Florida is currently home to 3819 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Miami, Tampa, Jacksonville and Orlando. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Baby 2 Baby Beneficial Bacteria
Recruiting
The investigators will recruit mother-infant dyads to attend weekly lactation support groups and randomize infants to receive either an HMO consuming or non-HMO consuming probiotic. The investigators will collect infant stool before and after support group attendance. The investigators will use qPCR and metagenomic sequencing to test if the study probiotics or other bacteria transmit between infants. The investigators anticipate HMO consuming bacteria will and non-HMO consuming bacteria will not... Read More
Gender:
ALL
Ages:
Between 18 years and 62 years
Trial Updated:
02/05/2024
Locations: University of Florida, Gainesville, Florida
Conditions: Transmission
Study of AC699 in Patients With Estrogen Receptor Positive/Human Epidermal Growth Factor Receptor 2 Negative (ER+/HER2-) Locally Advanced or Metastatic Breast Cancer
Recruiting
This clinical trial is evaluating a drug called AC699 in participants with estrogen receptor positive/human epidermal growth factor 2 negative (ER+/HER2-) locally advanced or metastatic breast cancer. The main goals of this study are to: * Identify the recommended dose of AC699 that can be given safely to participants * Evaluate the safety profile of AC699 * Evaluate the pharmacokinetics of AC699 * Evaluate the effectiveness of AC699
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2024
Locations: Site 02, Sarasota, Florida
Conditions: Breast Cancer
Symbiotic Use in Post-Bariatric Surgery Patients
Recruiting
The purpose of this double blind, randomized control trial would be to test the efficacy of a once daily, multi strain symbiotic on gut health changes in weight loss surgery patients by testing stool samples prior to administration and then three months post administration of the symbiotic to monitor any changes in bacteria in the stool samples. Study participants will also complete a survey that evaluates their bowel habits, stool consistency, and gastrointestinal related symptoms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/01/2024
Locations: University of North Florida, Jacksonville, Florida
Conditions: Bariatric Surgery Candidate
Safety, Tolerability and Pharmacokinetics of a Monoclonal Antibody Specific to B-and T-Lymphocyte Attenuator (BTLA) as Monotherapy and in Combination With an Anti-PD1 Monoclonal Antibody for Injection in Subjects With Advanced Malignancies
Recruiting
The primary objective is to assess the safety and tolerability of TAB004 as monotherapy and in combination with toripalimab in subjects with selected advanced solid malignancies, including lymphoma, and to evaluate the recommended Phase 2 dose. The secondary objectives are to: 1) describe the pharmacokinetic (PK) profile of TAB004 monotherapy and in combination with toripalimab and to describe the PK profile of toripalimab when administered with TAB004, 2) evaluate antitumor activity of TAB004... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/01/2024
Locations: Boca Raton Clinical Research (BRCR), Boca Raton, Florida
Conditions: Advanced Unresectable Solid Tumor, Metastatic Solid Tumor
The Acute Burn ResUscitation Multicenter Prospective Trial
Recruiting
This is a prospective randomized multi-center study which will compare acute fluid resuscitation using a colloid strategy (LR + 5% Albumin) to a crystalloid strategy (LR alone), in adults with an acute burn involving at least 25% of their total body surface area.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/31/2024
Locations: University of Florida Health, Gainesville, Florida
Conditions: Burn Injury
Study Evaluating Safety and Efficacy of UCART123v1.2 in Patients With Relapsed/Refractory Acute Myeloid Leukemia
Recruiting
Phase I, open-label, dose-escalation and dose-expansion study evaluating the safety and efficacy of Universal Chimeric Antigen Receptor T-cell (UCART) targeting the Cluster of Differentiation 123 (CD123) in patients with relapsed/refractory acute myeloid leukemia (AML). The purpose of this study is to evaluate the safety and clinical activity of Universal Chimeric Antigen Receptor T-cells targeting CD123 (UCART123v1.2) and determine the Maximum Tolerated Dose (MTD) and Recommended Phase 2 Dose (... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/31/2024
Locations: Sylvester Comprehensive Cancer Center, Miami, Florida
Conditions: Relapsed/Refractory Acute Myeloid Leukemia
Sensory Intervention for Children With Autism
Recruiting
Greater than 80% of children with autism spectrum disorder (ASD) experience sensory differences that make it difficult for them to fully participate in meaningful everyday activities. In this research study, we will use MRI and behavioral methods to assess how sensory interventions might change sensory brain structures, allowing us to better predict which sensory interventions might work best for whom.
Gender:
MALE
Ages:
Between 6 years and 9 years
Trial Updated:
01/30/2024
Locations: University of Florida, Gainesville, Florida
Conditions: Autism Spectrum Disorder
Registry of Patients Undergoing Endoscopic Management of Pancreatic Fluid Collections
Recruiting
Acute pancreatitis is one of the most common gastrointestinal disorders requiring hospitalization worldwide. Pancreatic fluid collections can occur as a consequence of acute and chronic pancreatitis and can result in significant morbidity and mortality, including significant abdominal pain, gastric outlet obstruction, biliary obstruction, organ failure, persistent unwellness, infection and sepsis. Symptomatic pancreatic fluid collections require treatment, and endoscopic drainage is considered... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/29/2024
Locations: Orlando Health, Orlando, Florida
Conditions: Acute Pancreatitis, Pancreatic Pseudocyst, Pancreatic Necrosis
Rectal Indomethacin to Prevent Acute Pancreatitis in EUS-FNA of Pancreatic Cysts
Recruiting
The aim of this randomized trial is to compare the rate of post-procedure pancreatitis in patients undergoing EUS-FNA of pancreatic cysts; patients will receive either a single dose of indomethacin or placebo administered rectally, during EUS-FNA.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/29/2024
Locations: Orlando Health, Orlando, Florida
Conditions: Pancreatic Cyst, Pancreatitis, Acute
LE as a Marker for Periprosthetic Joint Infection
Recruiting
Testing and comparison of a novel point-of-care electrochemical assay to detect and help diagnose periprosthetic joint infection on the hip and knee to the standard of care test
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/29/2024
Locations: Cleveland Clinic Florida, Weston, Florida
Conditions: Prosthetic-joint Infection
Evaluation of Dupilumab in Patients With Atopic Keratoconjunctivitis (AKC)
Recruiting
This is a multi-center, double-masked, randomized, placebo-controlled, parallel-group, efficacy, safety, and tolerability study evaluating the efficacy of Dupilumab in the treatment of signs and symptoms of atopic keratoconjunctivitis (AKC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/29/2024
Locations: Encore Medical Research, LLC, Hollywood, Florida
Conditions: Atopic Keratoconjunctivitis
Alpha-1 Research Registry
Recruiting
The Alpha-1 Research Registry is a confidential database made up of individuals diagnosed with Alpha-1 Antitrypsin Deficiency (Alpha-1) and individuals identified as Alpha-1 carriers. The Registry was established to facilitate research initiatives and promote the development of improved treatments and a cure for Alpha-1.
Gender:
ALL
Ages:
All
Trial Updated:
01/29/2024
Locations: Alpha-1 Foundation, Coral Gables, Florida
Conditions: Alpha 1-Antitrypsin Deficiency