New York is currently home to 4600 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including New York, Rochester, Bronx and Buffalo. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Tigulixostat, Phase 3 Study, Placebo Controlled in Gout Patients
Recruiting
The aim of this 6-month randomized multi-regional double-blind parallel group placebo-controlled phase 3 study is to assess the efficacy and safety of three different doses of Tigulixostat in gout patients with hyperuricemia.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
08/24/2023
Locations: Meridian Clinical Research, LLC, Vestal, New York
Conditions: Gout, Hyperuricemia, Gout Flare, Tophi
A Clinical Trial of BP1002 in Patients With Refractory/Relapsed Acute Myeloid Leukemia (AML)
Recruiting
This study evaluates the safety and tolerability of escalating doses of BP1002 (Liposomal Bcl-2 Antisense Oligodeoxynucleotide) in patients with refractory/relapsed AML. The study is designed to assess the safety profile, identify DLTs, biologically effective doses, PK, PD and potential anti-leukemic effects of BP1002 as single agent (dose escalation phase) followed by assessing BP1002 in combination with decitabine (dose expansion phase).
Gender:
All
Ages:
18 years and above
Trial Updated:
08/18/2023
Locations: Weill Cornell Medical College - NewYork-Presbyterian Hospital, New York, New York
Conditions: Acute Myeloid Leukemia, in Relapse, Acute Myeloid Leukemia Refractory
Study of TSR-042, an Anti-programmed Cell Death-1 Receptor (PD-1) Monoclonal Antibody, in Participants With Advanced Solid Tumors
Recruiting
This is a multi-center, open-label, first-in-human Phase 1 study evaluating the anti-programmed death receptor 1 (anti-PD-1) antibody dostarlimab (also known as TSR-042) n participants with advanced solid tumors who have limited available treatment options. The study will be conducted in 2 parts with Part 1 consisting of safety evaluation, pharmacokinetics (PK), and pharmacodynamics (PDy) of escalating doses of dostarlimab. Dose escalation will be based on ascending weight-based dose levels (DLs... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/18/2023
Locations: GSK Investigational Site, Albany, New York
Conditions: Neoplasms
Screening Protocol for Tumor Antigen Expression Profiling and HLA Typing for Eligibility Determination
Recruiting
This screening study is intended for men and women ≥ 18 to ≤ 75 years of age who have advanced solid or hematologic malignancy. The study will assess a subject's human leukocyte antigen (HLA) subtype and tumor antigen expression profile. Based on the results, it will be determined if a subject is eligible to be considered for Adaptimmune sponsored clinical trials testing the safety and efficacy of genetically changed T cells targeting specific tumor antigens. No treatment intervention will occur... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/18/2023
Locations: Roswell Park Cancer Institute, Buffalo, New York
Conditions: Solid and Hematological Malignancies
A Study to Evaluate the PK and PD of IM or SQ Injections of Levonorgestrel Butanoate (LB) for Female Contraception
Recruiting
This is a Phase I multicenter, open-label, dose-ranging, three-dose PK and PD study of injectable LB administered as an IM or SQ injection at 40 mg, and subsequently at 50mg SQ and then 60 mg SQ depending on the preliminary pharmacokinetic and pharmacodynamic results obtained with 40 mg dosing.
Gender:
Female
Ages:
Between 18 years and 40 years
Trial Updated:
08/11/2023
Locations: Columbia University, New York, New York
Conditions: Healthy Women, Female Contraception
Optimal Post Tpa-Iv Monitoring in Ischemic Stroke
Recruiting
OPTIMISTmain is an investigator-initiated and conducted, international, multicentre, stepped wedge cluster randomized controlled trial comparing the effects of different intensities of nursing care monitoring for patients with acute ischemic stroke of mild severity and without critical care needs after IV-tPA.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/11/2023
Locations: University of Rochester Medical Center, Rochester, New York
Conditions: Acute Ischemic Stroke Patients Receiving Reperfusion Therapy
The Effect of Guided Care With Vectra Compared to Treatment as Usual in Patients With Rheumatoid Arthritis
Recruiting
The goal of treating patients diagnosed with rheumatoid arthritis (RA) is to achieve remission or low disease activity and thereby prevent joint damage, loss of physical function, and disability. Optimal management requires regular assessment of disease activity, with treatment changes made as needed for optimal efficacy. Vectra is a blood serum test that looks at 12 biomarkers and produces a score on a scale of 1 to 100. The Vectra score has been shown to be the strongest predictor of risk for... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/07/2023
Locations: Rheumatology Associates of Long Island, Smithtown, New York
Conditions: Rheumatoid Arthritis (RA)
Validation of Optical Genome Mapping for the Identification of Constitutional Genomic Variants in a Postnatal Cohort
Recruiting
The purpose of this research use only (RUO) study is to detect genomic structural variants (SVs) in human DNA by Optical Genome Mapping (OGM) using the Bionano Genomics Saphyr system. SVs are a type of genetic alternation that includes deletions, duplications, and both balanced and unbalanced rearrangements (ex: inversions or translocations), as well as specific repeat expansions and contractions. The results of OGM analysis will be compared to prior clinical genetic test results to determine ho... Read More
Gender:
All
Ages:
All
Trial Updated:
08/04/2023
Locations: Columbia University Irving Medical Center, New York, New York
Conditions: Developmental Disability, Intellectual Disability, Autism Spectrum Disorder, Congenital Anomaly, Fragile X Syndrome, Facioscapulohumeral Muscular Dystrophy 1
Fluorescence Imaging of Carcinoma During Breast Conserving Surgery
Recruiting
Breast conserving surgery (BCS) is performed on patients with breast cancer to resect and completely remove the cancer while conserving as much of the surrounding healthy tissue as possible. Current methods do not allow surgeons to determine the completeness of surgical resection in real-time. This often results in the need for a second surgical procedure, or in some cases more than two surgical procedures in order to have confidence that all cancer has been removed. This Phase 3 study will eva... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
08/03/2023
Locations: Montefiore Medical Center, Bronx, New York
Conditions: Breast Neoplasm Female, Breast Cancer
A Study of Voruciclib Alone or in Combination With Venetoclax in Subjects With B-Cell Malignancies or AML
Recruiting
This is a Phase 1, open-label, dose escalation study to determine the safety and preliminary efficacy of voruciclib monotherapy in subjects with relapsed/refractory B cell malignancies or AML after failure of standard therapies or voruciclib in combination with venetoclax in subjects with relapsed or refractory AML
Gender:
All
Ages:
18 years and above
Trial Updated:
08/03/2023
Locations: New York University, New York, New York
Conditions: Follicular Lymphoma (FL), Mantle Cell Lymphoma (MCL), Marginal Zone Lymphoma (MZL), Small Lymphocytic Lymphoma (SLL), Chronic Lymphocytic Leukemia (CLL), Diffuse Large B-cell Lymphoma (DLBCL), Acute Myeloid Leukemia (AML)
Venetoclax and Lintuzumab-Ac225 in AML Patients
Recruiting
The study is a multicenter, open label Phase I/II trial. To determine the maximum tolerated dose (MTD) of lintuzumab-Ac225 added to venetoclax for patients with CD33 positive relapsed/refractory AML. (Phase 1 portion) To assess the percentage of patients with CR, CRh, or Overall Response (CR + CRh), up to 6 months after the start of treatment without receiving other AML therapies. (Phase 2 portion)
Gender:
All
Ages:
18 years and above
Trial Updated:
08/02/2023
Locations: Weill Cornell Medicine, New York, New York
Conditions: Acute Myeloid Leukemia, Relapsed Adult AML
CT for Personalized Mechanical Ventilation
Recruiting
The goal of this study is to compare two different ways of helping patients with a condition called sepsis who need help breathing using a machine called a ventilator. The investigators want to study which way of setting the ventilator is better for the lungs. Here are the main questions the investigators want to answer: How does the amount of air in the lungs and the way it moves differ between the two ways? How does the way air spreads out in different parts of the lungs differ between the t... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/28/2023
Locations: Columbia University, New York, New York
Conditions: Ventilator-Induced Lung Injury, Sepsis Syndrome, Mechanical Ventilation Complication