Florida is currently home to 3804 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Miami, Tampa, Jacksonville and Orlando. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Rapid Diagnostic of Risk in Hospitalized Patients Using Machine Learning
Recruiting
In this study, the investigators will deploy a software-based clinical decision support tool (eCARTv5) into the electronic health record (EHR) workflow of multiple hospital wards. eCART's algorithm is designed to analyze real-time EHR data, such as vitals and laboratory results, to identify which patients are at increased risk for clinical deterioration. The algorithm specifically predicts imminent death or the need for intensive care unit (ICU) transfer. Within the eCART interface, clinical tea... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/06/2023
Locations: BayCare Health System, Clearwater, Florida
Conditions: Sepsis, Septicemia, Respiratory Failure, Hemodynamic Instability, COVID-19, Cardiac Arrest, Clinical Deterioration
Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE TAVR)
Recruiting
The DISCORDANCE TAVR study will determine the discordance between echocardiography-derived and invasive transaortic gradients, as determined by a consistent and reproducible technique (Standardized Invasive Hemodynamics) post-TAVR.
Gender:
All
Ages:
All
Trial Updated:
06/06/2023
Locations: Tenet Health, Boca Raton, Florida
Conditions: Aortic Stenosis, Aortic Valve Stenosis
SBRT +/- Pembrolizumab in Patients With Local-Regionally Recurrent or Second Primary Head and Neck Carcinoma
Recruiting
This phase II trial with a safety run-in component will evaluate whether the addition of pembrolizumab to Stereotactic Body Radiation Therapy (SBRT) re-irradiation will improve the progression-free survival for patients with recurrent or new second primary Head and Neck Squamous Cell Carcinoma (HNSCC).
Gender:
All
Ages:
18 years and above
Trial Updated:
06/01/2023
Locations: Moffitt Cancer Center, Tampa, Florida
Conditions: Head and Neck Squamous Cell Carcinoma (HNSCC)
Natural History Study of and Genetic Modifiers in Spinocerebellar Ataxias
Recruiting
Spinocerebellar ataxias (SCA) are genetic neurological diseases that cause imbalance, poor coordination, and speech difficulties. There are different kinds of SCA and this study will focus on types 1, 2,3, and 6 (SCA 1, SCA 2, SCA 3 , also known as Machado-Joseph disease and SCA 6). The diseases are rare, slowly progressive, cause increasingly severe neurological difficulties and are variable across and within genotypes. The purpose of this research study is to bring together a group of experts... Read More
Gender:
All
Ages:
6 years and above
Trial Updated:
05/30/2023
Locations: University of Florida, Gainesville, Florida
Conditions: Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2, Spinocerebellar Ataxia Type 3, Spinocerebellar Ataxia Type 6
Matrion™ Decellularized Placental Membrane in Subjects With Diabetic Foot Ulcers
Recruiting
In this study, a novel placental membrane product Matrion™ (LifeNet Health, Inc., Virginia Beach, VA) will be used as a treatment for subjects with diabetic foot ulcers. Matrion is composed of placental membrane derived from donated human birth tissue containing both the innermost amniotic layer and the outermost chorionic layer, inclusive of the trophoblast layer. Matrion is minimally processed and disinfected using a proprietary decellularization technology and terminally sterilized that safel... Read More
Gender:
All
Ages:
Between 21 years and 80 years
Trial Updated:
05/19/2023
Locations: Doctors Research Network, Miami, Florida
Conditions: Diabetic Foot, Lower Extremity Wound
A Study to Assess the Pharmacodynamics of VK0214 in Male Subjects With AMN
Recruiting
Subjects will be administered multiple doses of VK0214 in a cohort dose escalation process. A total of up to 36 subjects will be enrolled in the study, into one of three dose cohorts. For each cohort, up to 12 subjects will be randomized to receive VK0214 or placebo in a 3:1 ratio so that there will be a total of up to 9 subjects for each of the active doses and up to 3 subjects dosed with placebo in each cohort.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/18/2023
Locations: Viking Clinical Site 207, Gainesville, Florida
Conditions: Adrenomyeloneuropathy Form (AMN) of X-linked Adrenoleukodystrophy (X-ALD)
JAB-3312 Based Combination Therapy in Adult Patients With Advanced Solid Tumors
Recruiting
To evaluate the safety and tolerability of JAB-3312 administered in investigational regimens in adult participants with advanced solid tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/16/2023
Locations: Research Site, Jacksonville, Florida
Conditions: Solid Tumor, NSCLC
A Study in Participants With Mild-to-moderate Systemic Lupus Erythematosus
Recruiting
The main purpose of this study is to evaluate the safety and tolerability of CUG252 following multiple ascending doses in participants with Systemic Lupus Erythematosus (SLE).
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
05/10/2023
Locations: Site 1002, Clearwater, Florida
Conditions: Systemic Lupus Erythematosus, SLE (Systemic Lupus), Autoimmune
PTSD, AUD, and Interpersonal Conflict: Within-person Associations
Recruiting
The present study seeks to increase understanding of Alcohol Use Disorder (AUD) and Posttraumatic Stress Disorder (PTSD) among veterans, an important public health concern. We will study the effects of regulatory deficits and sleep disturbance on the dynamic course of PTSD and AUD. The study will investigate whether a short, computerized training in the laboratory will alter maladaptive response biases and reduce associations between sleep disturbance, affect and behavioral dysregulation, AUD sy... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
05/08/2023
Locations: Bay Pines VA Health Care System, Bay Pines, Florida
Conditions: Stress Disorders, Post-Traumatic, Alcoholism
Development and Assessment of a Spanish-Language Hearing Loss Toolkit for Self-Management
Recruiting
The objective of this application is to develop and evaluate Spanish-language hearing education materials for adults. Our hypothesis is that participants will demonstrate better understanding of their hearing loss and associated difficulties, and will be better able to identify options for self-management following delivery of culturally and linguistically appropriate patient education materials.
Gender:
All
Ages:
50 years and above
Trial Updated:
05/08/2023
Locations: University of South Florida, Tampa, Florida
Conditions: Hearing Loss
Study 1: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients
Recruiting
Hypertension (HTN) is the single most prevalent risk factor for cardiovascular disease, diabetes, obesity and metabolic syndrome. Recent American Heart Association (AHA) statistics indicate that one-third of all adults in the United States of America suffer from HTN. Despite advances in life style modification and multi-drug therapies, 20-30% of all hypertensive patients remain resistant. These individuals exhibit autonomic dysregulation due to elevated sympathetic activity and norepinephrine s... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
05/08/2023
Locations: UF Health Cardiovascular Clinic, Gainesville, Florida
Conditions: Hypertension
A Post-market Clinical Study to Evaluate the Safety and Performance of the Carbon Fibre Reinforced Polyetheretherketone Metatarso-Phalangeal (MTP) Plate (CoLink® PCR MTP Plate) for the Treatment of Hallux Rigidus
Recruiting
The clinical study involves the routine treatment of skeletally mature patients who have been diagnosed with hallux rigidus (stiffness of the first metatarso-phalangeal joint in the foot due to arthritis and degeneration of cartilage). It follows standard practice surgery to treat this condition. This type of degenerative arthritis affects the joint of the big toe (hallux) which is attached to the foot. Taking part in this research will involve collecting data of the surgery to remove damaged c... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/03/2023
Locations: South Florida Foot and Ankle Center, Lake Worth, Florida
Conditions: Hallux Rigidus