Florida is currently home to 3815 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Miami, Tampa, Jacksonville and Orlando. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Phase 1 Study of RBN-2397, an Oral PARP7 Inhibitor, in Patients With Solid Tumors
NCT04053673
Recruiting
RBN-2397 inhibits PARP7, an enzyme that is switched on by cancer stresses, such as the toxins in cigarette smoke. Cancer cells use PARP7 to hide from the immune system by stopping the cell from sending a signal (Type 1 interferon) that tells the immune system that something is wrong and to kill the cell. RBN-2397 has been shown in animal studies to inhibit tumor growth and also shuts down the "don't kill me" signal the tumor is sending to evade the immune system. As a PARP7 inhibitor RBN-2397 is... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/27/2023
Locations: Sarah Cannon Research Institute at Florida Cancer Specialists, Orlando, Florida
Conditions: Solid Tumor, Adult
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Immuno-bridging and Broadening Study of a Whole, Inactivated COVID-19 Vaccine BBV152 in Healthy Adults
NCT05258669
Recruiting
A randomized, observer-blind, placebo-controlled immuno-bridging, and broadening study to demonstrate the equivalence of the immune response between participants enrolled in Phase 3 efficacy trial in India and demographically diverse healthy adult participants in the US which matched in age and vaccine formulation setting to whom those efficacy results are extrapolated; and to assess the broadening of the BBV152 in participants who previously received two shots of messenger ribonucleic acid (mRN... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/24/2023
Locations: Palm Springs Community Health Center, Miami Lakes, Florida
Conditions: COVID-19
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Airway Clearance for Pediatric and Adult Cystic Fibrosis Patients Using a Portable Intra-Pulmonary Percussion Device
NCT04743206
Recruiting
This is a pilot study where the investigators aim to compare initial use of the standard airway clearance device (SACD) with subsequent use of a Portable Intra-Pulmonary Percussion Device (PIAPD) in patients with cystic fibrosis ages 6 -21 years. The primary hypothesis is that there is no effect of PIAPD on FEV1 2 hours after use, there is no effect on perception of effort and efficacy for the PIAPD. If both are equally effective, the latter device provides an alternative that is both cheaper an... Read More
Gender:
All
Ages:
Between 6 years and 21 years
Trial Updated:
03/23/2023
Locations: UF Medical Plaza Pulmonary Clinic, Gainesville, Florida
Conditions: Cystic Fibrosis
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Study of ANX005 in Adults With Amyotrophic Lateral Sclerosis (ALS)
NCT04569435
Recruiting
This study is a multi-center, open-label study of intravenous (IV) ANX005 in participants with ALS.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/23/2023
Locations: Annexon Investigational Site 02, Gainesville, Florida
Conditions: Amyotrophic Lateral Sclerosis
Register for Updates
Atypical Hemolytic-Uremic Syndrome (aHUS) Registry
NCT01522183
Recruiting
Post-marketing safety data on patients treated and untreated with eculizumab or ravulizumab.
Gender:
All
Ages:
All
Trial Updated:
03/23/2023
Locations: Clinical Trial Site, Gainesville, Florida
Conditions: Atypical Hemolytic-Uremic Syndrome
Register for Updates
Standard Process Heart and Gut Health Study
NCT05795946
Recruiting
Standard Process Heart and Gut Health Study
Gender:
All
Ages:
Between 25 years and 80 years
Trial Updated:
03/21/2023
Locations: Docs Outside the Box, Saint Petersburg, Florida
Conditions: Nutrition, Healthy
Register for Updates
Using a mHealth Intervention to Promote Physical Activity in Phase III Cardiac Rehabilitation Clients
NCT05795036
Recruiting
In this study, we will implement a pilot project of using activity tracker (i.e., Fitbit) with phase III CR clients. The study will record the clients' daily steps and sleep patterns for 8 consecutive weeks in natural settings. Two specific aims are identified for this project: Develop an intervention protocol using mHealth to promote Phase III CR clients' self-monitoring of PA. Examine the efficacy of the intervention on clients' PA, sleep patterns, functional capacity and QoL.
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
03/21/2023
Locations: AdventHealth University, Orlando, Florida
Conditions: Cardiac Rehabilitation, Physical Activity
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Gut Microbiome Dysfunction in Sepsis and Trauma Survivors
NCT05357170
Recruiting
Gastrointestinal microbiome dysfunction has been demonstrated to be a culprit of various systemic dysfunctions in peripheries such as cardiovascular, nervous, endocrine and musculoskeletal systems. The topic of microbiome dysfunction after sepsis and trauma injury is understudied but may be responsible for persistent systemic inflammation clinically observed in sepsis and trauma survivors. Therefore, the objective of this project is to investigate the gut microbiome after acute phase of sepsis o... Read More
Gender:
All
Ages:
Between 18 years and 110 years
Trial Updated:
03/21/2023
Locations: UF Health at Shands Hospital, Gainesville, Florida
Conditions: Sepsis, Trauma Injury
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LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis
NCT02205762
Recruiting
The LCH-IV is an international, multicenter, prospective clinical study for pediatric Langerhans Cell Histiocytosis LCH (age < 18 years).
Gender:
All
Ages:
18 years and below
Trial Updated:
03/21/2023
Locations: Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Conditions: Langerhans Cell Histiocytosis
Register for Updates
Prospective Multi-Center Randomized Study for Evaluating the EVAHEART®2 Left Ventricular Assist System
NCT01187368
Recruiting
This is a prospective, multi-center, unblinded, randomized, controlled, and non-inferiority study comparing the EVA2 LVAS to the most recent magnetically levitated centrifugal LVAS (HM3 LVAS).
Gender:
All
Ages:
18 years and above
Trial Updated:
03/20/2023
Locations: UF Health Shands Hospital, Gainesville, Florida
Conditions: Heart Failure
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Ortho-R® for Rotator Cuff Repair Compared With Standard of Care Rotator Cuff Repair Without Ortho-R®
NCT05333211
Recruiting
Phase I/II, multi-center, prospective, blinded 2arm, parallel design and randomized controlled study. Assessing the Ortho-R/PRP combination and standard of care for rotator cuff repair, will be compared though 12 months.
Gender:
All
Ages:
Between 40 years and 75 years
Trial Updated:
03/17/2023
Locations: Holy Cross Orthopedic Research Institute, Fort Lauderdale, Florida
Conditions: Rotator Cuff Tears
Register for Updates
Physica System Total Knee Replacement Registry Study
NCT03048201
Recruiting
The primary objective of this study is to obtain long-term implant survivorship (out to 10 years) and to assess clinical, patient-reported outcome measures, and radiographic data for the commercially available Physica system. For ancillary arm, from baseline to 5-year follow-up.
Gender:
All
Ages:
22 years and above
Trial Updated:
03/17/2023
Locations: The Orthopedics Clinic, Daytona Beach, Florida
Conditions: Osteoarthritis, Knee, Traumatic Arthritis, Avascular Necrosis, Degenerative Joint Disease of Knee, Rheumatoid Arthritis, Deformity of Knee
Register for Updates