Maryland is currently home to 2746 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Transvaginal Low-level Laser Therapy to Improve Pelvic Pain and Sexual Function in Patients With Endometriosis.
Recruiting
Dyspareunia is defined as pain with penetrative sexual intercourse. Women with endometriosis have a nine-fold increased risk of dyspareunia, when compared to the general female population. A prospective single-blinded randomized controlled trial will be performed evaluating the change in pelvic pain and sexual satisfaction scores from baseline to 6 weeks after treatment with transvaginal photobiomodulation therapy or sham therapy. Treatment will involve 9 planned treatment sessions over 3-4 wee... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
09/01/2023
Locations: MedStar Mitchellville Clinic, Mitchellville, Maryland
Conditions: Endometriosis, Dyspareunia, Pelvic Pain
A Phase 3 Study to Investigate the Efficacy and Safety of SHR0302 With Moderately to Severely Active Ulcerative Colitis
Recruiting
This is a randomized, double-blind, placebo-controlled, multicenter Phase 3 study that will enroll approximately 368 subjects aged 18 to 75 years old with Moderately to Severely Active Ulcerative Colitis.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
09/01/2023
Locations: John Hopkins University, Columbia, Maryland
Conditions: Ulcerative Colitis
Assessing Ketorolac (Toradol) at Oocyte Retrieval
Recruiting
To determine if a nonsteroidal anti-inflammatory drug (NSAID), Ketorolac (Toradol), can improve pain control and decrease narcotic use after undergoing egg retrieval.
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
08/30/2023
Locations: Shady Grove Fertility Reproductive Science Center, Rockville, Maryland
Conditions: Infertility, Infertility, Female, Oocyte Retrieval, Postoperative Pain, Embryo Transfer
Tigulixostat, Phase 3 Study, Placebo Controlled in Gout Patients
Recruiting
The aim of this 6-month randomized multi-regional double-blind parallel group placebo-controlled phase 3 study is to assess the efficacy and safety of three different doses of Tigulixostat in gout patients with hyperuricemia.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
08/24/2023
Locations: MD Medical Research, Oxon Hill, Maryland
Conditions: Gout, Hyperuricemia, Gout Flare, Tophi
Study of TSR-042, an Anti-programmed Cell Death-1 Receptor (PD-1) Monoclonal Antibody, in Participants With Advanced Solid Tumors
Recruiting
This is a multi-center, open-label, first-in-human Phase 1 study evaluating the anti-programmed death receptor 1 (anti-PD-1) antibody dostarlimab (also known as TSR-042) n participants with advanced solid tumors who have limited available treatment options. The study will be conducted in 2 parts with Part 1 consisting of safety evaluation, pharmacokinetics (PK), and pharmacodynamics (PDy) of escalating doses of dostarlimab. Dose escalation will be based on ascending weight-based dose levels (DLs... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/18/2023
Locations: GSK Investigational Site, Baltimore, Maryland
Conditions: Neoplasms
Screening Protocol for Tumor Antigen Expression Profiling and HLA Typing for Eligibility Determination
Recruiting
This screening study is intended for men and women ≥ 18 to ≤ 75 years of age who have advanced solid or hematologic malignancy. The study will assess a subject's human leukocyte antigen (HLA) subtype and tumor antigen expression profile. Based on the results, it will be determined if a subject is eligible to be considered for Adaptimmune sponsored clinical trials testing the safety and efficacy of genetically changed T cells targeting specific tumor antigens. No treatment intervention will occur... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/18/2023
Locations: University of Maryland, Greenebaum Cancer Center, Baltimore, Maryland
Conditions: Solid and Hematological Malignancies
Recasting or Book Reading by Parents or Clinicians
Recruiting
Developmental Language Disorder (DLD) affects approximately seven percent of the population and is characterized by grammatical deficits that cascade into lifelong academic challenges and under-employment. Current treatments for DLD produce good outcomes under ideal, high intensity conditions or when parents have been trained to deliver therapy using intense coaching methods; however, current publicly funded service delivery systems and private-pay reimbursement models do not support treatment b... Read More
Gender:
All
Ages:
Between 4 years and 9 years
Trial Updated:
08/16/2023
Locations: University of Maryland, College Park, Maryland
Conditions: Developmental Language Disorder and Language Impairment
Optimal Post Tpa-Iv Monitoring in Ischemic Stroke
Recruiting
OPTIMISTmain is an investigator-initiated and conducted, international, multicentre, stepped wedge cluster randomized controlled trial comparing the effects of different intensities of nursing care monitoring for patients with acute ischemic stroke of mild severity and without critical care needs after IV-tPA.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/11/2023
Locations: University of Maryland Medical Center, Baltimore, Maryland
Conditions: Acute Ischemic Stroke Patients Receiving Reperfusion Therapy
Defense and Veterans Center for Integrative Pain Management (DVCIPM) Pain Registry Biobank
Recruiting
This Pain Registry Biobank is a prospective cohort design study whereby data (PASTOR survey, blood and saliva specimens, clinical data) is collected from participants in a longitudinal fashion with continual enrollment.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
08/10/2023
Locations: Walter Reed National Military Medical Center, Bethesda, Maryland
Conditions: Pain
A Phase 2 Clinical Study in Children With HeFH Aged 6 to 17 Treated Once Daily With Bempedoic Acid Oral Dosing
Recruiting
Multiple-dose study to measure PK, PD and safety of bempedoic acid in pediatric patients 6 to 17 years of age with HeFH.
Gender:
All
Ages:
Between 6 years and 17 years
Trial Updated:
08/08/2023
Locations: Continental Clinical Solutions, Towson, Maryland
Conditions: Hypercholesterolemia
Hyperthermia Treatment Added to Chemotherapy Standard of Care for Pancreatic Tumors
Recruiting
In this study, tumors of the pancreas are treated with a device placed around the abdomen that creates an electromagnetic field that generates heat in the tumor. Heating the tumor improves blood flow and the delivery of chemotherapy to the tumor as has been shown in numerous studies for various cancers with potential clinical benefits. Subjects will receive the thermal treatment on the same day and prior to receiving standard of care chemotherapy for a total of 4 treatments. This study is an ear... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/26/2023
Locations: University of Maryland, Baltimore, Maryland
Conditions: Pancreatic Cancer
Acute Effects of Autoregulated and Non-autoregulated Blood Flow Restrictive Bicep Curls
Recruiting
The purpose of this study is to investigate the acute effects of autoregulated (AR) and non-autoregulated (NAR) blood flow restriction (BFR) bicep curls on indices of arterial stiffness. We are attempting to differentiate physiological changes with AR and NAR bicep curl exercise. Twenty adults aged 18-40 years old will undergo three treatment sessions (control (no BFR), AR BFR and NAR BFR) in a randomized order separated by one week. A familiarization session will also occur one week before star... Read More
Gender:
All
Ages:
Between 18 years and 40 years
Trial Updated:
07/24/2023
Locations: Salisbury University, Salisbury, Maryland
Conditions: Arterial Stiffness, Healthy Lifestyle