) ("JUNTOS")
Recruiting
The objective of this study is to evaluate the JUNTOS Referral Network as an implementation strategy to enhance the reach of HIV-prevention and treatment services to Latino gay, bisexual, and other men who have sex with men (MSM).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/25/2025
Locations: University of Miami, Coral Gables, Florida
Conditions: Hiv
Meditation for Older Adults With Chronic Low Back Pain
Recruiting
This pilot randomized controlled trial aims to recruit 66 community-dwelling older adults with chronic low back pain and follow up them for 8 weeks. This study aims to test the preliminary effect of a mindfulness-based meditation (MBM) intervention on pain and symptoms among community-dwelling older adults with chronic low back pain, and also to test the effect of the MBM intervention on the host Gut-Brain Axis (GBA).
Gender:
ALL
Ages:
Between 50 years and 89 years
Trial Updated:
06/25/2025
Locations: Florida State University, Tallahassee, Florida
Conditions: Chronic Low Back Pain
Study of BB-031 in Acute Ischemic Stroke Patients (RAISE)
Recruiting
The purpose of this study is to evaluate the safety and tolerability of ascending doses (Part A) and selected doses (Part B) of BB-031 in acute ischemic stroke patients presenting within 24 hours of stroke onset. Participants will be randomized to receive one dose of either the investigational drug or placebo and will be followed for 90 days. A total of 156 patients are planned in this study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/25/2025
Locations: Baptist Health Medical Center, Jacksonville, Florida
Conditions: Acute Ischemic Stroke
PARADIGM - En Bloc Trial With the EndoQuest Endoluminal Surgical (ELS) System
Recruiting
The objective of this study is to evaluate the safety and effectiveness of the Endoluminal Surgical (ELS) System in subjects undergoing specified transanal endoluminal procedures in the rectum and sigmoid colon. Subjects will undergo endoscopic submucosal dissection (ESD), with or without closure at the discretion of the Investigator, of benign lesions in the rectum and sigmoid colon. The safety and effectiveness outcomes will be assessed intraoperatively and postoperatively at discharge and Da... Read More
Gender:
ALL
Ages:
Between 22 years and 80 years
Trial Updated:
06/25/2025
Locations: AdventHealth, Orlando, Florida
Conditions: Colorectal Lesion, Colorectal Adenoma, Colorectal Polyp, Rectal Lesion, Rectal Adenoma, Rectal Polyp, Sigmoid; Lesion, Sigmoid Colon Polyp
Study of Acalabrutinib and Rituximab in Untreated Elderly and/or Frail Patients With DLBCL
Recruiting
The study will measure the safety, tolerability, and efficacy with acalabrutinib in combination with rituximab in treatment-naïve elderly and/or frail patients with diffuse large B-cell lymphoma (DLBCL), who are otherwise unsuitable for standard front line chemoimmunotherapy treatments.
Gender:
ALL
Ages:
Between 65 years and 99 years
Trial Updated:
06/25/2025
Locations: Research Site, Jacksonville, Florida
Conditions: Diffuse Large B-Cell Lymphoma
Non-Inferiority Trial of TrIGR for PTSD
Recruiting
Trauma-related guilt is common and impairing among trauma survivors, particularly among Veterans with posttraumatic stress disorder (PTSD). The investigators' work shows that a brief treatment targeting trauma-related guilt, Trauma Informed Guilt Reduction Therapy (TrIGR), can reduce guilt and PTSD and depression symptoms. Whether TrIGR is no less effective than longer, more resource heavy PTSD treatments disseminated by by VA, like cognitive processing therapy (CPT), is the next critical questi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/25/2025
Locations: James A. Haley Veterans' Hospital, Tampa, FL, Tampa, Florida
Conditions: PTSD