Illinois is currently home to 2668 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Chicago, Peoria, Springfield and Urbana. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
CLEANer Aspiration for Pulmonary Embolism
NCT06189313
Recruiting
To evaluate the safety and efficacy of the Cleaner™ Pro Thrombectomy System for aspiration thrombectomy in patients with acute pulmonary embolism (PE).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: Insight Hospital and Medical Center, Chicago, Illinois
Conditions: Pulmonary Embolism, Acute Pulmonary Embolism, Cardiovascular Diseases, Venous Thromboembolism
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MADRE (Mammograms Available Due to Research and Education)
NCT05841355
Recruiting
The design builds on past studies by integrating social network analysis (SNA) and implementation science (IS) into a longitudinal randomized clinical trial (RCT). The investigator will compare the long-term effects of interventions by examining guideline-concordant initial and repeat Breast Cancer (BC) screening.
Gender:
FEMALE
Ages:
Between 40 years and 74 years
Trial Updated:
07/02/2025
Locations: Mile Square Health Center, Chicago, Illinois
Conditions: Breast Cancer Screening
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Cardiac Power Output in Cardiogenic Shock Patients
NCT05700617
Recruiting
The main purpose of this study is to determine whether differences in myocardial reserve predict clinical outcomes for heart failure patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: The University of Chicago, Chicago, Illinois
Conditions: Heart Failure, Cardiogenic Shock
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Guideline-directed Management and Therapy (GDMT) for the Prevention of Postpartum Cardiac Dysfunction in Preeclamptic African American Women
NCT05534932
Recruiting
This is a single-center, open-label pilot study looking at how Guideline-directed management and therapy (GDMP) in post-partum women with preeclampsia can improve Global Longitudinal Strain (GLS).
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
07/02/2025
Locations: University of Chicago Hospital, Chicago, Illinois
Conditions: Preeclampsia Postpartum
Register for Updates
Symptomatic Carotid Outcomes Registry
NCT05300737
Recruiting
The purpose of this study is to build upon trials done over 30 years ago, which did not include statins, new antiplatelet agents, and newer antihypertensive medications. Since the landmark trials (NASCET, ECST), there have been new developments in medical stroke prevention, which creates a gap in knowledge. The aim of this study is to evaluate that clinical care with Intensive Medical Therapy (IMT) alone, the one year stroke rate in patients with symptomatic carotid stenosis and low risk clinica... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
07/02/2025
Locations: Northwestern Memorial Hospital, Chicago, Illinois
Conditions: Carotid Stenosis, Ischemic Stroke, Transient Ischemic Attack
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Neurostimulation for the Treatment of Post-Stroke Aphasia
NCT05194566
Recruiting
The aim of the trial is to determine whether 75Hz transcranial alternating current stimulation (tACS) synchronized with therapeutic linguistic tasks is an effective form of therapy for post-stroke aphasia.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/02/2025
Locations: Think & Speak Lab at Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Post-stroke Aphasia
Register for Updates
Aspirin and Preeclampsia
NCT04479072
Recruiting
This is a single-center, double-blind, randomized, placebo-controlled clinical trial. Peripartum and postpartum Activin A are significantly elevated in women with preeclampsia. Our hypothesis is that elevated Activin A levels reflect a remediable signal and that reducing postpartum Activin A levels with aspirin therapy will improve (GLS) in preeclamptic patients.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
07/02/2025
Locations: University of Chicago Hospital, Chicago, Illinois
Conditions: Preeclampsia Postpartum
Register for Updates
Post-Surgical Stereotactic Radiotherapy (SRT) Versus GammaTile-ROADS (Radiation One and Done Study)
NCT04365374
Recruiting
This trial will be a randomized controlled study comparing the efficacy and safety of intraoperative radiation therapy using GammaTilesTM (GT) versus SRT 3-4 weeks following metastatic tumor resection which is the current standard of care.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: RUSH University, Chicago, Illinois
Conditions: Brain Metastases
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Study of Radiation Therapy Followed by Atezolizumab in Stage II or III Non-small Cell Lung Cancer Patients
NCT04310020
Recruiting
This phase II trial studies the side effects of radiation therapy followed by atezolizumab in treating patients with stage II or III non-small cell lung cancer. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more cancer cells and have fewer side effects. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to g... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: Illinois CancerCare-Bloomington, Bloomington, Illinois
Conditions: Stage II Lung Cancer AJCC v8, Stage III Lung Cancer AJCC v8, Lung Non-Small Cell Carcinoma
Register for Updates
Functional Assessment in Liver Transplantation
NCT03228290
Recruiting
This will be a prospective cohort study of patients with liver disease. Subjects will undergo geriatric assessments of frailty, functional status, and disability using functional status measures at baseline and at every clinic visit in the pre-transplant setting. Subjects will also answer questions regarding quality of life, personality, and/or cognitive function. Subjects will again undergo assessments at every clinic visit through 12 months after transplant. Then, they will be followed annuall... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: Northwestern University, Chicago, Illinois
Conditions: End Stage Liver Disease
Register for Updates
Drug Effects on Mood and Behavior - Expectancy
NCT07061886
Recruiting
This study will examine the effects of a single low dose of the 5HT2A agonist LSD (Lysergic Acid Diethylamide) (13 µg) or placebo in individuals who are or are not explicitly told what drug they will receive. Although it is known that expectancies strongly influence subjective responses to most drugs, no studies have examined expectancies on response to a very low dose of LSD. This is especially important in the context of 'microdosing' of drugs. People who practice microdosing typically do so w... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
07/01/2025
Locations: University of Chicago, Chicago, Illinois
Conditions: LSD
Register for Updates
Mood Effects of Serotonin Agonists: Depression
NCT07017478
Recruiting
This study will examine the effect of a low dose of the 5HT2A agonist LSD (26 µg), compared to placebo, on acute and protracted mood states in individuals with depression. The investigators will assess the relationship between mood-related symptoms and EEG as a neurophysiological marker.
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
07/01/2025
Locations: University of Chicago, Chicago, Illinois
Conditions: LSD, Major Depressive Disorder, Depression
Register for Updates