Texas is currently home to 4859 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Houston, Dallas, San Antonio and Austin. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
KRT-232 and TKI Study in Chronic Myeloid Leukemia
NCT04835584
Recruiting
This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with Ph+ Chronic Myeloid Leukemia (CML) who have relapsed or are refractory or intolerant to a Tyrosine Kinase Inhibitor (TKI). This study is a global, open label Phase 1b/2 to determine the efficacy and safety of KRT-232 in patients with chronic phase CML (CML-CP) and accelerated phase (CML-AP) who have failed TKI treatments.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2022
Locations: Texas Oncology- Sammons CC at Baylor, Dallas, Texas
Conditions: Chronic Myeloid Leukemia
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Brief Prolonged Exposure Therapy Versus Clinical Standard to Reduce Posttraumatic Stress Post Spinal Cord Injury
NCT05233111
Recruiting
This study will examine the use brief prolonged exposure (Brief PE) therapy compared to standard clinical care to reduce posttraumatic distress among people who have had a spinal cord injury and are receiving rehabilitation in an inpatient setting.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/15/2022
Locations: Baylor Institute for Rehabilitation, Dallas, Texas
Conditions: Spinal Cord Injuries, PTSD, Post-Traumatic Stress Disorder
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Pilot Study: KeraStat® Gel for Topical Delivery of Morphine for Management of Non-Healing, Painful Open Wounds and Ulcers
NCT05217160
Recruiting
This study is intended to provide information from subjects who currently have painful, chronically open wounds and assess the pain reduction capacity of KeraStat® Gel with Morphine. In gathering data from subjects who have baseline pain from their chronically open wounds, the investigators can then evaluate the capacity of KeraStat® Gel plus Morphine in reducing the subjects daily pain levels, pain associated with dressing changes, and pain medication consumption.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/19/2022
Locations: South Texas Aesthetic and Reconstructive Surgery, San Antonio, Texas
Conditions: Wound of Skin, Burns
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Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL
NCT05211856
Recruiting
The purpose of this study is to evaluate the efficacy and safety of acalabrutinib in combination with venetoclax and acalabrutinib in combination with venetoclax with and without obinutuzumab compared to chemoimmunotherapy in subjects with previously untreated CLL.
Gender:
All
Ages:
Between 18 years and 130 years
Trial Updated:
01/14/2022
Locations: Research Site, Fort Sam Houston, Texas
Conditions: Chronic Lymphocytic Leukemia
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ACute Uncomplicated Type b Aortic Dissection: Endovascular Repair vs. Best Medical Therapy
NCT02622542
Recruiting
The purpose of the study is to conduct a randomized controlled trial comparing best medical therapy (BMT) alone to BMT with thoracic endovascular aortic repair (BMT+TEVAR) for uncomplicated acute type B aortic dissection.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/11/2022
Locations: Department of Cardiothoracic and Vascular Surgery and Memorial Hermann Heart and Vascular Institute - Texas Medical Center, Houston, Texas
Conditions: Distal Aortic Dissection, Dissection, Aortic Acute, Acute Type B Aortic Dissection (Uncomplicated)
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Evaluating the Effect of Itraconazole on Pathologic Complete Response Rates in Esophageal Cancer
NCT04018872
Recruiting
Esophageal cancer, which has a low 5-year overall survival rate for all stages (\<20%) , is increasing in incidence. Previous studies have shown that the Hedgehog (Hh) and AKT signaling pathways are activated in a significant proportion of esophageal cancers. Itraconazole, a widely used anti-fungal medication, has been shown to inhibit various pathways involved in esophageal cancer tumorigenesis including Hh and AKT. In this phase II clinical trial, the investigators aim to evaluate the effect o... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/02/2021
Locations: Dallas VA Medical Center, Dallas, Texas
Conditions: Esophagus Adenocarcinoma, Esophagus Squamous Cell Carcinoma, Gastroesophageal Junction Adenocarcinoma
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Prospective Evaluation Of Outcomes For Patients Undergoing Radiofrequency Ablation (RFA) Using HALO Ultra Device For Gastric Antral Vascular Ectasia (GAVE)
NCT03525366
Recruiting
The purpose: To determine the safety and efficacy of Radiofrequency Ablation (RFA) HALO Ultra system in patients with Gastric Antral Vascular Ectasia patient cohort (GAVE). Research design: This is a prospective observational study. Procedure Used: Radiofrequency Ablation Risks and potential benefits: There are no risks associated with this study as it is a retrospective chart review. Potential benefits include the knowledge gained from this study which may be of help to patients in the futur... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
09/30/2021
Locations: Memorial Hermann Hospital, Houston, Texas
Conditions: Gastric Antral Vascular Ectasia
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iGlucose® Remote Patient Monitoring Device as an Adjunct to Routine Glucose Meter Devices for Glycemic Management and Control in Gestational Diabetes
NCT04206748
Recruiting
The purpose of this study is to investigate whether automation of glucose monitoring data to facilitate the total number of recommended and completed SMBG checks improve clinical outcomes for women living with gestational and type 2 diabetes during pregnancy? This is a RCT
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
09/01/2021
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Gestational Diabetes, Type2 Diabetes, Pregnancy in Diabetic
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Breast Mesh Used in Two-staged Breast Reconstruction
NCT04967976
Recruiting
This is the first prospective randomized and controlled study on the efficacy and safety of TiLOOP® Bra mesh in patients with expander-implant breast reconstruction. The investigators hypothesize that incoporating TiLOOP Bra mesh with tissue expanders will reduce the rates of capsular contraction, improve the efficiency of expansion and provide better aesthetic result.
Gender:
FEMALE
Ages:
Between 18 years and 70 years
Trial Updated:
07/19/2021
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Breast Cancer, Radiation, Breast Reconstruction, Synthetic Mesh
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Sternal Block With Liposomal Bupivacaine vs. Saline Prior to Incision in Cardiac Surgery
NCT04333095
Recruiting
The purpose of this study is to find out what effects (good and bad) that the study medicine called "liposomal bupivacaine" has on subjects that are undergoing a sternotomy. Liposomal bupivacaine solution, is a drug that the doctor will inject before they make the cut through patient's breastbone (sternotomy). Normally pain medicine like this is given right before the surgeon closes up the patient's breastbone, at the end of the surgery. For this study, they want to see if giving the medicine be... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/08/2021
Locations: Baylor Scott & White Heart Hospital - Plano, Plano, Texas
Conditions: Cardiovascular Surgery, Pain, Postoperative, Block
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Registry and Biorepository for IBD in Central Texas
NCT04617184
Recruiting
This is a prospective, non-interventional registry and biorepository for patients with IBD. Longitudinal follow-up data is collected from both patients and their treating gastroenterologist during routine clinical encounters. The biorepository will consist of prospective collection of blood samples, tissue samples, and fecal samples for research purposes, while the participants are undergoing a clinically-indicated procedure (i.e. venipuncture for routine tests, IV catheter placement, and/or end... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
05/13/2021
Locations: Dell Medical School, UT Austin, Austin, Texas
Conditions: Crohn Disease, Ulcerative Colitis, Inflammatory Bowel Diseases
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Designing a Predictive Tool to Identify Whether a Cancer Patient Has Bacteremia Due to Ceftriaxone-Resistant Escherichia Coli
NCT04866186
Recruiting
This study aims to develop a tool to predict whether a cancer patient has bacteria in the blood (bacteremia) due to ceftriaxone-resistant Escherichia (E.) coli. This study may help researchers identify risk factors for ceftriaxone-resistant E. coli bacteremia in cancer patients and improve antibiotic treatment in these patients.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/28/2021
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Escherichia Coli Infection, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
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