Massachusetts is currently home to 3202 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Pain and Itch Reduction in Burn Scars Treated With Fractional CO2 Laser
NCT04364217
Recruiting
Hypertrophic Burn Scars (HTBS) are often treated with Fractional CO2 laser therapy to improve cosmetic appearance. It has been noted that this leads to a reduction in the pain and itch associated with this type of scars. While this phenomenon is commonly described in the literature, the mechanism of pain and itch reduction in unclear. The investigators aim to better understand this process by histological evaluation of HTBS at different stages of laser treatment.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/28/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Hypertrophic Scar, Burn Scar
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Navtemadlin (KRT-232) With or Without Anti-PD-1/Anti-PD-L1 for the Treatment of Patients With Merkel Cell Carcinoma
NCT03787602
Recruiting
This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with Merkel Cell Carcinoma (MCC) who have failed treatment with at least one anti-PD-1 or anti-PD-L1 immunotherapy or in combination with avelumab in MCC patients who are anti-PD-1 or anti-PD-L1 treatment naïve. Inhibition of MDM2 is a novel mechanism of action in MCC.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/28/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Merkel Cell Carcinoma
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Assessing the Burden of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
NCT04880265
Recruiting
Background and Significance: In the United States approximately 220,000 patients undergo cardiac surgery per annum. Among potential complications, the incidence of atrial fibrillation (AF) is estimated at 30 - 60 %, and therefore presents the most common adverse event after cardiac surgery. Multiple complications may be associated with AF: Patients are usually subject to an increased length-of-stay in the intensive care unit and in the hospital. Furthermore, the risk for stroke and development... Read More
Gender:
ALL
Ages:
Between 20 years and 90 years
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Atrial Fibrillation, Cardiac Surgery
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Gene Expression Profiling in Subjects With Postoperative Atrial Fibrillation After Cardiac Surgery (GENEXPRO Surg)
NCT00833313
Recruiting
Atrial fibrillation is a type of irregular heartbeat that is common after having heart surgery. There may be many different reasons why some people get atrial fibrillation after their heart surgery. These reasons may include that a person is older or that he/she is taking certain types of medications before surgery. Genes may also be a reason. Genes contain the material passed from parent to child that determines the make-up of the body and mind. For example, some genes control the color of your... Read More
Gender:
ALL
Ages:
Between 20 years and 99 years
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Atrial Fibrillation
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Prospectively Collected Pleural Biopsies for Validation of Malignant Pleural Mesothelioma Prognostic Biomarkers
NCT03683680
Recruiting
This research study is evaluating a new method for determining stage and prognosis of individuals with malignant pleural mesothelioma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/23/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Mesothelioma
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Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression
NCT05450432
Recruiting
The study will consist of a 24-week-long trial examining outcomes in patients with Major Depressive Disorder and suicidal ideation who will receive intravenous (IV) ketamine and intranasal (IN) esketamine, compared to a large sample of matched historical controls. Patients will be recruited from an inpatient psychiatric unit. Eligible patients who provided informed consent will be enrolled in the study that will include a eight IV ketamine treatments, 13 esketamine treatment visits, seven long a... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
01/20/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Major Depressive Disorder
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Rett Syndrome Registry
NCT05432349
Recruiting
The Rett Syndrome Registry is a longitudinal observational study of individuals with MECP2 mutations and a diagnosis of Rett syndrome. Designed together with the IRSF Rett Syndrome Center of Excellence Network medical directors, this study collects data on the signs and symptoms of Rett syndrome as reported by the Rett syndrome experts and by the caregivers of individuals with Rett syndrome. This study will be used to develop consensus based guidelines for the care of your loved ones with Rett s... Read More
Gender:
ALL
Ages:
Between 0 years and 99 years
Trial Updated:
01/09/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Rett Syndrome, Rett Syndrome, Atypical, Genetic Disease, Genetic Diseases, X-Linked, Intellectual Disability, Neurobehavioral Manifestations, Neurologic Manifestations, Neurologic Disorder, Neurodevelopmental Disorders, Nervous System Diseases
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Transplantation of Autologously Derived Mitochondria Following Ischemia
NCT02851758
Recruiting
The investigators propose a robust therapeutic intervention to ameliorate myocardial ischemia/ reperfusion injury and significantly decrease morbidity and mortality in patients requiring extracorporeal membrane oxygenation (ECMO), by direct injection of autogeneic mitochondria into the ischemic myocardium.
Gender:
ALL
Ages:
17 years and below
Trial Updated:
01/09/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Extracorporeal Membrane Oxygenation Complication
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Hybrid Functional Electrical Stimulation Exercise to Prevent Cardiopulmonary Declines in High-level Spinal Cord Injury
NCT04458324
Recruiting
Over the past ten years, the Cardiovascular Research Laboratory at Spaulding has refined a unique form of exercise for those with spinal cord injuries (SCI). Functional Electrical Stimulation Row Training (FESRT) couples volitional arm and electrically controlled leg exercise, resulting in the benefits of large muscle mass exercise. However, despite the potential for enhancing aerobic capacity by training the denervated leg skeletal muscle via hybrid FES exercise, the inability to increase venti... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
01/03/2023
Locations: Spaulding Hospital Cambridge, Cambridge, Massachusetts
Conditions: Spinal Cord Injuries
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Investigation of Anatomical Correlates of Speech Discrimination
NCT01781039
Recruiting
Understanding speech is essential for good communication. Individuals with hearing loss and poor speech discrimination often have little success with hearing aids because amplifying sound improves audibility, but not clarity of the speech signal. The purpose of this study is to determine the relative importance of the sensory cells of the inner ear and auditory neurons on speech discrimination performance in quiet and in noise. This information may be used as a predictor of hearing aid benefit.... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
12/23/2022
Locations: Steward St. Elizabeth's Medical Center, Brighton, Massachusetts
Conditions: Sensorineural Hearing Loss
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RCT Study to Validate niPGT-A Clinical Benefit.
NCT04000152
Recruiting
Chromosomal aneuploidies are linked with spontaneous miscarriages and abnormal offspring in human pregnancies. In addition, some types of aneuploidies are reported to prevent implantation. Thus, there is a need to identify the embryos with highest implantation potential on in vitro fertilization (IVF) programs. Since embryo morphology and kinetics have a weak association with embryo ploidy, trophectoderm biopsy plus Next-Generation Sequencing (NGS) is becoming a very popular approach to determi... Read More
Gender:
FEMALE
Ages:
Between 20 years and 40 years
Trial Updated:
12/13/2022
Locations: Boston IVF Fertility Clinic, Boston, Massachusetts
Conditions: Aneuploidy, Chromosome Abnormality, Infertility
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First in Human Phase 1 Ascending Dose Study of PanChol in Healthy Volunteers
NCT05657782
Recruiting
This study is a first-in-human, Phase 1 study of the safety, tolerability, and immunogenicity of PanChol in healthy volunteers. There will be three modules in this clinical trial assessing dosing, safety, and immunogenicity: 1. a fixed dose-ranging module, 2. an adaptive dose-finding/optimization module, and 3. a placebo-controlled expansion module.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
12/11/2022
Locations: Brigham and Women's Hospital Vaccine Unit, Boston, Massachusetts
Conditions: Cholera, Cholera Vaccine Toxicity
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