Florida is currently home to 3831 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Miami, Tampa, Jacksonville and Orlando. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Janus Kinase (JAK) Inhibitors to Preserve C-Peptide Production in New Onset Type 1 Diabetes (T1D)
Recruiting
A multi-center, placebo-controlled, double blind, 1:1:1 randomized control clinical trial testing two different JAK Inhibitors abrocitnib, ritlecitinib, and placebo in subjects with recent onset Stage 3 Type 1 Diabetes within 100 days of diagnosis.
Gender:
ALL
Ages:
Between 12 years and 35 years
Trial Updated:
06/09/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Diabetes Mellitus, Type 1
Intervention to Prevent Behavioral Health Symptoms Among Pandemic Affected Children
Recruiting
Racial and ethnic minority children who live in socioeconomically disadvantaged communities are disproportionately impacted by pandemic and climate-induced disasters. Although effective interventions have been designed to treat mental health related symptoms in post-disaster settings, accessible, empirically supported prevention interventions are needed to prevent the onset of mental and behavioral health issues among these children. Building on our preliminary findings, the proposed study exami... Read More
Gender:
ALL
Ages:
Between 8 years and 14 years
Trial Updated:
06/09/2025
Locations: Boys and Girls Club of Manatee County, Bradenton, Florida
Conditions: Emotional Distress, Prosocial Behavior, Pandemic, COVID-19, Coping Skills, Social Support
Use Muscadine Wine Nutraceuticals to Improve Brain Health, Cognition, and Mental Health
Recruiting
Previous studies have shown that polyphenol-rich foods can positively affect cognitive functions, memory, and mood in humans. We hypothesize that both acute and chronic intake of muscadine wine polyphenols will improve cognitive performance and mood through regulating the HPA axis, alleviating inflammation and oxidative stress, and/or inhibiting monoamine oxidase activities
Gender:
ALL
Ages:
Between 50 years and 65 years
Trial Updated:
06/09/2025
Locations: Food Science and human nutrition department at University of Florida, Gainesville, Florida
Conditions: Cognitive Performance, Memory, Mood, Anxiety
Microbiome Dysfunction in Surgical Intensive Care Unit Survivors
Recruiting
Oral and gastrointestinal microbiome dysfunction has been demonstrated to be a culprit of various systemic dysfunctions in peripheries such as cardiovascular, nervous, endocrine and musculoskeletal systems. The topic of microbiome dysfunction after surgical intensive care admission is understudied but may be responsible for persistent systemic inflammation clinically observed in surgical intensive care patients. Therefore, the objective of this project is to investigate the oral and gut microbio... Read More
Gender:
ALL
Ages:
Between 18 years and 110 years
Trial Updated:
06/09/2025
Locations: UF Health at Shands Hospital, Gainesville, Florida
Conditions: Sepsis, Trauma Injury
Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer
Recruiting
The overarching objective of this project is to develop a pan-gynecologic cancer detection test using gynecologic (unique endometrial, cervical, and ovarian cancer) cancer-specific methylated DNA markers and high-risk human papilloma virus (HR-HPV) detected in vaginal fluid and/or plasma. This proposal defines Phase II MDM-based cancer detection studies in endometrial cancer (EC) and endometrial hyperplasia with atypia (AEH) in vaginal fluid and 2) ovarian cancer (OC) in plasma and vaginal flui... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
06/09/2025
Locations: Mayo Clinic, Jacksonville, Florida
Conditions: Endometrial Cancer, Cervical Cancer, Atypical Endometrial Hyperplasia, Cervical Dysplasia, Adnexal Mass, Ovarian Cancer
Preoperative Radiosurgery for the Treatment of High Grade Glioma, NeoGlioma Trial
Recruiting
This phase I trial finds out the possible benefits and/or side effects of radiosurgery before surgery (preoperative) in treating patients with high grade glioma. Radiosurgery uses special equipment to position the patient and precisely give a single large dose of radiation to the tumor. This method may kill tumor cells with fewer doses over a shorter period and cause less damage to normal tissue. Giving pre-operative radiosurgery may improve the odds of brain tumor control and reduce treatment-r... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/09/2025
Locations: Mayo Clinic in Florida, Jacksonville, Florida
Conditions: Malignant Glioma
Effects of 100% Orange Juice on Skin Health in Women
Recruiting
Daily consumption of Orange Juice (OJ) protects skin against UV-induced damages and wrinkling, improves skin barrier function and overall skin health by decreasing oxidative stress, inflammation, and protein glycation. The positive effects of OJ on skin appearance are associated with improvements of the stratum corneum lipidomic and skin microbiome.
Gender:
FEMALE
Ages:
Between 45 years and 65 years
Trial Updated:
06/09/2025
Locations: Food Science and Human Nutrition Department at University of Florida, Gainesville, Florida
Conditions: Skin Health
A Randomized Trial to Evaluate Sequential vs Simultaneous Patching
Recruiting
A randomized trial to determine whether simultaneous treatment with spectacles and patching has an equivalent VA outcome compared with sequential treatment, first with spectacles alone followed by patching (if needed), for previously untreated amblyopia in children 3 to \<13 years of age.
Gender:
ALL
Ages:
Between 3 years and 13 years
Trial Updated:
06/09/2025
Locations: Nova Southeastern University College of Optometry, The Eye Institute, Fort Lauderdale, Florida
Conditions: Amblyopia
Vasculitis Pregnancy Registry
Recruiting
The purpose of this study is to learn about the experience of women with vasculitis who become pregnant. In particular, the study will consist of several online surveys to assess 1. each woman's vasculitis severity and pregnancy-related experiences, and 2. pregnancy outcomes.
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
06/09/2025
Locations: University of South Florida Data Management and Coordinating Center, Tampa, Florida
Conditions: Vasculitis, Behcet's Disease, CNS Vasculitis, Cryoglobulinemic Vasculitis, Eosinophilic Granulomatosis With Polyangiitis (EGPA), Churg-Strauss Syndrome (CSS), Granulomatosis With Polyangiitis (GPA), Wegener's Granulomatosis, IgA Vasculitis, Henoch-Schoenlein Purpura (HSP), Microscopic Polyangiitis (MPA), Polyarteritis Nodosa (PAN), Takayasu Arteritis (TAK), Urticarial Vasculitis, Systemic Vasculitis
A Trial to Assess Gastrointestinal Responses to Dietary Fibers in Adults Using Weight Loss Medications
Recruiting
The objective of this study is to assess self-reported gastrointestinal (GI) responses to three snack bars containing fiber/fiber blends vs. a control snack bar for 7 days each in adults using GLP-1 agonists.
Gender:
ALL
Ages:
Between 25 years and 64 years
Trial Updated:
06/06/2025
Locations: Excellence Medical and Research, Miami Gardens, Florida
Conditions: Gastrointestinal Symptoms, Weight Loss, GLP-1
A Study to Compare TAK-881 and HYQVIA in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
Recruiting
The main aim of this study is to evaluate the pharmacokinetic (PK) comparability between TAK-881 and HYQVIA subcutaneous (SC) administration for maintenance therapy of CIDP. The participants who are already receiving intravenous immunoglobulin G (IGIV), conventional subcutaneous intravenous immunoglobulin G (cIGSC), or HYQVIA will be treated with the same dose equivalent as their prior IG treatment with HYQVIA for 24 weeks followed by TAK-881 for 24 weeks. Participants will need to visit the c... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/06/2025
Locations: Knight Neurology, Rockledge, Florida
Conditions: Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer and Tabirafusp Tedromer Compared to Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD) - DAYBREAK
Recruiting
A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer and Tabirafusp Tedromer Compared to Aflibercept in Participants with Neovascular (Wet) Age-related Macular Degeneration (wAMD)
Gender:
ALL
Ages:
50 years and above
Trial Updated:
06/06/2025
Locations: Blue Ocean Clinical Research, Clearwater, Florida
Conditions: Wet Age-related Macular Degeneration