Illinois is currently home to 2638 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Chicago, Peoria, Springfield and Urbana. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Intravesical BCG vs GEMDOCE in NMIBC
NCT05538663
Recruiting
The study hypothesis is that BCG naïve non-muscle invasive bladder cancer (NMIBC) patients treated with intravesical Gemcitabine + Docetaxel (GEMDOCE) will result in a non-inferior event-free survival (EFS) compared to standard treatment with intravesical BCG. The purpose of this study is to test whether Gemcitabine + Docetaxel is a better or worse treatment than the usual BCG therapy approach. The primary objective of this study is to determine the event free survival (EFS) of BCG-naïve high gr... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/20/2025
Locations: Saint Anthony's Health, Alton, Illinois
Conditions: Non-muscle-invasive Bladder Cancer
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Creation of a Prospective Data Collecting Registry for Genicular Artery Embolization for Arthritis
NCT06781463
Recruiting
The goal of this study is to create a prospective registry (\<100 patients) to show the effectiveness of the genicular artery embolization procedure overtime in reducing bilateral or unilateral osteoarthritic knee pain as measured by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/17/2025
Locations: University of Chicago Duchossois Center for Advanced Medicine, Chicago, Illinois
Conditions: Knee Osteoarthritis, Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA)
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Recovery Legal Care Clinical Trial
NCT06618794
Recruiting
Hospital-Based Violence Intervention Programs (HVIPs) affiliated with trauma centers in the US often focus on individual behavior modification for reduction in re-victimization. There is a lack of reproducible evidence that has demonstrated effectiveness, given the exclusion of addressing inequities in the Social and Structural Determinants of Health (SSDOH), often the root causes of violent injury and preventable homicide. The study investigators created a Medical Legal Partnership (MLP) to par... Read More
Gender:
ALL
Ages:
Between 14 years and 64 years
Trial Updated:
01/17/2025
Locations: University of Chicago Medical Center, Chicago, Illinois
Conditions: Firearm Injury, Economic Problems, Injury Traumatic, Racism, Systemic
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Development of a Culturally Tailored Resilience-building Intervention for Chinese American's Advance Care Planning Discussions
NCT06247215
Recruiting
Less than 15% of Chinese Americans complete advance directives. That is less than half of the 37% completion rate in the US general population. This disparity in the use of advance care planning between White Americans and Chinese Americans may extend to disparities in end-of-life care. To address such disparities in end-of-life care, we will develop and assess the acceptability of a culturally tailored resilience-building intervention to help Chinese Americans with cancer or heart disease and t... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
01/17/2025
Locations: University of Illinois Chicago, Chicago, Illinois
Conditions: Advance Care Planning, Neoplasms, Heart Diseases
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Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study
NCT05104983
Recruiting
This trial is a Phase II randomized, double-blind, placebo controlled multi-site study to evaluate the safety and efficacy of early sirolimus to prevent or delay seizure onset in TSC infants. This study is supported by research funding from the Office of Orphan Products Division (OOPD) of the US Food and Drug Administration (FDA).
Gender:
ALL
Ages:
Between 1 day and 6 months
Trial Updated:
01/17/2025
Locations: Lurie Children's Hospital of Chicago, Chicago, Illinois
Conditions: Tuberous Sclerosis Complex, Epilepsy
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A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Crohn's Disease (CD)
NCT04779320
Recruiting
Vedolizumab is a medicine that helps to reduce inflammation and pain in the digestive system. In this study, children and teenagers with moderate to severe Crohn's disease will be treated with vedolizumab. The main aim of the study is to check if participants achieve remission after treatment with the vedolizumab. Remission means symptoms improve or disappear and an endoscopy shows no signs of inflammation. Participants will receive 3 infusions of vedolizumab over 6 weeks. Then, those who have... Read More
Gender:
ALL
Ages:
Between 2 years and 17 years
Trial Updated:
01/17/2025
Locations: Advocate Children's Hospital Park Ridge, Park Ridge, Illinois
Conditions: Crohn's Disease (CD)
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IC-8 Apthera IOL New Enrollment Post Approval Study
NCT06060041
Recruiting
The purpose of this study is to verify the post-market safety of the IC-8 Apthera IOL after the treatment of posterior capsular opacification (PCO), an expected complication related to IC-8 Apthera IOL implantation.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
01/16/2025
Locations: Virdi Eye Clinic and Laser Vision Center, Rock Island, Illinois
Conditions: Cataract, Presbyopia, Posterior Capsule Opacification
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Outcome Comparisons of Vibratory Airway Clearance Devices
NCT05873504
Recruiting
This pilot study aims to compare the ability of a higher oscillatory index device versus a lower oscillatory index device on airway secretion clearance and other clinically significant outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/16/2025
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Airway Clearance Impairment
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ARX788 in HER2-positive, Metastatic Breast Cancer Subjects (ACE-Breast-03)
NCT04829604
Recruiting
A Global, Phase 2 Study of ARX788 in HER2-positive Metastatic Breast Cancer Patients who were previously treated with T-DXd
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/16/2025
Locations: Research Site, Chicago, Illinois
Conditions: HER2 Positive Metastatic Breast Cancer
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Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
NCT06310031
Recruiting
The goal of this study is to evaluate the safety and efficacy of the BrioVAD System by demonstrating non-inferiority to the HeartMate 3 Left Ventricular Assist System when used for the treatment of advanced, refractory, left ventricular heart failure.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
01/15/2025
Locations: University of Chicago, Chicago, Illinois
Conditions: Cardiovascular Diseases, Heart Diseases, Heart Failure
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Lymphedema Sensor Technology Development Study
NCT06778837
Recruiting
The goal of this clinical trial in adult patients diagnosed with upper extremity lymphedema is to test the safety and effectiveness of small, wearable sensors that may be able to measure lymphedema. The main questions this study aims to answer are: * Do these sensors detect lymphedema? * If so, how accurate are these wearable sensors? Participants will complete one in-person measurement session and one phone call with study staff 14 days after the measurement session to check-in on the partici... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/14/2025
Locations: Northwestern University, Chicago, Illinois
Conditions: Lymphedema Arm, Lymphedema, Cancer
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A Novel Probiotic-antibiotic Combination to Prevent Recurrent Urinary Tract Infections
NCT06149676
Recruiting
Patients with recurrent UTI were randomized to receive either the probiotic Sacchromyces Boulardii at enrollment, and the intracellularly active Ciprofloxacin with their first UTI episode after enrollment, or they received standard of care treatment.
Gender:
ALL
Ages:
Between 2 years and 17 years
Trial Updated:
01/14/2025
Locations: Lurie Children's Hospital, Chicago, Illinois
Conditions: Recurrent Uti
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