Florida is currently home to 3835 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Miami, Tampa, Jacksonville and Orlando. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Neoplastic Barrett Esophagus: Endoscopic Piecemeal vs. En Bloc Resection
NCT03427346
Recruiting
The study will compare EMR versus ESD technique (both combined with subsequent ablative therapy) of mucosal resection in Barrett's esophagus with regard to efficacy and risk in a long term setting.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
06/27/2023
Locations: Orlando Health, Orlando, Florida
Conditions: Barrett Esophagus, Barrett Adenocarcinoma, Esophagus Neoplasm
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Electromagnetic Fields Versus Placebo For Child-Pugh A and B Patients With Advanced Hepatocellular Carcinoma
NCT04797884
Recruiting
The primary goals of this study are to compare overall survival and quality of life in subjects with Child-Pugh A or B advanced hepatocellular carcinoma when treated with a device emitting radiofrequencies modulated at specific frequencies or with a device emitting unmodulated radiofrequencies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/25/2023
Locations: Tampa General Hospital, Tampa General Cancer Center, Tampa, Florida
Conditions: Hepatocellular Carcinoma
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A Diagnostic Study of CD38-Targeted ImmunoPET of Myeloma
NCT04814615
Recruiting
Evaluation of myeloma disease burden is currently suboptimal. This limits treatment planning and evaluation of residual disease following treatment. 89Zr-DFO-daratumumab is a novel immunoPET tracer, designed to detect CD38 on myeloma cells and allow visualization of myeloma in a PET scanner. A phase I study of 89Zr-DFO-daratumumab demonstrated safety and successful visualization of myeloma with 89Zr-DFO-daratumumab. This will be a phase II study of 89Zr-DFO-daratumumab to evaluate potential clin... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
06/23/2023
Locations: University of Miami, Miami, Florida
Conditions: Multiple Myeloma
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Photobiomodulation for Myofascial Pelvic Pain
NCT05926752
Recruiting
The goal of this clinical trial is to evaluate the efficacy of photobiomodulation of the pelvic floor muscles in female Veterans with chronic pelvic pain. The main questions it aims to answer are: * Is there a difference in reduction in overall pelvic pain between women who undergo photobiomodulation compared to women who received pelvic floor physical therapy? * Is there a difference in compliance with therapy between the two groups? Participants will be randomized to treatment with either 9 t... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
06/21/2023
Locations: Orlando VA Medical Center, Orlando, Florida
Conditions: Pelvic Pain, Levator Ani Syndrome, Spastic Pelvic Floor Syndrome, Chronic Pelvic Pain Syndrome, Myalgia of Pelvic Floor
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LF111 or Drospirenone Chew vs Non-hormonal Contraceptive Methods on Bone Mineral Density in Adolescent and Adult Women
NCT05303636
Recruiting
The primary objective of this study is to evaluate the impact of LF111 and drospirenone (DRSP) 3.5 mg chewable tablets on bone mineral density (BMD) at the lumbar spine after 12 months (13 medication cycles) of investigation in comparison to non-hormonal contraceptive methods. Secondary objectives include further evaluating the impact of LF111 and DRSP 3.5 mg chewable tablets on BMD and bone turnover after 12 months (13 medication cycles) in comparison to non-hormonal contraceptive methods and a... Read More
Gender:
FEMALE
Ages:
Between 14 years and 45 years
Trial Updated:
06/15/2023
Locations: Advanced Clinical Research Network, Coral Gables, Florida
Conditions: Change in Bone Mineral Density, Bone Loss
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Natural History Study of and Genetic Modifiers in Spinocerebellar Ataxias
NCT01060371
Recruiting
Spinocerebellar ataxias (SCA) are genetic neurological diseases that cause imbalance, poor coordination, and speech difficulties. There are different kinds of SCA and this study will focus on types 1, 2,3, and 6 (SCA 1, SCA 2, SCA 3 , also known as Machado-Joseph disease and SCA 6). The diseases are rare, slowly progressive, cause increasingly severe neurological difficulties and are variable across and within genotypes. The purpose of this research study is to bring together a group of experts... Read More
Gender:
ALL
Ages:
6 years and above
Trial Updated:
05/30/2023
Locations: University of Florida, Gainesville, Florida
Conditions: Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2, Spinocerebellar Ataxia Type 3, Spinocerebellar Ataxia Type 6
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PTSD, AUD, and Interpersonal Conflict: Within-person Associations
NCT04552782
Recruiting
The present study seeks to increase understanding of Alcohol Use Disorder (AUD) and Posttraumatic Stress Disorder (PTSD) among veterans, an important public health concern. We will study the effects of regulatory deficits and sleep disturbance on the dynamic course of PTSD and AUD. The study will investigate whether a short, computerized training in the laboratory will alter maladaptive response biases and reduce associations between sleep disturbance, affect and behavioral dysregulation, AUD sy... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
05/08/2023
Locations: Bay Pines VA Health Care System, Bay Pines, Florida
Conditions: Stress Disorders, Post-Traumatic, Alcoholism
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Development and Assessment of a Spanish-Language Hearing Loss Toolkit for Self-Management
NCT04534387
Recruiting
The objective of this application is to develop and evaluate Spanish-language hearing education materials for adults. Our hypothesis is that participants will demonstrate better understanding of their hearing loss and associated difficulties, and will be better able to identify options for self-management following delivery of culturally and linguistically appropriate patient education materials.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
05/08/2023
Locations: University of South Florida, Tampa, Florida
Conditions: Hearing Loss
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Study 1: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients
NCT02133872
Recruiting
Hypertension (HTN) is the single most prevalent risk factor for cardiovascular disease, diabetes, obesity and metabolic syndrome. Recent American Heart Association (AHA) statistics indicate that one-third of all adults in the United States of America suffer from HTN. Despite advances in life style modification and multi-drug therapies, 20-30% of all hypertensive patients remain resistant. These individuals exhibit autonomic dysregulation due to elevated sympathetic activity and norepinephrine s... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
05/08/2023
Locations: UF Health Cardiovascular Clinic, Gainesville, Florida
Conditions: Hypertension
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PyloPlus Urea Breath Test System Post Therapy Efficacy Confirmation Study
NCT05681689
Recruiting
This is a multi-center, non-randomized, open label study. Subjects will be enrolled if they are deemed eligible given the inclusion criteria. Subjects who meet all inclusion criteria and none of the exclusion criteria will be entered into the study. Subjects will be exposed to non-radioactive 13C-Urea with citric acid, and may submit a stool sample or undergo endoscopy for Rapid Urease Test and Histology samples. Center(s) will house a PyloPlus UBT Analyzer to document results. PyloPlus Analyze... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/03/2023
Locations: Dolphin Medical Research, Doral, Florida
Conditions: Helicobacter Pylori Infection, Post-Treatment, Efficacy
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PyloPlus Urea Breath Test System Pediatric Safety and Efficacy Study
NCT05276557
Recruiting
This is a multi-center, non-randomized, open label study. Subjects will be enrolled on a walk-in basis. Screening data will be reviewed to determine subject eligibility. Subjects who meet all inclusion criteria and none of the exclusion criteria will be entered into the study. All children will be exposed to non-radioactive 13C-Urea with citric acid, and shall submit a stool sample. Centers will house a PyloPlus UBT Analyzer to document results. PyloPlus Analyzer results shall remain blinded to... Read More
Gender:
ALL
Ages:
Between 3 years and 17 years
Trial Updated:
05/03/2023
Locations: Dolphin Medical Research, Doral, Florida
Conditions: Helicobacter Pylori, Safety, Efficacy
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KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment
NCT03662126
Recruiting
This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with myelofibrosis (MF) who no longer benefit from treatment with a JAK inhibitor. Inhibition of MDM2 is a novel mechanism of action in MF. This study will be conducted in 2 phases. Phase 2 will determine the KRT-232 recommended dose and dosing schedule; Phase 3 will test KRT-232 vs Best Available Therapy (BAT). Patients in the Phase 3 part of the study will be randomized 2:1 to receive ei... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/26/2023
Locations: University Cancer Institute, Boynton Beach, Florida
Conditions: Primary Myelofibrosis (PMF), Post-Polycythemia Vera MF (Post-PV-MF), Post-Essential Thrombocythemia MF (Post-ET-MF)
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