Cerebrotendinous Xanthomatosis (CTX) Prevalence Study
NCT02638220
Recruiting
This is an observational, multicenter study to determine the prevalence of Cerebrotendinous Xanthomatosis (CTX) in patient populations diagnosed with early-onset idiopathic bilateral cataracts. Patients who are potentially eligible for study participation will be identified through a chart review of patients who were seen at each study site prior to that site's initiation, or by entering care at the site while the site is participating in the trial.
Gender:
All
Ages:
Between 2 years and 21 years
Trial Updated:
11/07/2018
Locations: University of Maryland Baltimore, Baltimore, Maryland
Conditions: Cerebrotendinous Xanthomatosis (CTX)
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Treatment of Type 2 Diabetes With Ketogenic Diet
NCT03652649
Recruiting
The purpose of the study is to evaluate the efficacy and safety of ketogenic diet (KD) complete meal replacement treatment of obesity-related Type 2 diabetes mellitus (T2DM) and of obesity in patients with obesity and T2DM. This will be an open-label single arm study evaluating glycemic control and weight loss in obese participants with type 2 diabetes treated for 6 months with 3:1 [fat]:[protein+carbohydrate] ratio, 1600 kcal/day diet.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
08/28/2018
Locations: Ivana Tyrlikova, Bethesda, Maryland
Conditions: Type2 Diabetes Mellitus, Obesity
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Prospective Outcomes Study: Vectra® DA Guided Care Compared to Usual Care
NCT02832297
Recruiting
In this 12-month multi-center prospective, site-randomized, two-arm trial, approximately 318 biologic-naïve subjects with RA who are candidates for treatment intensification due to inadequate response to MTX monotherapy will be enrolled at up to 60 study sites.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
07/27/2018
Locations: Rheumatology Associates of Baltimore, Baltimore, Maryland
Conditions: Arthritis, Rheumatoid
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Treatment of Leishmaniasis With Impavido® (Miltefosine): Pregnancy Registry
NCT02427308
Recruiting
The purpose of this observational study is to fulfill FDA Post Marketing Requirement (PMR) 2127-1 for miltefosine (NDA204684): implement a pregnancy registry for the time period Mar 2015-Mar 2024. This study is a prospective observational study in which female patients undergoing Impavido who become pregnant during treatment or within 5 months after completing treatment can volunteer to provide information about their pregnancy and the outcome of the pregnancy.
Gender:
Female
Ages:
All
Trial Updated:
03/06/2018
Locations: Fast Track, North Potomac, Maryland
Conditions: Leishmaniasis or Other Uses of Miltefosine
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Apremilast in Combination With Clobetasol Spray for the Treatment of Plaque Psoriasis
NCT03453190
Recruiting
Researchers want to find out if giving the drug Apremilast in combination with Clobetasol spray can help people clear their moderate to severe plaque psoriasis quicker than if Apremilast is used by itself.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/26/2018
Locations: Washington Dermatology Center, Rockville, Maryland
Conditions: Psoriasis
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Efficacy of Adjuvant Mitotane Treatment (ADIUVO)
NCT00777244
Recruiting
Study Rationale Adrenocortical carcinoma (ACC) is a very rare disease with a high risk of relapse after radical surgery. The efficacy of adjuvant mitotane treatment is suggested by a retrospective multicenter international study showing that postoperative mitotane treatment was associated with a significant reduction of the risk of relapse and death. However, these promising results need confirmation in a randomized prospective study. Caution should be adopted particularly in patients with low r... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/04/2017
Locations: Medical Oncology Branch - Center for Cancer Research - National Cancer Institute, Bethesda, Maryland
Conditions: Adrenocortical Carcinoma
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Exercise and Brain Health
NCT02626442
Recruiting
The risk of stroke and vascular dementia is high in individuals who have had a prior stroke or TIA, and in those who have vascular disease risk factors, such as high blood pressure, abnormal cholesterol, diabetes or pre-diabetes. These vascular risk factors can improve with exercise. This study will examine the impact of a 6 month, low intensity group exercise class on fitness, walking, balance, and brain health. This study will also collect fitness, walking, balance, and brain health outcome m... Read More
Gender:
All
Ages:
Between 18 years and 95 years
Trial Updated:
10/28/2016
Locations: Baltimore VA Medical Center, Baltimore, Maryland
Conditions: Stroke, Cardiovascular Risk Factors, Transient Ischemic Attack (TIA)
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Efficacy of Implantable Defibrillator Therapy After a Myocardial Infarction
NCT00673842
Recruiting
This study will assess whether an implantable defibrillator will increase the likelihood of survival in patients who have had a heart attack in the prior 5 years, have abnormal test results from a 24 hour heart monitor, and who have low normal heart function.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
07/07/2016
Locations: Delmarva Heart Foundation, Salisbury, Maryland
Conditions: Myocardial Infarction, Sudden Death
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