New York is currently home to 4473 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including New York, Rochester, Bronx and Buffalo. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study of Ruxolitinib in Combination With Ulixertinib in People With Myelofibrosis
Recruiting
The researchers are doing this study to find out whether the combination of ruxolitinib and ulixertinib is a safe and effective treatment for people with myelofibrosis. The researchers will test different doses of ulixertinib to find the highest dose that causes few or mild side effects in participants when given in combination with ruxolitinib.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/08/2025
Locations: Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities), Commack, New York
Conditions: Myelofibrosis
EMAGINE 2.0 - Electromagnetic Field Ischemic Stroke - Novel Subacute Treatment
Recruiting
This is a multicenter study that will be conducted at approximately 20 centers and up to 30 centers, if the sample size will be increased following interim assessment. The Q Therapeutic System (BQ 3.0) is a wearable medical device that produces and delivers non-invasive, extremely-low-intensity and low-frequency, frequency-tuned electromagnetic fields in order to stimulate neuronal networks with the aim of reducing disability and promoting neurorecovery. The Q Therapeutic System (BQ 3.0) is in... Read More
Gender:
ALL
Ages:
Between 22 years and 80 years
Trial Updated:
01/08/2025
Locations: New York-Presbyterian Brooklyn Methodist Hospital Inpatient Rehabilitation Unit, Brooklyn, New York
Conditions: Ischemic Stroke
Ventral or Inguinal Hernia, Robotically Repaired With OviTex Mesh
Recruiting
This study is designed to evaluate the post-operative complications and hernia recurrence following the use of OviTex in subjects with ventral or inguinal hernias. Up to 160 subjects will participate in the study from up to 20 investigator sites.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
01/08/2025
Locations: St. Francis Hospital, Roslyn, New York
Conditions: Hernia, Ventral, Hernia, Inguinal
A Single Center Diagnostic, Cross-sectional Study of Coronary Microvascular Dysfunction
Recruiting
Among patients with stable ischemic heart disease who are referred for coronary angiography, a substantial proportion have non-obstructive coronary artery disease (CAD). Ischemia based on symptoms or stress testing may be due to coronary microvascular dysfunction in up to 40% of these patients. However, the mechanisms and optimal treatment of coronary microvascular dysfunction are unknown. Aberrant platelet activity and inflammation have been hypothesized as mechanisms of microvascular dysfuncti... Read More
Gender:
ALL
Ages:
Between 18 years and 125 years
Trial Updated:
01/08/2025
Locations: New York University School of Medicine, New York, New York
Conditions: Coronary Microvascular Disease, Ischemic Heart Disease, Myocardial Ischemia
Building Community Resilience Program
Recruiting
Established in 2021, NYCEAL consists of approximately 40 organizational partners and 120 Community Health Workers (CHWs). Over the next four years (2024-2028), NYCEAL will work with this network to implement the following intervention: Building Community Resilience Program (BCR). To assess the impact of this intervention, an implementation research framework will be used, and pre- and post-surveys conducted, and other process evaluation measures collected. Changes in outcomes measures such as st... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/07/2025
Locations: Icahn School of Medicine at Mount Sinai, New York, New York
Conditions: Resilience, Psychological, Burnout, Psychological, Stress, Psychological
Fatigue Reduction in Chronic Kidney Disease (CKD)
Recruiting
In this pilot trial, investigators will pilot test a cognitive behavioral intervention for acceptability and proof of concept for a larger future trial to be submitted for federal funding. This is a one-group design with qualitative and quantitative data collection integrated into the intervention.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/07/2025
Locations: NYU Langone Health, New York, New York
Conditions: Chronic Kidney Diseases, Fatigue
Using AI and Peer Coaching to Address Racial Disparities Among People Who Use Opioids
Recruiting
Black and Latinx people who use opioids are disproportionately impacted by opioid overdose deaths. The proposed study assesses the efficacy of an open source, multimodal artificial intelligence-driven texting tool combined with peer recovery coach-supported text contact that delivers social services, stigma reduction, health habitus, and patient navigation content addressing social determinants of health to enhance receipt of buprenorphine in primary care among emergency department-enrolled Blac... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
01/07/2025
Locations: NYC Health + Hospitals, Bronx, New York
Conditions: Opioid Use Disorder
DBS for Depression
Recruiting
The goal of this clinical trial is to demonstrate the feasibility and safety of deep brain stimulation in treatment resistant depression. The main questions it aims to answer are: * Is deep brain stimulation effective in treating treatment resistant depression? * Does deep brain stimulation improve overall clinical well-being and functioning? Participants will be implanted with a deep brain stimulation device. They will then be monitored over a 5-year period by using multiple questionnaires to... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/07/2025
Locations: Zucker Hillside Hospital, Queens, New York
Conditions: Treatment Resistant Depression
A Study of D3L-001 as Monotherapy in Subjects With HER2-Positive Advanced Solid Tumors
Recruiting
This first-in-human (FIH) study, multi-center, open-label, dose escalation and dose expansion Phase I study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity, and preliminary anti-tumor activity of D3L-001 in subjects with HER2-positive advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/07/2025
Locations: D3 Bio Investigative Site, New York, New York
Conditions: HER-2 Positive Advanced Solid Tumors
Multicenter Trial of Antibiotic Eluting Graft for Promoting New Bone Growth In/near Infected Bone Cavities
Recruiting
This is a pivotal, prospective, multi-center, randomized, concurrent control, patient and assessor-blinded study with two arms: a treatment arm (where subjects will be treated with the EP Granules with Tobramycin investigational device in the 1st stage of a staged revision for periprosthetic joint infection (PJIs), and a control arm (where subjects are treated with the standard-of-care revision for infected PJIs).
Gender:
ALL
Ages:
22 years and above
Trial Updated:
01/07/2025
Locations: Hospital for Special Surgery, New York, New York
Conditions: Periprosthetic Joint Infections
A Study of ASTX727 in People With Malignant Peripheral Nerve Sheath Tumors (MPNST)
Recruiting
The purpose of this study is to see whether the study drug ASTX727 is an effective treatment for people who have MPNST with a PCR2 mutation. ASTX727 is a combination of two drugs (cedazuridine and decitabine) that have been designed to target cancer cells with a PCR2 mutation and to disrupt the cells' ability to survive and grow. The study researchers think that the study drug allows decitabine to work better than decitabine given alone.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/07/2025
Locations: Memorial Sloan Kettering Commack (Limited Protocol Activities), Commack, New York
Conditions: Malignant Peripheral Nerve Sheath Tumors (MPNST)
Vaginal Cuff Anesthesia and Post-Operative Pain Medication Use
Recruiting
The purpose of this study is to determine whether an injection of a local anesthetic (Bupivacaine with epinephrine) in the vaginal cuff prior to closure would result in less immediate postoperative pain medication and increase patient comfort/satisfaction.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
01/06/2025
Locations: Flushing Hospital Medical Center, Flushing, New York
Conditions: Hysterectomy, Post Operative Analgesia