Illinois is currently home to 2670 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Chicago, Peoria, Springfield and Urbana. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Accurate, Rapid and Inexpensive MRI Protocol for Breast Cancer Screening
NCT04877912
Recruiting
The purpose of this study is to test an innovative MRI breast cancer screening method in women with mammographically dense breasts as well as other women with moderately increased cancer risk. MRI, combined with other methods of risk assessment, has potential to significantly improve sensitivity to cancer in dense breasts and detect cancer in all cases at a much earlier stage, with far fewer interval cancers than mammography. Previous tests of MRI sensitivity show that this screening could signi... Read More
Gender:
Female
Ages:
Between 40 years and 74 years
Trial Updated:
05/04/2021
Locations: University of Chicago Mitchell Hospital, Chicago, Illinois
Conditions: Breast Cancer
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Pembrolizumab and Carboplatin in Treating Patients With Circulating Tumor Cells Positive Metastatic Breast Cancer
NCT03213041
Recruiting
The purpose of the study is to evaluate the impact on progression-free survival (PFS) with the combination carboplatin - pembrolizumab in patients with CTC (circulating tumor cells) positive, HER2 negative metastatic breast cancer previously treated with anthracyclines and taxanes. Previous studies have indicated that recurrent breast cancers are more resistant to chemotherapy and maybe associated with a weak immune system. This study is investigating the use of an immune therapy drug, pembroliz... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/30/2021
Locations: Northwestern University, Chicago, Illinois
Conditions: Estrogen Receptor Negative, Estrogen Receptor Positive, HER2/Neu Negative, Progesterone Receptor Negative, Recurrent Breast Carcinoma, Stage IV Breast Cancer, Triple-Negative Breast Carcinoma
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Collecting Tissue Samples for Future Research From Women Undergoing Surgery for Breast Cancer
NCT00898131
Recruiting
RATIONALE: Collecting and storing samples of tumor tissue from patients with breast cancer to study in the laboratory may help doctors learn more about cancer. PURPOSE: This phase I study is collecting tissue samples for future research from women undergoing surgery for breast cancer.
Gender:
Female
Ages:
All
Trial Updated:
04/30/2021
Locations: Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Chicago, Illinois
Conditions: Breast Cancer
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Illinois United ePREP Program Evaluation
NCT04378309
Recruiting
The current research is designed to implement and evaluate the ePREP relationship intervention with couples throughout the state of Illinois.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/29/2021
Locations: University of Illinois Extension, Urbana, Illinois
Conditions: Relationship, Marital, Relational Problems
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Study Investigating the Efficacy of Crenolanib With Chemotherapy vs Chemotherapy Alone in R/R FLT3 Mutated AML
NCT03250338
Recruiting
This is a randomized, multi-center, double-blind, placebo-controlled study designed to evaluate the efficacy of crenolanib administered following salvage chemotherapy, consolidation chemotherapy, post bone marrow transplantation and as maintenance in relapsed/refractory AML subjects with FLT3 activating mutation.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
04/28/2021
Locations: University of Chicago, Chicago, Illinois
Conditions: Relapsed/Refractory Acute Myeloid Leukemia With FLT3 Activating Mutations
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Efficacy and Safety of Oral Rifaximin in Patients With Active Microscopic Colitis
NCT04043897
Recruiting
This is an open label study looking at rifaximin therapy for the treatment of microscopic (collagenous or lymphocytic) colitis.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/14/2021
Locations: NorthShore University HealthSystem, Evanston, Illinois
Conditions: Microscopic Colitis
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Effects of Lutein Supplementation on Cognition and MPOD in Multiple Sclerosis Patients-
NCT04843813
Recruiting
The central hypothesis is that lutein supplementation will improve MPOD and cognition. Accordingly, the specific aims are to 1) to determine the process feasibility associated with participating in 4-month lutein supplementation trial; and 2) to investigate the scientific feasibility of 4-month daily lutein supplementation on biological markers of lutein status and cognitive function among persons with MS.
Gender:
All
Ages:
Between 18 years and 64 years
Trial Updated:
04/12/2021
Locations: University of Illinois at Urbana-Champaign, Urbana, Illinois
Conditions: Multiple Sclerosis
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An Amniotic Membrane Injection Comparing Two Doses (1 mL and 2 mL Injection) and a Placebo (Sterile Saline) in the Treatment of Osteoarthritis of the Knee
NCT04612023
Recruiting
The purpose of this study is to determine the dose effect of a single injectable acellular amniotic membrane derived allograft for the treatment of knee osteoarthritis and to confirm whether the use of 2 mL of the same amniotic injection offers a statistically significant advantage over the 1 mL injection when compared to a placebo.
Gender:
All
Ages:
Between 21 years and 80 years
Trial Updated:
02/10/2021
Locations: ICORE, Westmont, Illinois
Conditions: Osteoarthritis, Knee
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Positive Pressure Treadmill Walking for Individuals With Knee Pathology
NCT04747444
Recruiting
Our goal is to compare the serum biomarker changes of joint disease that occur in response to partially off-loaded (50%) walking exercise to regular (100%) walking exercise while on a Lower Body Positive Pressure (LBPP) treadmill. Secondly we are determining the relationship between changes in the concentration of these serum biomarkers and participant reported knee pain while walking on a LBPP treadmill.
Gender:
All
Ages:
50 years and above
Trial Updated:
02/06/2021
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Knee Osteoarthritis
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Evaluating Wearable Smart Sensors for Continuous Measurement of Vital Signs in ICU Patients
NCT04723654
Recruiting
The purpose of this study is to develop biocompatible wireless electronic devices that will allow continuous, non-invasive hemodynamic and physiology measurements in the ICU.
Gender:
All
Ages:
18 years and below
Trial Updated:
01/20/2021
Locations: Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois
Conditions: Prematurity
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An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Ulcerative Colitis
NCT04718818
Recruiting
The present study D5272C00001 (Legacy # 3151-201-008) seeks to evaluate the efficacy and safety of brazikumab versus placebo in patients with moderately to severely active UC and will include assessments of clinical responses as demonstrated by improvement of symptoms and of colonic mucosal appearance as observed on endoscopy.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
01/19/2021
Locations: Research Site, Gurnee, Illinois
Conditions: Ulcerative Colitis
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Testing an Active Form of Tamoxifen (4-hydroxytamoxifen) Delivered Through the Breast Skin to Control Ductal Carcinoma in Situ (DCIS) of the Breast
NCT02993159
Recruiting
This randomized phase IIB trial studies how well tamoxifen or afimoxifene works in treating patients with estrogen receptor positive breast cancer. Estrogen can cause the growth of breast cancer cells. Hormone therapy using tamoxifen citrate or afimoxifene may fight breast cancer by blocking the use of estrogen by the tumor cells.
Gender:
Female
Ages:
18 years and above
Trial Updated:
12/17/2020
Locations: Northwestern University, Chicago, Illinois
Conditions: Ductal Breast Carcinoma In Situ, Estrogen Receptor Positive
Register for Updates