Illinois is currently home to 2668 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Chicago, Peoria, Springfield and Urbana. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL
NCT05211856
Recruiting
The purpose of this study is to evaluate the efficacy and safety of acalabrutinib in combination with venetoclax and acalabrutinib in combination with venetoclax with and without obinutuzumab compared to chemoimmunotherapy in subjects with previously untreated CLL.
Gender:
All
Ages:
Between 18 years and 130 years
Trial Updated:
01/14/2022
Locations: Research Site, Chicago, Illinois
Conditions: Chronic Lymphocytic Leukemia
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Glanatec(R) for Descemet Stripping in Fuch's Endothelial Dystrophy
NCT03249337
Recruiting
In brief, the objective of this study is to investigate whether the drug Glanatec ® which is approved in Japan for glaucoma and ocular hypertension, can be used in patients with Fuchs endothelial dystrophy who have had a descemet stripping procedure without endothelial keratoplasty. While some limited data exists as a proof of concept in in vitro or animal studies, and Glanatec® has been successfully used in a recently published case series for this indication, there is insufficient data to show... Read More
Gender:
ALL
Ages:
Between 18 years and 91 years
Trial Updated:
08/09/2021
Locations: NorthShore University HealthSystem, Glenview, Illinois
Conditions: Fuchs' Endothelial Dystrophy
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Pembrolizumab and Carboplatin in Treating Patients With Circulating Tumor Cells Positive Metastatic Breast Cancer
NCT03213041
Recruiting
The purpose of the study is to evaluate the impact on progression-free survival (PFS) with the combination carboplatin - pembrolizumab in patients with CTC (circulating tumor cells) positive, HER2 negative metastatic breast cancer previously treated with anthracyclines and taxanes. Previous studies have indicated that recurrent breast cancers are more resistant to chemotherapy and maybe associated with a weak immune system. This study is investigating the use of an immune therapy drug, pembroliz... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2021
Locations: Northwestern University, Chicago, Illinois
Conditions: Estrogen Receptor Negative, Estrogen Receptor Positive, HER2/Neu Negative, Progesterone Receptor Negative, Recurrent Breast Carcinoma, Stage IV Breast Cancer, Triple-Negative Breast Carcinoma
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Efficacy and Safety of Oral Rifaximin in Patients With Active Microscopic Colitis
NCT04043897
Recruiting
This is an open label study looking at rifaximin therapy for the treatment of microscopic (collagenous or lymphocytic) colitis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2021
Locations: NorthShore University HealthSystem, Evanston, Illinois
Conditions: Microscopic Colitis
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An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Ulcerative Colitis
NCT04718818
Recruiting
The present study D5272C00001 (Legacy # 3151-201-008) seeks to evaluate the efficacy and safety of brazikumab versus placebo in patients with moderately to severely active UC and will include assessments of clinical responses as demonstrated by improvement of symptoms and of colonic mucosal appearance as observed on endoscopy.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
01/19/2021
Locations: Research Site, Gurnee, Illinois
Conditions: Ulcerative Colitis
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TXA in Spine Surgery
NCT04672213
Recruiting
As tranexamic acid (TXA) becomes more prevalent, all patients are receiving the same dose and method of delivery regardless of their pre-operative risk of transfusion. Therefore, the aim of the study is to determine whether or not repeated dosing of oral or a different method of delivery like intravenous (IV) TXA reduces the post-operative reduction in hemoglobin, hematocrit, number of transfusions, and postoperative blood loss following open spine surgery.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/11/2020
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Postoperative Blood Loss Following Spine Surgery
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Proton or Photon RT for Retroperitoneal Sarcomas
NCT01659203
Recruiting
This research study is a Phase I clinical trial. Phase I clinical trials test the safety of an investigational intervention. Phase I studies also try to define the appropriate dose of the investigational therapy to use for further studies. "Investigational" means that the intervention is still being studied and that research doctors are trying to find out more about it. Retroperitoneal sarcomas are soft tissue tumors located at the far back of the abdomen. Typically, patients with retroperitone... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/01/2020
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Retroperitoneal Sarcoma
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Noninvasive Spinal Stimulation in Stroke
NCT03714282
Recruiting
This is a randomized control trial that will evaluate the effectiveness of transcutaneous (non-invasive) spinal cord stimulation on gait and balance function for individuals with hemiplegia due to stroke.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/31/2020
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Stroke
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Methadone and Quality of Postoperative Recovery
NCT03168958
Recruiting
Patients undergoing cardiac surgery often experience moderate to severe pain in the early postoperative period. A number of methods have been used to help control pain after surgery; however, each of these techniques adds additional costs and risks. A simple and effective way to decrease this pain is to administer a long-acting opioid in the operating room. Methadone is a opioid that can produce analgesia (pain relief) that lasts up to 48 hours when given in large doses (0.3 to 0.4 mg/kg). Previ... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
08/21/2020
Locations: NorthShore University HealthSystem, Evanston, Illinois
Conditions: Quality of Recovery Scores
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Clinical Trial Evaluating the Efficacy, Safety, and Tolerability of Cariprazine in a Dose-Reduction Paradigm in the Prevention of Relapse in Patients With Schizophrenia
NCT04519099
Recruiting
To evaluate the efficacy and safety of cariprazine at a target dose of 4.5 mg/d compared with placebo in prevention of relapse in patients with schizophrenia To evaluate the efficacy and safety of cariprazine at a target dose of 3.0 mg/d compared with placebo in prevention of relapse in patients with schizophrenia who were initially stabilized on a target dose of 4.5 mg/d
Gender:
All
Ages:
Between 18 years and 64 years
Trial Updated:
08/17/2020
Locations: Alexian Brothers Hospital Network, Hoffman Estates, Illinois
Conditions: Schizophrenia
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Delirium Prevention Protocol in Elderly Patients
NCT03591120
Recruiting
The current study aims to elucidate the effectiveness of a preventative delirium protocol in patients older than 65 years of age undergoing elective surgery.
Gender:
All
Ages:
Between 65 years and 89 years
Trial Updated:
07/07/2020
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Delirium
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Convalescent Plasma as a Possible Treatment for COVID-19
NCT04442191
Recruiting
Patients who are ill with COVID-19 may benefit from receiving convalescent plasma infusions containing antibodies from donors who have recovered from the disease and are proven to no longer be infected. Given the current public health emergency due to COVID-19, the FDA has recently fast-tracked the use of convalescent plasma. The purpose for this study is to assess if convalescent plasma collected from donors previously infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2),... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
06/19/2020
Locations: University of Illinois at Chicago, Chicago, Illinois
Conditions: COVID-19
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