Illinois is currently home to 2681 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Chicago, Peoria, Springfield and Urbana. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy
NCT03487185
Recruiting
A randomized controlled trial of 1,500 women to assess whether treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP) in pregnancy will result in a reduction in the rate of hypertensive disorders of pregnancy.
Gender:
Female
Ages:
18 years and above
Trial Updated:
06/17/2024
Locations: Northwestern University, Chicago, Illinois
Conditions: Obstructive Sleep Apnea of Adult, Preeclampsia, Obstetrical Complications
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Effects of MK-3475 (Pembrolizumab) on the Breast Tumor Microenvironment in Triple Negative Breast Cancer
NCT02977468
Recruiting
Assess response to pembrolizumab in both primary tumor, normal breast stroma, circulating lymphocytes and serum exosomes in treatment naive triple negative breast cancer (TNBC) patients. Assess for change in tumor-infiltrating lymphocytes (TILS) both stromal (sTILS) and intraepithelial (iTILS) in newly diagnosed early stage TNBC patients treated with two doses of MK-3475 prior to lumpectomy.
Gender:
Female
Ages:
Between 21 years and 80 years
Trial Updated:
06/17/2024
Locations: Loyola University Chicago, Maywood, Illinois
Conditions: Triple Negative Breast Cancer
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A Study of Valemetostat Tosylate in Combination With DXd ADCs in Subjects With Solid Tumors
NCT06244485
Recruiting
This study will evaluate the safety, tolerability, and efficacy of valemetostat tosylate in combination with DXd ADC in patients with advanced solid tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/14/2024
Locations: University of Chicago Medical Center, Chicago, Illinois
Conditions: Advanced Solid Tumor
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Studying Malnutrition And Sarcopenia In Older Adults With Acute Myeloid Leukemia
NCT05458258
Recruiting
This study will explore how malnutrition (poor nutrition/diet) and sarcopenia (a condition that causes a loss of muscle and bone mass) affects study participants over the age of 60 with acute myeloid leukemia (AML) who will receive induction chemotherapy (chemotherapy given as the first treatment to help cancer go into remission) and/or cancer drugs as part of standard care for AML. By studying how these nutritional and skeletal factors, doctors leading this study hope to learn how malnutrition... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
06/14/2024
Locations: University of Chicago Medicine Comprehensive Cancer Center, Chicago, Illinois
Conditions: Acute Myeloid Leukemia, Leukemia, Myeloid
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Abbott Vascular Medical Device Registry
NCT04573660
Recruiting
The AV-MDR is a prospective, non-randomized, open-label, multi-center registry. The purpose of the AV-MDR study is to proactively collect and evaluate clinical data on the usage of the devices in scope within their intended use with the aim of confirming safety and performance throughout their expected lifetime, ensuring the continued acceptability of identified risks, detecting emerging risks on the basis of factual evidence, ensuring the continued acceptability of the benefit-risk ratio, and i... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/14/2024
Locations: Northwestern Memorial Hospital, Chicago, Illinois
Conditions: Acute Myocardial Infarction, Restenoses, Coronary, Coronary Artery Lesions, Venous Embolism, Arterial Embolism
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Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
NCT04262206
Recruiting
PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in community-dwelling older adults without cardiovascular disease (CVD) or dementia will demonstrate the benefit of statins for reducing the primary composite of death, dementia, and persistent disability and secondary composites including mild cognitive impairment (MCI) and cardiovascular events.
Gender:
All
Ages:
75 years and above
Trial Updated:
06/14/2024
Locations: Northwestern University, Chicago, Illinois
Conditions: Cognitive Impairment, Mild, Dementia, Cardiovascular Diseases
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Robotic-Assisted da Vinci System Prophylactic Nipple-Sparing Mastectomy
NCT03892980
Recruiting
This study evaluates the safety and effectiveness of the da Vinci Surgical Systems in prophylactic Nipple Sparing Mastectomy procedures.
Gender:
Female
Ages:
Between 18 years and 80 years
Trial Updated:
06/14/2024
Locations: NorthShore University Health System, Evanston, Illinois
Conditions: Nipple Sparing Mastectomy
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Study to Determine if Patients Exposed to General Anesthesia Significant Numbers of Times Would Increase the Risk for Intraoperative Awareness.
NCT05857618
Recruiting
This study will detect whether prior exposure to general anesthesia multiple times is associated with an increased incidence of awareness with explicit recall (AWR). This is especially important because patients who need to undergo multiple events of general anesthesia are medically some of the most vulnerable populations. The study hypothesizes that patients with significant exposure to general anesthesia have a higher incidence of AWR. This study may help clinicians and patients to better unde... Read More
Gender:
All
Ages:
7 years and above
Trial Updated:
06/13/2024
Locations: University of Chicago Medical Center, Chicago, Illinois
Conditions: Intraoperative Awareness, General Anesthesia
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VNS-REHAB At-Home - Post-Market Study for Using the Vivistim System® at Home
NCT05691023
Recruiting
This is a single-arm post-market study of up to 150 participants, using up to 50 mobile therapists to conduct up to 36-hours at-home therapy. The study will assess at-home therapy implementation instead of an in-clinic therapy implementation for patients who are commercially implanted with the Vivistim System. Patients will be consented for eligibility if appropriate to be implanted with the Vivistim System per the indications for use (The MicroTransponder® Vivistim® Paired VNS™ System is intend... Read More
Gender:
All
Ages:
19 years and above
Trial Updated:
06/13/2024
Locations: Moxie OT, Chicago, Illinois
Conditions: Ischemic Stroke, Upper Extremity Problem
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Guideline-directed Management and Therapy (GDMT) for the Prevention of Postpartum Cardiac Dysfunction in Preeclamptic African American Women
NCT05534932
Recruiting
This is a single-center, open-label pilot study looking at how Guideline-directed management and therapy (GDMP) in post-partum women with preeclampsia can improve Global Longitudinal Strain (GLS).
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
06/13/2024
Locations: University of Chicago Hospital, Chicago, Illinois
Conditions: Preeclampsia Postpartum
Register for Updates
Diabetic Neuropathy in Spinal Cord Stimulator Patients
NCT04687215
Recruiting
The objective of this study is to assess the effect Spinal Cord Stimulators have toward improving vascular changes of diabetes mellitus in patients eligible for SCS placement based on their condition of painful diabetic neuropathy; we will evaluate improving their disability and quality of life, improving micro-circulatory changes induced by Diabetes Mellitus (DM), improving macro-circulatory changes induced by DM and improving arterial stiffness of the vessels of the lower extremity.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/13/2024
Locations: University of Chicago Medical Center, Chicago, Illinois
Conditions: Diabetes Mellitus, Neuropathy, Neuropathic Pain, Vascular Diseases, Vascular Stiffness, Microvascular Changes, Pain, Chronic
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Aspirin and Preeclampsia
NCT04479072
Recruiting
This is a single-center, double-blind, randomized, placebo-controlled clinical trial. Peripartum and postpartum Activin A are significantly elevated in women with preeclampsia. Our hypothesis is that elevated Activin A levels reflect a remediable signal and that reducing postpartum Activin A levels with aspirin therapy will improve (GLS) in preeclamptic patients.
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
06/13/2024
Locations: University of Chicago Hospital, Chicago, Illinois
Conditions: Preeclampsia Postpartum
Register for Updates