Maryland is currently home to 2846 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Vaginal Estradiol vs Oral Beta-3 Agonist for Overactive Bladder Syndrome
NCT05221021
Recruiting
A single site, double-blinded, randomized controlled trial for postmenopausal women with urinary frequency, urgency, nocturia with or without urgency urinary incontinence symptoms. Patient's will be randomized between 0.01% vaginal estradiol cream with placebo oral pill or daily 50 milligrams oral Mirabegron with a placebo vaginal cream for 12 weeks.
Gender:
Female
Ages:
18 years and above
Trial Updated:
11/03/2022
Locations: Walter Reed National Military Medical Center, Bethesda, Maryland
Conditions: Overactive Bladder Syndrome
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HCRN Core Data Project: Characterizing Patient Populations in the Hydrocephalus Clinical Research Network (HCRN)
NCT00670735
Recruiting
The Hydrocephalus Clinical Research Network (HCRN) has been established by philanthropic funding to conduct multi-institutional research (clinical trials and observational studies) on pediatric hydrocephalus. In addition to philanthropic funding, the HCRN has also received an NIH NINDS Challenge Grant to support the network infrastructure which allows for the conduct of this and other network studies. The HCRN consists of multiple Clinical Centers and the Data Coordinating Center (DCC). The HCRN... Read More
Gender:
All
Ages:
18 years and below
Trial Updated:
11/02/2022
Locations: Johns Hopkins Children's Center, Baltimore, Maryland
Conditions: Pediatric Hydrocephalus
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A Study of Belantamab Mafodotin Monotherapy in Multiple Myeloma Participants With Normal and Varying Degree of Impaired Renal Function
NCT04398745
Recruiting
Belantamab mafodotin is an antibody-drug conjugate (ADC) containing humanized anti- B-cell maturation antigen (BCMA) monoclonal antibody (mAb). Renal impairment is a major complication of multiple myeloma (MM) and the majority of MM participants is either at risk or already has renal dysfunction at initial diagnosis. The purpose of this study is to assess the pharmacokinetics (PK), safety, and tolerability of belantamab mafodotin monotherapy in participants with RRMM, who have had at least 3 lin... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/01/2022
Locations: GSK Investigational Site, Baltimore, Maryland
Conditions: Multiple Myeloma
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Rhenium Re 188 P2045 in Patients With Lung Cancer Who Have Received or Refused to Receive Prior Chemotherapy
NCT00100256
Recruiting
The purpose of this study is to determine the maximum dose that is safely tolerated of the experimental drug Rhenium Re 188 P2045. This will be done by first treating patients at relatively low doses of Rhenium Re 188 P2045, observing them closely to assure that there are no bad side effects, then increasing the dose when we are confident that it is safe to do so.
Gender:
All
Ages:
21 years and above
Trial Updated:
10/31/2022
Locations: Not set, Baltimore, Maryland
Conditions: Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Small Cell, Neoplasm Recurrence, Local
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2-level Cervical Disc Replacement Comparing Prodisc C SK & Vivo to Mobi-C
NCT04012996
Recruiting
A multi-center, prospective, randomized, controlled comparison of the prodisc C SK and prodisc C Vivo to the control, a similar, legally marketed total disc replacement device in subjects with symptomatic cervical disc disease (SCDD).
Gender:
All
Ages:
Between 18 years and 69 years
Trial Updated:
10/27/2022
Locations: University of Maryland Medical Center, Baltimore, Maryland
Conditions: Symptomatic Cervical Disc Disease
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A Study to Evaluate LB1148 for Return of Gastrointestinal Function and Adhesions in Subjects Undergoing Bowel Resection
NCT02836470
Recruiting
The purpose of this study is to establish preliminary evidence of the efficacy, safety, and tolerability of LB1148 for the treatment of post-operative ileus and intra-abdominal adhesions in subjects undergoing elective bowel resection.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
10/27/2022
Locations: Site 321, Baltimore, Maryland
Conditions: Ileus, Post-Operative Adhesions
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Connect® Myeloid Disease Registry
NCT01688011
Recruiting
The purpose of the Connect® Myeloid disease registry is to provide unique insights into treatment decisions and treatment patterns as they relate to clinical outcomes of patients with myeloid diseases in routine clinical practice. This disease registry will also evaluate molecular and cellular markers that may provide further prognostic classification which may or may not be predictive of therapy and clinical outcomes.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/25/2022
Locations: Weinberg Cancer Institute at Franklin Square, Baltimore, Maryland
Conditions: Myelodysplastic Syndromes, Primary Myelofibrosis, Leukemia, Myeloid, Acute
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MDMA-assisted Therapy for Adjustment Disorder (AD) in Dyads of Patients With Cancer and a Concerned Significant Other
NCT05584826
Recruiting
The goal of this clinical trial is to assess feasibility, tolerability and preliminary effectiveness of MDMA-assisted therapy for adjustment disorder (AD) in 10 dyads of patients with cancer and a concerned significant other (CSO) (20 participants total). Participants will undergo an 8-week treatment period which will include two doses of MDMA, two Preparatory Sessions and four Integrative Sessions of non-drug therapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/13/2022
Locations: Sunstone Medical, PC, Rockville, Maryland
Conditions: Cancer, Adjustment Disorders
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Clinical Trial To Evaluate Safety And Efficacy Of KT-301 (Formerly US-APR2020) In Subjects With Chronic Kidney Disease Stage IV
NCT04913272
Recruiting
The aim of this Phase 2 study is to evaluate the safety and efficacy of the live biotherapeutic product, KT-301 (formerly US-APR2020), in the management of patients with CKD Stage IV.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
10/11/2022
Locations: Jadedstone Clinical Research, Silver Spring, Maryland
Conditions: Chronic Kidney Disease stage4
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Study of TL-895 in Subjects With Myelofibrosis
NCT04655118
Recruiting
This study evaluates TL-895, a potent, orally-available and highly selective irreversible tyrosine kinase inhibitor for the treatment of Myelofibrosis. Participants must be relapsed/refractory (e.g., having failed prior therapy), intolerant, or ineligible to receive JAKi treatment.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/11/2022
Locations: University of Maryland, Baltimore, Maryland
Conditions: Myelofibrosis
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Cigarette Smoking in Smokers With and Without Schizophrenia
NCT04001114
Recruiting
Higher rates and severity of tobacco dependence in people with schizophrenia, as compared with the general population, contribute to the lower life expectancy seen in this population. Dependent tobacco smoking is controlled by how different aspects of cigarette smoking are perceived. There is evidence suggesting that people with schizophrenia differ in how they perceive cigarette smoking, which, if confirmed, would have implications for tailoring treatment interventions for smoking cessation in... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
10/07/2022
Locations: Maryland Psychiatric Research Center, Catonsville, Maryland
Conditions: Tobacco Dependence, Schizophrenia
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Critical Health Assessment and Outcomes Score/Study
NCT02766166
Recruiting
CHAOS is based on the investigator's new and exciting results from pre-clinical and large longitudinal multi-center observational clinical studies of critically ill patients and asymptomatic community-based adults with little or no advanced disease. By integrating approaches from the physical, biological, computational, statistical and clinical sciences, this observational study will test the hypothesis that early diagnosis of subclinical signatures of critical illness encoded within physiologi... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/07/2022
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Critical Illness, Death, Sudden
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