Florida is currently home to 3730 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Miami, Tampa, Jacksonville and Orlando. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
ALG.APV-527 First-in-human Study
NCT05934539
Recruiting
A first-in-human, multicenter, open-label, dose escalation and dose expansion phase 1 study in patients with advanced solid tumors to evaluate the safety of intravenously administered ALG.APV-527 (Short title: ALG.APV-527 first-in-human study). Adult patients with advanced/metastatic solid tumors likely to express 5T4 antigen who have failed standard of care regimens for their cancer, have become refractory to standard treatment, or for whom no effective therapy exists based on investigator judg... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/28/2023
Locations: Hematology Oncology Associates Of The Treasure Coast, Port Saint Lucie, Florida
Conditions: Solid Tumor
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Diabetic Foot Ulcers-Comparing Transforming Powder to Standard of Care
NCT05046158
Recruiting
Phase IV, randomized, prospective, multi-center, open-label, comparison of transforming powder dressing to standard of care dressing for healing diabetic foot ulcers.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
06/27/2023
Locations: AdventHealth Medical Group Foot & Ankle at Winter Park, Winter Park, Florida
Conditions: Diabetic Foot Ulcer
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Neoplastic Barrett Esophagus: Endoscopic Piecemeal vs. En Bloc Resection
NCT03427346
Recruiting
The study will compare EMR versus ESD technique (both combined with subsequent ablative therapy) of mucosal resection in Barrett's esophagus with regard to efficacy and risk in a long term setting.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
06/27/2023
Locations: Orlando Health, Orlando, Florida
Conditions: Barrett Esophagus, Barrett Adenocarcinoma, Esophagus Neoplasm
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Electromagnetic Fields Versus Placebo For Child-Pugh A and B Patients With Advanced Hepatocellular Carcinoma
NCT04797884
Recruiting
The primary goals of this study are to compare overall survival and quality of life in subjects with Child-Pugh A or B advanced hepatocellular carcinoma when treated with a device emitting radiofrequencies modulated at specific frequencies or with a device emitting unmodulated radiofrequencies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/25/2023
Locations: Tampa General Hospital, Tampa General Cancer Center, Tampa, Florida
Conditions: Hepatocellular Carcinoma
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A Diagnostic Study of CD38-Targeted ImmunoPET of Myeloma
NCT04814615
Recruiting
Evaluation of myeloma disease burden is currently suboptimal. This limits treatment planning and evaluation of residual disease following treatment. 89Zr-DFO-daratumumab is a novel immunoPET tracer, designed to detect CD38 on myeloma cells and allow visualization of myeloma in a PET scanner. A phase I study of 89Zr-DFO-daratumumab demonstrated safety and successful visualization of myeloma with 89Zr-DFO-daratumumab. This will be a phase II study of 89Zr-DFO-daratumumab to evaluate potential clin... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
06/23/2023
Locations: University of Miami, Miami, Florida
Conditions: Multiple Myeloma
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Photobiomodulation for Myofascial Pelvic Pain
NCT05926752
Recruiting
The goal of this clinical trial is to evaluate the efficacy of photobiomodulation of the pelvic floor muscles in female Veterans with chronic pelvic pain. The main questions it aims to answer are: * Is there a difference in reduction in overall pelvic pain between women who undergo photobiomodulation compared to women who received pelvic floor physical therapy? * Is there a difference in compliance with therapy between the two groups? Participants will be randomized to treatment with either 9 t... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
06/21/2023
Locations: Orlando VA Medical Center, Orlando, Florida
Conditions: Pelvic Pain, Levator Ani Syndrome, Spastic Pelvic Floor Syndrome, Chronic Pelvic Pain Syndrome, Myalgia of Pelvic Floor
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LF111 or Drospirenone Chew vs Non-hormonal Contraceptive Methods on Bone Mineral Density in Adolescent and Adult Women
NCT05303636
Recruiting
The primary objective of this study is to evaluate the impact of LF111 and drospirenone (DRSP) 3.5 mg chewable tablets on bone mineral density (BMD) at the lumbar spine after 12 months (13 medication cycles) of investigation in comparison to non-hormonal contraceptive methods. Secondary objectives include further evaluating the impact of LF111 and DRSP 3.5 mg chewable tablets on BMD and bone turnover after 12 months (13 medication cycles) in comparison to non-hormonal contraceptive methods and a... Read More
Gender:
FEMALE
Ages:
Between 14 years and 45 years
Trial Updated:
06/15/2023
Locations: Advanced Clinical Research Network, Coral Gables, Florida
Conditions: Change in Bone Mineral Density, Bone Loss
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A Rapid Diagnostic of Risk in Hospitalized Patients Using Machine Learning
NCT05893420
Recruiting
In this study, the investigators will deploy a software-based clinical decision support tool (eCARTv5) into the electronic health record (EHR) workflow of multiple hospital wards. eCART's algorithm is designed to analyze real-time EHR data, such as vitals and laboratory results, to identify which patients are at increased risk for clinical deterioration. The algorithm specifically predicts imminent death or the need for intensive care unit (ICU) transfer. Within the eCART interface, clinical tea... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/06/2023
Locations: BayCare Health System, Clearwater, Florida
Conditions: Sepsis, Septicemia, Respiratory Failure, Hemodynamic Instability, COVID-19, Cardiac Arrest, Clinical Deterioration
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Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE TAVR)
NCT04827238
Recruiting
The DISCORDANCE TAVR study will determine the discordance between echocardiography-derived and invasive transaortic gradients, as determined by a consistent and reproducible technique (Standardized Invasive Hemodynamics) post-TAVR.
Gender:
ALL
Ages:
All
Trial Updated:
06/06/2023
Locations: Tenet Health, Boca Raton, Florida
Conditions: Aortic Stenosis, Aortic Valve Stenosis
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SBRT +/- Pembrolizumab in Patients With Local-Regionally Recurrent or Second Primary Head and Neck Carcinoma
NCT03546582
Recruiting
This phase II trial with a safety run-in component will evaluate whether the addition of pembrolizumab to Stereotactic Body Radiation Therapy (SBRT) re-irradiation will improve the progression-free survival for patients with recurrent or new second primary Head and Neck Squamous Cell Carcinoma (HNSCC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/01/2023
Locations: Moffitt Cancer Center, Tampa, Florida
Conditions: Head and Neck Squamous Cell Carcinoma (HNSCC)
Register for Updates
Natural History Study of and Genetic Modifiers in Spinocerebellar Ataxias
NCT01060371
Recruiting
Spinocerebellar ataxias (SCA) are genetic neurological diseases that cause imbalance, poor coordination, and speech difficulties. There are different kinds of SCA and this study will focus on types 1, 2,3, and 6 (SCA 1, SCA 2, SCA 3 , also known as Machado-Joseph disease and SCA 6). The diseases are rare, slowly progressive, cause increasingly severe neurological difficulties and are variable across and within genotypes. The purpose of this research study is to bring together a group of experts... Read More
Gender:
ALL
Ages:
6 years and above
Trial Updated:
05/30/2023
Locations: University of Florida, Gainesville, Florida
Conditions: Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2, Spinocerebellar Ataxia Type 3, Spinocerebellar Ataxia Type 6
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PTSD, AUD, and Interpersonal Conflict: Within-person Associations
NCT04552782
Recruiting
The present study seeks to increase understanding of Alcohol Use Disorder (AUD) and Posttraumatic Stress Disorder (PTSD) among veterans, an important public health concern. We will study the effects of regulatory deficits and sleep disturbance on the dynamic course of PTSD and AUD. The study will investigate whether a short, computerized training in the laboratory will alter maladaptive response biases and reduce associations between sleep disturbance, affect and behavioral dysregulation, AUD sy... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
05/08/2023
Locations: Bay Pines VA Health Care System, Bay Pines, Florida
Conditions: Stress Disorders, Post-Traumatic, Alcoholism
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