Massachusetts is currently home to 3220 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
The Boston Pace Study
NCT05869500
Recruiting
Right ventricular (RV) pacing can cause left ventricular systolic dysfunction in 10- 20% of patients. Biventricular pacing had previously been shown to prevent left ventricular systolic dysfunction. However, implantation of coronary sinus lead increases procedural risk and can be limited by higher threshold and phrenic nerve capture. HIS pacing has been evaluated as an alternative pacing strategy, but its routine use was limited by difficulty of the procedure, success rate and high pacing thresh... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/16/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Left Bundle Branch Area Pacing
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ZYNRELEF® for Postoperative Analgesia After Laparoscopic Sleeve Gastrectomy
NCT05863221
Recruiting
Approximately 120 subjects will be randomized into 1 of the following 2 treatment groups in a 1:1 ratio: Group 1: ZYNRELEF® up to 200 mg/ 6mg ( 7ml vial) via instillation at all incision sites in addition to 30 ml of 0.5% Ropivacaine + 10mg dexamethasone. Postoperatively, intermittent IV acetaminophen will be administered as per need till discharge. Group 2: 30 ml of 0.5% Ropivacaine and 10mg dexamethasone into all surgical sites and intermittent IV acetaminophen as per need till discharge. P... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/16/2023
Locations: Holyoke Medical Center, Holyoke, Massachusetts
Conditions: Post Operative Pain, Acute, Bariatric Surgery Candidate, Postoperative Pain
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The T1D Exchange Registry
NCT04629586
Recruiting
The T1D Exchange Registry is a research study, conducted over time, for individuals with type 1 diabetes and their supporters. Participants volunteer to provide their data for research (for example, by answering questions in annual surveys). Once enrolled, Registry participants have the opportunity to sign up for other studies on various topics related to type 1 diabetes. To participate, you will be asked to: * Read and sign an online informed consent form * Take a survey describing specific d... Read More
Gender:
ALL
Ages:
All
Trial Updated:
05/04/2023
Locations: T1D Exchange, Boston, Massachusetts
Conditions: Diabetes Mellitus, Type 1, Diabetes, Type 1 Diabetes, Diabetes Mellitus
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Eye Movement Rehabilitation in Low Vision Patients
NCT04929756
Recruiting
Approximately 217 million people worldwide currently suffer from low vision, which impacts a broad range of activities of daily living and is associated with depression and increased mortality. Over half of the patients presenting for low vision services have eye disease that affects the fovea and surrounding macula and leads to central vision loss (CVL). People with CVL are forced to use eccentric vision as a substitute for their impaired fovea, however eye movement control and visual function... Read More
Gender:
ALL
Ages:
Between 14 years and 99 years
Trial Updated:
05/02/2023
Locations: NECO Center for Eye Care, Boston, Massachusetts
Conditions: Low Vision, Age Related Macular Degeneration
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Evaluation of PET Probe [68Ga]CBP8 in the Detection of Radiation Induced Tissue Injury
NCT04485286
Recruiting
The goal of this study is to investigate the efficacy of \[68Ga\]CBP8 to detect collagen deposition in radiation induced tissue injury.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
04/30/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Lung Cancer, Radiation Fibrosis, Radiation Induced Lung Injury, Pancreas Cancer
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KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment
NCT03662126
Recruiting
This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with myelofibrosis (MF) who no longer benefit from treatment with a JAK inhibitor. Inhibition of MDM2 is a novel mechanism of action in MF. This study will be conducted in 2 phases. Phase 2 will determine the KRT-232 recommended dose and dosing schedule; Phase 3 will test KRT-232 vs Best Available Therapy (BAT). Patients in the Phase 3 part of the study will be randomized 2:1 to receive ei... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/26/2023
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Primary Myelofibrosis (PMF), Post-Polycythemia Vera MF (Post-PV-MF), Post-Essential Thrombocythemia MF (Post-ET-MF)
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Intrinsic Foot Muscle Strengthening Interventions for Older Adults
NCT05829369
Recruiting
Falls are the leading cause of injury in adults over age 65. Muscle weakness in the foot can lead to foot and toe deformities such as collapsed arches or bunions, which have been found to contribute to falls in adults over age 65. The current research study aims to investigate the effectiveness of two simple and affordable foot strengthening methods that may make a major impact on balance and fall prevention in older adults.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
04/24/2023
Locations: Springfield College, Springfield, Massachusetts
Conditions: Accidental Fall
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NAD Augmentation in Diabetes Kidney Disease
NCT05759468
Recruiting
A phase 2a trial randomized, double-blind, placebo-controlled, parallel group trial to determine whether NMN administration improves DKD, as indicated by a significantly greater reduction in UACR compared with placebo administration. Eligible participants will be randomized to receive either 1000 mg NMN or placebo twice daily.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
04/21/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Type2diabetes, Diabetic Kidney Disease
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Molecular Analysis of Patients With Neuromuscular Disease
NCT00390104
Recruiting
The purpose of this study is to identify new genes responsible for neuromuscular disorders and study muscle tissue of patient with known neuromuscular disease, as well as their family members. We are interested in recruiting many types of neuromuscular disease including; Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), and limb-girdle muscle dystrophy (LGMD). There are still many patients diagnosed with muscular dystrophy with no causative gene implicated in their disease. Usi... Read More
Gender:
ALL
Ages:
Between 1 week and 100 years
Trial Updated:
04/20/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Limb-girdle Muscular Dystrophy, Neuromuscular; Disorder, Hereditary, Duchenne/Becker Muscular Dystrophy
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Using Machine Learning to Optimize User Engagement and Clinical Response to Digital Mental Health Interventions
NCT05567640
Recruiting
Digital mental health interventions are a cost-effective and efficient approach to expanding the accessibility and impact of psychological treatments; however, little guidance exists for selecting the most effective program for a given individual. In the proposed study, decision rules will develop for selecting the digital program that is most likely to be the optimal intervention for each user. These treatment recommendations can be implemented in the context of large healthcare delivery system... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/13/2023
Locations: Center for Anxiety and Related Disorders, Boston, Massachusetts
Conditions: Anxiety Disorders and Symptoms, Depressive Symptoms
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Patient-Centered Surgical Prehabilitation
NCT05715684
Recruiting
The purpose of this research is to validate the prehabilitation program which is defined as a set of interventions meant to prepare the body physically and nutritionally for the cystectomy procedure.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
03/20/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Bladder Cancer, Cystectomy
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Anti-VEGF Therapy for Acute Thyroid Eye Disease
NCT04311606
Recruiting
The primary objective of this clinical trial is to assess the safety and tolerability of sub-tenon aflibercept in combination with either saline or hyaluronidase (HA) in patients with acute Thyroid Eye Disease (TED) as assessed by the incidence and severity of adverse events from baseline to day 45. Participants will undergo clinical examinations and receive three injections of aflibercept with saline, aflibercept with hyaluronidase, or hyaluronidase.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/16/2023
Locations: Mass Eye and Ear, Boston, Massachusetts
Conditions: Thyroid Eye Disease
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