Massachusetts is currently home to 3158 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Regulation of Emotion, Sleep Extension, and MTBI
NCT06883006
Recruiting
Concussions are incredibly common, and often result in severe and long lasting symptoms, including, but not limited to, sleep deprivation and emotion dysregulation. This study aims to demonstrate the therapeutic benefits of sleep extension (napping) on emotion regulation in individuals after they sustain a concussion. Thus, sleep extension may be a cost-effective, low risk, supplemental treatment for those with emotion dysregulation following a concussion. The main questions it aims to answer ar... Read More
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
03/12/2025
Locations: Merrimack College, North Andover, Massachusetts
Conditions: Mild Traumatic Brain Injury
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Program for Alleviating and Reducing Trauma and Stress for Intimate Partner Violence
NCT06765122
Recruiting
This research study investigates the feasibility and acceptability of a group-based treatment program for reducing stress, trauma, substance use, and use of violence among individuals who were court-mandated to attend a program after committing an act(s) of domestic violence.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: Cambridge Health Alliance Center for Mindfulness and Compassion, Malden, Massachusetts
Conditions: Interpersonal Violence
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Treatment for Individuals Interacting with the Criminal Justice System
NCT06564948
Recruiting
The proposed Center will leverage burgeoning real-time data linkage capabilities among health systems, Medicaid payors, and criminal legal (e.g., jail booking data, jail release data) systems, to identify individuals coming in and out of jail for suicide assessment and prevention, and to better coordinate care across these disparate systems. This Center will advance the fields of suicide prevention and criminal legal system-based mental health by solving a well-known, central problem in both fie... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
03/12/2025
Locations: Cambridge Health Alliance, Cambridge, Massachusetts
Conditions: Suicide Risk, Psychiatric Disorders
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Our Whole Lives Gemini: Virtual Integrative Medical Group Visits for Managing Chronic Pain
NCT06515925
Recruiting
The goal of this research study is to test the efficacy of a non-prescription medicine, web-based platform solution for patients with chronic pain, to improve pain self-management and related outcomes. The main question investigators aim to answer is; would the use of this web-based intervention plus an online group visit compared to control result in better pain-related outcomes and improved pain impact?
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: Cambridge Health Alliance Center for Mindfulness and Compassion, Malden, Massachusetts
Conditions: Chronic Pain
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Web-based Mind-body Program for Comorbid Nontraumatic Upper-extremity Condition and Risky Substance Use
NCT06366633
Recruiting
The investigator aims to conduct an open pilot study (N=12; 10 completers) to test the feasibility, acceptability, and credibility of an asynchronous web-based mind-body intervention (Toolkit for Resilient Life beyond Pain and Substance Use; Web-TIRELESS) for adult patients with a comorbidity of non-traumatic painful upper-extremity condition(s) (NPUC) and risky substance use. Deliverables: 1) Adapt and refine open pilot protocol, patient recruitment, and other study materials. 2) Assess the fe... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: Massachusetts General Hospital (MGH), Boston, Massachusetts
Conditions: Orthopedic Disorder, Nontraumatic Injury, Substance Use, Upper Extremity Problem
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Prospective Screening for Pancreatic Ductal Adenocarcinoma in High-Risk Individuals
NCT06122896
Recruiting
The purpose of this research is to see if adding blood-based tests and symptom review to standard-of-care pancreatic cancer screening procedures can identify cancer early among individuals with increased risk.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma, PDAC, PDAC - Pancreatic Ductal Adenocarcinoma, Pancreatic Neoplasm
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Study to Evaluate Efficacy and Safety of Romosozumab Compared With Bisphosphonates in Children and Adolescents With Osteogenesis Imperfecta
NCT05972551
Recruiting
The primary objective of this study is to evaluate the effect of romosozumab treatment for 12-months compared with bisphosphonate(s) on the number of clinical fractures at 12-months; the number of any fractures at 12-months and change in lumbar spine bone mineral density (BMD) Z-score at 6-months.
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
03/12/2025
Locations: Boston Childrens Hospital, Boston, Massachusetts
Conditions: Osteogenesis Imperfecta
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Pembro Plus CAR T-cell Therapy in R/R in PMBCL
NCT05934448
Recruiting
This research study is evaluating the combination of drugs, pembrolizumab with chimeric antigen receptor (CAR) T-cell therapy, as a possible treatment for primary mediastinal B-cell lymphoma that has recurred after prior treatment. The names of the study drugs involved in this study are: - Pembrolizumab Standard treatment will include: * CAR T-cell therapy (either axicabtagene-ciloleucel or lisocabtagene maraleucel) * Cyclophosphamide * Fludarabine
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Primary Mediastinal Large B-cell Lymphoma (PMBCL), Primary Mediastinal Large B Cell Lymphoma, Primary Mediastinal Large B-Cell Lymphoma Refractory, Primary Mediastinal Large B-Cell Lymphoma Recurrent, Epstein-Barr Virus Positive Diffuse Large B-Cell Lymphoma, T-Cell/Histiocyte-Rich Large B-Cell Lymphoma
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Suicide Risk Interventions
NCT05931289
Recruiting
The suicide rate among active duty service members and Veterans increased substantially following the onset of post-9/11 conflicts in Iraq and Afghanistan. Accordingly, Veteran suicide prevention has been identified as a national healthcare and research priority. The investigators will recruit 136 female and male Veterans who have been hospitalized for suicide risk and randomly assign them to receive one of two psychotherapy treatments for suicide risk after they leave the hospital. The goals of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts
Conditions: Suicide
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Cardiac RADIoablation Versus Repeat Catheter Ablation: a Pivotal Randomized Clinical Trial Evaluating Safety and Efficacy for Patients With High-risk Refractory Ventricular Tachycardia (RADIATE-VT)
NCT05765175
Recruiting
RADIATE-VT is a pivotal, multicenter, randomized trial comparing safety and efficacy between cardiac radioablation (CRA) using the Varian CRA System and repeat catheter ablation (CA), for patients with high-risk refractory ventricular tachycardia (VT) who have experienced VT recurrence after CA and are candidates for additional CA.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: Brigham & Women's Hospital, Boston, Massachusetts
Conditions: Tachycardia, Ventricular
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Symptom Monitoring in Hemodialysis
NCT05738330
Recruiting
The SMaRRT-HD trial is a cluster randomized trial of symptom monitoring with supported clinician follow-up using the SMaRRT-HD electronic patient reported outcome measure (ePROM) system versus Usual Care. Approximately 2400 patients at 30 geographically and racially diverse US hemodialysis clinics will be enrolled. The primary trial hypothesis is that regular symptom patient reported outcome measure (PROM) administration with supported clinician follow-up in dialysis care will reduce suffering a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: Fresenius Medical Care, Waltham, Massachusetts
Conditions: End Stage Kidney Disease
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A Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus (CMV) Vaccine in Allogenic Hematopoietic Cell Transplantation (HCT) Participants.
NCT05683457
Recruiting
The main purpose of the study is to evaluate the efficacy and safety of mRNA-1647 compared to placebo to prevent first clinically significant cytomegalovirus infection (CS-CMVi) in the period following cessation of CMV prophylactic treatment (for example, letermovir) on Day 100 post-HCT through Month 9 post-HCT.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Cytomegalovirus Infection
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