Florida is currently home to 3770 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Miami, Tampa, Jacksonville and Orlando. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Pharmacokinetics and Safety of Epidiferphane and Taxanes in Breast Cancer Patients
Recruiting
Patients with breast cancer are commonly treated with taxane chemotherapy. Some very common side effects of taxanes, such as anemia and peripheral neuropathy, are often as not well addressed during treatment, resulting in dose reductions, dose delays and early discontinuation (collectively called relative dose intensity) of these chemotherapy agents in 15-80 % of patients on these drugs. This reduction in relative dose intensity (RDI) results in worse clinical outcomes such as progression free a... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
09/09/2024
Locations: University of Florida, Gainesville, Florida
Conditions: Breast Cancer
Estimation of Biomechanical Aortic Wall Properties in Healthy and Aneurysmal Aortas Using Novel Imaging Techniques
Recruiting
The primary aim of this study is to establish the practicality of using two novel imaging modalities for the assessment of biomechanical properties of the aorta.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/09/2024
Locations: Mayo Clinic Florida, Jacksonville, Florida
Conditions: Abdominal Aortic Aneurysm
Evaluating the Bacterial and Fungal Microbiome in Patients With Calcium Oxalate Urolithiasis and Renal Cell Carcinoma
Recruiting
The purpose of the study is to identify bacterial and fungal microbiome associated with calcium oxalate (CO) urolithiasis and renal cell carcinoma (RCC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/06/2024
Locations: University of Miami, Miami, Florida
Conditions: Calcium Oxalate Urolithiasis, Renal Cell Carcinoma
Serum Endotoxin Assay to Predict the Development of Postoperative Infectious Complications and Systemic Inflammatory Response Following Percutaneous Nephrolithotomy.
Recruiting
The aim of the study is to establish an infectious risk stratification system based on pre-and post-operative blood endotoxin profile.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/06/2024
Locations: University of Miami, Miami, Florida
Conditions: Nephrolithiasis, Urosepsis
Immune Reconstitution in Stem Cell Transplant Recipients
Recruiting
This specimen collection lab protocol will allow the investigators to prospectively study immune reconstitution in patients being treated for hematologic disorders and immune factors affecting graft versus host disease in stem-cell transplant (SCT) patients.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
09/06/2024
Locations: University of Miami, Miami, Florida
Conditions: Cancer
A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients with Autoimmune Disease
Recruiting
The most clinically meaningful way to discover new targets of T cells in autoimmune diseases is to study the tissues of patients with active autoimmune disease mediated organ inflammation. These tissues contain both cytotoxic and helper T cells that are driving their disease, and these T cells are being guided by TCRs that recognize tissue-specific targets. By collecting tissue when a patient has active inflammation, it is possible to determine which T cells are activated and undergoing clonal e... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/04/2024
Locations: Neurostudies, LLC, Port Charlotte, Florida
Conditions: Autoimmune Diseases, Ulcerative Colitis, Multiple Sclerosis, Scleroderma, Ankylosing Spondylitis, Celiac Disease, Non-radiographic Axial Spondyloarthritis (nr-axSpA), Crohn's Disease, Birdshot Chorioretinitis
Telephone-based Physical Activity Coaching or Self Monitored Physical Activity to Improve Physical Function in Older Adults Who Are Undergoing Surgery for Lung Cancer and Their Caregivers
Recruiting
This clinical trial compares telephone-based physical activity coaching to self monitored physical activity for improving physical function in older adults who are undergoing surgery for lung cancer and their caregivers. Lung cancer surgery in older adults is associated with functional declines and unique challenges. Performing physical activity around the time of surgery has been shown to improve functional outcomes in patients and exercise programs delivered via telehealth may improve access a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/04/2024
Locations: Moffitt Cancer Center, Tampa, Florida
Conditions: Lung Carcinoma
Single and Combined Effects of Behavioral, Academic, and Medication Treatments for ADHD in the Classroom
Recruiting
This study is the first to systematically evaluate the efficacy of single and combined academic accommodation, behavioral treatment, and medication treatment in a large sample of children with ADHD. Using a scientifically rigorous, cross-over design the impact of these approaches on ecologically valid measures of outcome (on-task behavior, quiz scores, academic productivity) will be assessed to inform effective school intervention.
Gender:
ALL
Ages:
Between 5 years and 12 years
Trial Updated:
09/04/2024
Locations: FIU Center for Childern and Families, Miami, Florida
Conditions: ADHD
Study of Inupadenant (EOS100850) with Chemotherapy As Second Line Treatment for Nonsquamous Non-small Cell Lung Cancer
Recruiting
The study will first determine the optimal dose of inupadenant to be given in combination with carboplatin and pemetrexed to patients that progressed after receiving first line anti-PD(L)1 treatment for locally advanced or metastatic non-small cell lung cancer. The efficacy and safety of the combination is then compared to standard of care carboplatin and pemetrexed in the same populations.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/04/2024
Locations: Mid-Florida Hematology & Oncology Centers, PA, Orange City, Florida
Conditions: Metastatic NSCLC - Non-Small Cell Lung Cancer, Locally Advanced NSCLC - Non-Small Cell Lung Cancer
Breast Cancer Locator Guided vs. Wire Localized Partial Mastectomy for Breast Cancer
Recruiting
This prospective, multicenter, 1:1 randomized, controlled trial is designed to evaluate the safety and effectiveness of the Breast Cancer Locator (BCL) in subjects with non-palpable invasive breast cancer or ductal carcinoma in situ (DCIS). Subjects will be randomized to breast conserving surgery (BCS) utilizing either the BCL or wire localization (WL) to guide surgery.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
09/04/2024
Locations: Baptist MD Anderson Cancer Center, Jacksonville, Florida
Conditions: Breast Cancer Female
IMMUNOPLANT for Newly Diagnosed Multiple Myeloma
Recruiting
The purpose of this study is to determine whether Linvoseltamab therapy in patients with newly diagnosed multiple myeloma will convert the disease status from minimal residual disease (MRD)-positive to MRD-negative, and increase the length of time that the disease is controlled. The researchers also want to find out the effects (good and bad) that Linvoseltamab has on participants and the condition.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/03/2024
Locations: University of Miami, Miami, Florida
Conditions: Multiple Myeloma
Discontinuation of Maintenance HER-2 Directed Therapy in Long-Term Survivors of Metastatic HER-2 Positive Breast Cancer
Recruiting
The purpose of this preliminary research study is to see if patients discontinuing maintenance Herceptin and/or other anti-HER-2 treatments with monitoring in addition to radiologic imaging and routine blood work will stay in complete radiological remission and to determine how long patients are able to stay in complete radiological remission without treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/03/2024
Locations: University of Miami, Miami, Florida
Conditions: HER2-positive Metastatic Breast Cancer, Stage IV Breast Cancer