Illinois is currently home to 2672 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Chicago, Peoria, Springfield and Urbana. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Perinatal Depression and Adverse Childhood Experiences: Prevention Trial
Recruiting
The goal of this clinical trial is to evaluate the impact of ROSE in individuals with adverse childhood experiences. The main question it aims to answer is, compared to enhanced treatment as usual, does the delivery of ROSE within a collaborative care model improve depressive symptom trajectories and prevent the development of perinatal depression. Participants will be randomized to either enhanced treatment as usual or the ROSE intervention, delivered by a care manager within a perinatal colla... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/26/2025
Locations: Northwestern Medicine, Chicago, Illinois
Conditions: Perinatal Depression
Surveillance Vs. Endoscopic Therapy for Barrett's Esophagus with Low-grade Dysplasia
Recruiting
The purpose of this study is to learn the best approach to treating patients with known or suspected Barrett's esophagus by comparing endoscopic surveillance to endoscopic eradication therapy. To diagnose and manage Barrett's esophagus and low-grade dysplasia, doctors commonly use procedures called endoscopic surveillance and endoscopic eradication therapy. Endoscopic surveillance is a type of procedure where a physician will run a tube with a light and a camera on the end of it down the patien... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
02/26/2025
Locations: Northwestern Memorial Hospital, Chicago, Illinois
Conditions: Barretts Esophagus With Dysplasia, Barrett Esophagus, Esophageal Adenocarcinoma
Exactech Shoulder Post Market Clinical Follow-up Study
Recruiting
The objective of this study is to collect and evaluate long-term clinical and radiographic outcomes data in order to better understand the safety and performance of the shoulder arthroplasty over time. This study will follow subjects long-term for a minimum of 10-years, without an early-term restriction on the amount of time they will be followed.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
02/26/2025
Locations: OrthoIllinois, Rockford, Illinois
Conditions: Osteo Arthritis Shoulders, Osteonecrosis, Rotator Cuff Tears, Rotator Cuff Tear Arthropathy, Ankylosing Spondylitis, Post-traumatic Osteoarthritis, Rheumatoid Arthritis, Fracture, Infections
A Prospective Sub-Study of the Global Hypophosphatasia Registry
Recruiting
In this prospective observational sub-study, participants with pediatric-onset hypophosphatasia (HPP) (perinatal/infantile- or juvenile-onset) of any age will be followed for a minimum of 5 years at sites in the United States and potentially 1 or 2 other countries.
Gender:
ALL
Ages:
All
Trial Updated:
02/26/2025
Locations: Clinical Trial Site, Chicago, Illinois
Conditions: Hypophosphatasia
Lidocaine Infusion in Pancreatic Cancer
Recruiting
This study elucidates the effects of the intravenous (IV) lidocaine infusion on the biology of pancreatic circulating tumor cells (CTCs) isolated from patients undergoing robotic pancreatectomy for all types of pancreatic cancer. A prospective randomized controlled double blinded trial design will be used for the proposed study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/26/2025
Locations: University of Illnois at Chicago, Chicago, Illinois
Conditions: Pancreatic Cancer
Specimen and Data Study for Ovarian Cancer Early Detection and Prevention
Recruiting
RATIONALE: To improve strategies for detection and prevention of early-stage disease. PURPOSE: This research study is collecting specimens and data to develop better methods for early detection and prevention of ovarian cancer among the high risk population and those who have the disease.
Gender:
FEMALE
Ages:
Between 18 years and 80 years
Trial Updated:
02/26/2025
Locations: Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Chicago, Illinois
Conditions: Cervical Cancer, Endometrial Cancer, Fallopian Tube Cancer, Hereditary Breast/Ovarian Cancer (brca1, brca2), Ovarian Cancer, Sarcoma, Uterine Leiomyomata, Vaginal Cancer, Vulvar Cancer
Digital InteGrated Behavioral TreatmeNt for Comorbid ObesITy and DeprEssion Among Racial and Ethnic Adults Age 50 and Older
Recruiting
The goal of this randomized clinical trial is to test the efficacy of a fully digital intervention, combining the Lumen problem-solving therapy virtual coach for depression management with the Diabetes Prevention Program video-based program for weight loss, among racial and ethnic minorities with comorbid depression and obesity. The study aims include: * Determine the efficacy of the vCare intervention at 6 months. Primary outcomes are weight and depression symptom checklist 20-item (SCL-20) sc... Read More
Gender:
ALL
Ages:
Between 50 years and 74 years
Trial Updated:
02/25/2025
Locations: Department of Medicine, Vitoux Program on Aging and Prevention, Chicago, Illinois
Conditions: Obesity, Depression
Effect of Continuing Versus Holding Metformin During Hospitalizations.
Recruiting
A randomized study of continuing versus holding metformin during hospitalizations to internal medicine services to determine the effects on glucose control, acidosis, abdominal symptoms, length of stay, and mortality.
Gender:
ALL
Ages:
Between 18 years and 110 years
Trial Updated:
02/25/2025
Locations: University of Illinois at Chicago, Chicago, Illinois
Conditions: Diabetes Mellitus, Type 2
Optimizing the Floreciendo Sexual and Reproductive Health Workshop for Latina Teens and Female Caregivers: A Pilot
Recruiting
Floreciendo is a sexual and reproductive health workshop for Latina teens (ages 14-18 years) and their female caregivers (e.g., mothers, sisters, grandmothers). This study involves conducting a pilot optimization trial of Floreciendo using the multiphase optimization strategy (MOST) framework. The feasibility of using a 2 x 2 x 2 factorial trial design and the acceptability of the intervention components of Floreciendo will be examined. Effectiveness and implementation outcomes will be explored.... Read More
Gender:
ALL
Ages:
14 years and above
Trial Updated:
02/25/2025
Locations: Gads Hill Center, Chicago, Illinois
Conditions: Sexual Risk Behavior, Sexually Transmitted Infections, Unplanned Pregnancy
The Gut Microbiome and Serum Metabolites As a Biological Mechanism Underlying Pain in Kidney Transplantation
Recruiting
Study Summary Nearly half (47%) of people with end-stage kidney disease (ESKD) whose kidney function is restored after kidney transplantation experience chronic pain compared to 19% of adults in the US general population. Pain is associated with comorbid fatigue, depression and anxiety, and withdrawal from usual physical and social activities; resulting in an inability to participate in and enjoy life. Severe pain can result in nonadherence to immunosuppression and treatment protocols and result... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: UI Health, Chicago, Illinois
Conditions: Kidney Transplant Symptoms, Gut Microbiome
Facilitating Advance Care Planning Discussions for People With Advance Cancer
Recruiting
The aims of this study are to (1) identify the advance care planning deliberation process among 20 dyads of patients with advanced cancer and family caregivers and (2) conduct usability testing among 9 dyads to refine the content and design of the web-based resilience-building intervention.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/25/2025
Locations: University of Illinois Chicago, Chicago, Illinois
Conditions: Resilience, Psychological, Advance Care Planning
uTRACT Jelmyto Registry: A Registry of Patients With Upper Tract Urothelial Cancer (UTUC) Treated With Jelmyto
Recruiting
The purpose of this registry is to evaluate real world experience and outcomes of patients with Upper Tract Urothelial Cancer (UTUC) treated with Jelmyto in the United States.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: Northwestern University, Chicago, Illinois
Conditions: Urothelial Carcinoma, Urothelial Carcinoma Recurrent, Urothelial Carcinoma Ureter, Urothelial Carcinoma Ureter Recurrent, Urothelial Cancer of Renal Pelvis, Urothelial Carcinoma of the Renal Pelvis and Ureter, Carcinoma, Transitional Cell, Transitional Cell Carcinoma of Renal Pelvis