Maryland is currently home to 2681 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Prospective Database of Infants With Cholestasis
NCT00061828
Recruiting
Biliary atresia, idiopathic neonatal hepatitis, and specific genetic cholestatic conditions are the most common causes of jaundice and hyperbilirubinemia that continue beyond the newborn period. The long term goal of the Childhood Liver Disease Research Network (ChiLDReN) is to establish a database of clinical information and plasma, serum, and tissue samples from cholestatic children to facilitate research and to perform clinical, epidemiological and therapeutic trials in these important pediat... Read More
Gender:
ALL
Ages:
6 months and below
Trial Updated:
06/04/2024
Locations: Johns Hopkins School of Medicine, Baltimore, Maryland
Conditions: Biliary Atresia, Neonatal Cholestasis
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Impact of Manual Therapy on Laryngeal Function Following Total Thyroidectomy
NCT06383091
Recruiting
In this clinical trial, the investigators are seeking to learn if a course of voice therapy, including neck massage, stretches and pain science education in addition to voice exercise and scar massage will effectively treatment patient complaints of swallowing or voice changes after total thyroidectomy as compared to voice exercise and scar massage alone. The main questions it aims to answer are: Will neck massage, stretches and pain science education reduce patient complaints of swallowing ch... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/03/2024
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Total Thyroidectomy
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Gleolan for Visualization of Newly Diagnosed or Recurrent Ovarian Cancer (OVA-302)
NCT05804370
Recruiting
This Phase 3 study is designed to investigate the safety, diagnostic performance, and clinical usefulness of Gleolan for the real-time detection and visualization of epithelial ovarian cancer tumors during debulking surgery. The study is planned to run for about 18 months with individual study participation lasting about two (2) weeks.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
06/03/2024
Locations: Luminis Health Anne Arundel Medical Center, Annapolis, Maryland
Conditions: Ovarian Cancer
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Combination Radiotherapy and Radiopharmaceutical Therapy Treatment Planning for Thyroid Cancer
NCT04892303
Recruiting
The goal of this study is to evaluate combined radioactive iodine (RAI, 131-I) and external beam radiotherapy (XRT) to optimize the radiation dose delivered to treat well differentiated thyroid cancers (DTC) with iodine-avid metastases. The investigators hypothesize that precise dosimetric planning will permit this combined RAI-XRT radiotherapeutic approach to be safe and permit higher tumor radiation doses than could otherwise be delivered. Patients with metastatic well-differentiated DTC) that... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
06/03/2024
Locations: The Johns Hopkins SKCCC, Baltimore, Maryland
Conditions: Recurrent Thyroid Cancer
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Tendon Transfer Rotator Cuff Tear
NCT04588506
Recruiting
This is a prospective randomized study on using muscle tendons to repair tears of the muscles on the shoulder. There are 3 muscles covering the shoulder joint- supraspinatus, infraspinatus and subscapularis. Large tears involving these muscles can be treated by using some muscle from another location of the body known as Tendon transfer techniques. These muscle tendons may be from the lower back (Latissimus Dorsi), upper pack (lower trapezius) or chest (pectoralis). There are currently no studie... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/03/2024
Locations: U of Maryland Baltimore, Baltimore, Maryland
Conditions: Rotator Cuff Tears
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Systemic Hypothermia in Acute Cervical Spinal Cord Injury
NCT02991690
Recruiting
This study is a prospective multi-center trial designed to determine the safety profile and efficacy of modest (33ºC) intravascular hypothermia following acute cervical (C1 to C8) Spinal Cord Injury (SCI).
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/03/2024
Locations: University of Maryland School of Medicine, Baltimore, Maryland
Conditions: Spinal Cord Injury, Acute
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Improving Psychological Outcomes for Acute Respiratory Failure Survivors Using a Self-Management Intervention
NCT06341972
Recruiting
A growing number of patients are surviving a stay in the intensive care unit (ICU) but may experience long-lasting psychological problems, but research evaluating such treatment for ICU patients is scant. The goal of this pilot randomized controlled trial is to evaluate the feasibility, acceptability, and potential benefit of an evidence-based psychological intervention for anxiety and associated outcomes for ICU patients. The main question\[s\] it aims to answer are: * Is this intervention f... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/01/2024
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Respiratory Failure, Anxiety, Critical Illness
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The Natural History of TRPV4 Neuropathy
NCT05600764
Recruiting
The goal of this research is to document the natural history of neuropathy in patients with a confirmed genetic mutation in the TRPV4 gene. The investigators are searching for patients willing to participate in a 6-year long study to document the symptoms of TRPV4-associated disease and their progression over time. Participation requires annual study visits at Johns Hopkins for adult and juvenile participants.
Gender:
ALL
Ages:
Between 3 years and 80 years
Trial Updated:
05/31/2024
Locations: Johns Hopkins, Baltimore, Maryland
Conditions: TRPV4 Gene Mutation
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Biomarker Validation in Motor System Physiology in Attention Deficit Hyperactivity Disorder
NCT04421248
Recruiting
Attention-Deficit/Hyperactivity Disorder (ADHD) is the most commonly diagnosed neurobehavioral disorder in childhood. Children with ADHD struggle in school due to problems with attention and high levels of impulsivity and hyperactivity. They are at substantially increased risk for long-term difficulties into adulthood, including academic underachievement, substance abuse, and criminal behavior. The diagnosis of ADHD, which is based on subjective ratings by parents and teachers, likely results fr... Read More
Gender:
ALL
Ages:
Between 8 years and 12 years
Trial Updated:
05/31/2024
Locations: Kennedy Krieger Institute, Baltimore, Maryland
Conditions: Attention Deficit Hyperactivity Disorder Combined
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1911GCCC: Galeterone or Galeterone With Gemcitabine for Patients With Metastatic Pancreatic Adenocarcinoma
NCT04098081
Recruiting
Assess the effectiveness of galeterone in advanced pancreatic adenocarcinoma
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/31/2024
Locations: University of Maryland Medical Center, Baltimore, Maryland
Conditions: Advanced Pancreatic Cancer
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A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Pallidotomy for the Treatment of Advanced, Idiopathic Parkinson's Disease With Medication-refractory Moderate to Severe Motor Complications
NCT05539196
Recruiting
This registry is a prospective, multicenter, international, single arm, observational post-approval registry with follow-up at 3, 6, and 12 months, and annually for 5 years. The proposed registry will enroll 60 subjects and will be conducted at approximately 10 centers worldwide.
Gender:
ALL
Ages:
Between 30 years and 99 years
Trial Updated:
05/30/2024
Locations: University of Maryland, Baltimore, Baltimore, Maryland
Conditions: Movement Disorders, Neurology, Parkinsons Disease
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Home-Based Exercise Tele-Rehabilitation After COVID-19
NCT05425264
Recruiting
The Coronavirus Disease 2019 (COVID-19) pandemic has resulted in catastrophic infections and fatalities across the nation. Many older Veterans with comorbidities are especially vulnerable to complications and poor recovery. This award will investigate the effect of a novel, home-based, supervised, group exercise tele-rehabilitation in Veterans recovered from COVID-19 on cardiopulmonary and physical function.
Gender:
ALL
Ages:
Between 50 years and 85 years
Trial Updated:
05/30/2024
Locations: Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD, Baltimore, Maryland
Conditions: Post SARS-CoV2 (COVID-19)
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