Illinois is currently home to 2668 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Chicago, Peoria, Springfield and Urbana. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study to See Iftolvaptan is Safe in Infants and Children Who at Enrollment Are 28 Days to Less Than 18 Years Old withAutosomal Recessive Polycystic Kidney Disease (ARPKD)
NCT04782258
Recruiting
To evaluate the safety of tolvaptan in pediatric subjects with ARPKD
Gender:
ALL
Ages:
Between 28 days and 18 years
Trial Updated:
08/05/2025
Locations: Northwestern University Feinberg School of Medicine - Ann & Robert H. Lurie Children's Hospital of Chicago - Neonatology, Chicago, Illinois
Conditions: Autosomal Recessive Polycystic Kidney (ARPKD)
Register for Updates
Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors
NCT04665206
Recruiting
This is an open-label, dose escalation and expansion study to evaluate the safety, tolerability, PK, and biological activity of VT3989 administered, alone or in combination, once daily in patients with mesothelioma and/or metastatic solid tumors that are resistant to standard therapy or for which no effective standard therapy is available.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/05/2025
Locations: University of Chicago Medical Center, Chicago, Illinois
Conditions: Solid Tumor, Adult, Mesothelioma, NSCLC
Register for Updates
Testing the Addition of the Anti-cancer Drug, Tazemetostat, to the Usual Treatment (Dabrafenib and Trametinib) for Metastatic Melanoma That Has Progressed on the Usual Treatment
NCT04557956
Recruiting
This phase I/II trial investigates the best dose, possible benefits and/or side effects of tazemetostat in combination with dabrafenib and trametinib in treating patients with melanoma that has a specific mutation in the BRAF gene (BRAFV600) and that has spread from where it first started (primary site) to other places in the body (metastatic). Tazemetostat, dabrafenib, and trametinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving tazemetostat i... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/05/2025
Locations: Northwestern University, Chicago, Illinois
Conditions: Clinical Stage IV Cutaneous Melanoma AJCC v8, Metastatic Melanoma
Register for Updates
Hip Arthroscopy Postoperative Opioid Demands
NCT04094701
Recruiting
This study will be a prospective, single-blinded, randomized controlled trial (RCT), investigating the influence of the number of opioid pills prescribed following primary hip arthroscopy. All patients who sign the consent form will be enrolled in the suited and randomized to one of the two treatment arms. The intervention group will receive 5 Norco pills, gabapentin (30 mg, once daily for 10 days following surgery), and Tylenol (1000 mg, three times daily for 10 days following surgery) while th... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/05/2025
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Opioid Use, Pain, Femoral Acetabular Impingement, Labral Tear, Glenoid
Register for Updates
Citadel Embolization Device Study
NCT04057352
Recruiting
The purpose of this study is to gather safety and effectiveness data on Stryker Neurovascular's Next Generation Target Detachable Coil (hereafter referred to as the Citadel Embolization Device), when used with Target Detachable Coils, in the treatment of wide-neck intracranial aneurysms.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/05/2025
Locations: Northwestern University, Chicago, Illinois
Conditions: Unruptured Wide-neck Aneurysms
Register for Updates
Protocol for Collecting, Banking and Distributing Human Tissue Samples: St. Jude Children's Research Hospital Tissue Resources Core Facility
NCT01354002
Recruiting
The aims of this protocol are: to collect and store diseased and normal tissue and body fluid samples from new and returning patients at St. Jude Children's Research Hospital (SJCRH), affiliated sites and collaborating institutions; to collect and store samples from relatives of SJCRH patients; to collect and store retrospective and prospective pertinent corresponding clinical and laboratory data on disease characterization, treatment, and outcome; and to serve as a source of human biological sa... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/05/2025
Locations: Children's Hospital of Illinois at OSF-Saint Francis Medical Center, Peoria, Illinois
Conditions: Normal and Diseased Tissue and Body Fluids Samples
Register for Updates
A Phase 2 Study to Evaluate Therapies for Inflammatory Bowel Disease
NCT07113522
Recruiting
This is a Phase 2, multicenter, platform study in adult participants with IBD (moderately to severely active Crohn's Disease or Ulcerative Colitis). The primary goal of this study is to assess the safety and efficacy of multiple investigational drugs.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/04/2025
Locations: Mirador Therapeutics Selected Site, Glenview, Illinois
Conditions: Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC), Crohn's Disease
Register for Updates
Inspire UAS High Apnea Hypopnea Index (AHI)/High Body Mass Index (BMI) Post-Approval Study
NCT07113288
Recruiting
The purpose of this observational clinical study is to provide evaluation of long-term safety and effectiveness in a newly expanded patient population including patients with a higher AHI and a higher BMI.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/04/2025
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Obstructive Sleep Apnea (OSA)
Register for Updates
A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Inpatient Adults With Schizophrenia
NCT07038876
Recruiting
ML-007C-MA-211 is a Phase 2, randomized, double-blind, placebo-controlled study to evaluate the efficacy, safety, and tolerability of orally administered ML-007C-MA in inpatient adult participants aged 18 to 64 years with schizophrenia experiencing an acute exacerbation of psychosis. The primary objective is to evaluate the efficacy of ML-007C-MA compared with placebo in the treatment of subjects with inadequately controlled symptoms of schizophrenia as measured by the Positive and Negative Syn... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
08/04/2025
Locations: Clinical Site, Chicago, Illinois
Conditions: Schizophrenia
Register for Updates
Partnering With Antenatal Navigators to Transform Health in Pregnancy
NCT06941974
Recruiting
The Partnering with Antenatal Navigators to Transform Health in Pregnancy (PATH) study aims to evaluate whether an antenatal patient navigation program improves maternal health, neonatal health, pregnant women's experiences, and health care utilization outcomes among low-income pregnant women and their neonates. Patient navigation is an individualized, barrier-focused, longitudinal, patient-centered intervention that offers support for a defined set of health services. In this randomized control... Read More
Gender:
FEMALE
Ages:
Between 16 years and 50 years
Trial Updated:
08/04/2025
Locations: Northwestern Memorial Hospital, Chicago, Illinois
Conditions: Maternal Morbidity, Antenatal Health, Neonatal Morbidity, Retention in Care, Prenatal Care
Register for Updates
The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial
NCT06871111
Recruiting
The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) trial is a single center prospective adaptive phase 1b clinical trial in patients who are hospitalized with complications of liver disease and have low fecal metabolite levels (butyrate and deoxycholic acid). The study intervention is 1 of 9 novel live Commensal Consortia each containing eight commensal bacterial strains derived from healthy donors. The primary objective of the study is to determine safety and tolerability of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/04/2025
Locations: The University of Chicago Medical Center, Chicago, Illinois
Conditions: Liver Diseases, Liver Failure, Cirrhosis, Liver
Register for Updates
NSAID Use for Treating Dysmenorrhea and Preventing Chronic Pelvic Pain (NSAID HEAL)
NCT06861920
Recruiting
The goal of this clinical trial is to learn if NSAIDs (i.e. naproxen sodium) can treat menstrual pain and prevent the development of chronic pelvic pain in menstruating adults with painful periods. The main questions it aims to answer are: * Can non-menstrual pelvic pain reduction be predicted by menstrual pain response to NSAIDs? * Will participants with the largest reductions in multi-site sensitivity following NSAID therapy have the largest reductions in non-menstrual pelvic pain? Researche... Read More
Gender:
FEMALE
Ages:
Between 18 years and 35 years
Trial Updated:
08/04/2025
Locations: Endeavor Health, Evanston, Illinois
Conditions: Dysmenorrhea, Chronic Pelvic Pain, Pelvic Pain
Register for Updates