Colorado is currently home to 1808 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Denver, Aurora, Colorado Springs and Englewood. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Optimizing Pulsatility During Cardiopulmonary Bypass
NCT05344573
Recruiting
Cardiopulmonary bypass during cardiac surgery provides blood flow to the body during surgery but has adverse effects on different organs. Blood flow during cardiopulmonary bypass may be pulsatile or non-pulsatile, which may impact normal organ function after surgery. The study will collect data on the type of cardiopulmonary bypass used during surgery and organ function to determine if there is an association between the type of bypass and organ function.
Gender:
ALL
Ages:
Between 50 years and 70 years
Trial Updated:
11/18/2024
Locations: University of Colorado Hospital, Aurora, Colorado
Conditions: Endothelial Dysfunction, Acute Kidney Injury
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Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study
NCT03808922
Recruiting
This study will seek to enroll immunocompromised patients with Lower Tract parainfluenza infection. It also contains a sub-study to enroll patients with severe COVID-19.
Gender:
ALL
Ages:
All
Trial Updated:
11/18/2024
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Lower Respiratory Tract Infection, Parainfluenza, Immunocompromised, COVID-19
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Fresh Autologous Whole Blood Transfusion After Cardiopulmonary Bypass
NCT03204357
Recruiting
Autologous blood transfused at the end of cardiopulmonary bypass will reduce total blood loss 24 hours after surgery and improve mitochondrial oxygen delivery measured by plasma succinate levels. The study design is a prospective randomized interventional trial of transfusion of fresh autologous whole blood versus standard of care expectant management of bleeding during elective cardiac surgery.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
11/18/2024
Locations: University of Colorado Hospital, Aurora, Colorado
Conditions: Cardiac Disease, Bleeding Postoperative
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Innovations in Hearing Accessibility and Technology (IHAT) Study
NCT06689865
Recruiting
The research will explore outcomes of different service delivery models of over-the-counter (OTC) hearing aids by comparing them to prescription hearing aids fitted by specialists in individuals with mild to moderate hearing loss. The investigators will examine how each type affects users' experiences, behavior, thinking skills, and brain activity related to hearing. Additionally, the study will focus on what types of people prefer each hearing aid option, what helps or hinders these choices, an... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
11/15/2024
Locations: University of Colorado School of Medicine, Aurora, Colorado
Conditions: Hearing Loss, Hearing Aids, OTC Hearing Aids
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Patient Preferences for Barrett's Esophagus and Esophageal Cancer Screening Tests
NCT06693622
Recruiting
This study plans to learn more about what patients think about screening for esophageal cancer (EAC) and Barrett's esophagus (BE); a pre-cancerous condition associated with esophageal cancer. The plan is to use this information to modify screening practices in the United States with the goal to decrease the number of people who die from esophageal cancer.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
11/14/2024
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Gastro Esophageal Reflux Disease, Barrett Esophagus
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Corticosteroids for Post-Extubation Dysphagia
NCT06670521
Recruiting
This is a placebo-controlled, double-blind randomized trial of a short course of intravenous corticosteroids for Acute Respiratory Failure Survivors with Fiberoptic Endoscopic Evaluation of Swallowing (FEES) documented laryngeal edema. Study was leveraged using the existing R01 grant infrastructure COMIRB # 21-3873, study design, and research methods. Patients for the study proposed will have already been enrolled in the R01 longitudinal cohort study. The sites to perform this study include Colo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/14/2024
Locations: University of Colorado, Aurora, Colorado
Conditions: Dysphagia, Laryngeal Edema
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Testing an Accelerated TMS Protocol for Methamphetamine Use Disorder
NCT06320366
Recruiting
The investigators will evaluate the effects of an accelerated Transcranial Magnetic Stimulation (TMS) protocol of the left dorsolateral prefrontal cortex (DLPFC) for moderate to severe methamphetamine use disorder. This is a randomized parallel group design to assess feasibility and safety, evaluate efficacy (use, craving) and identify magnetic resonance imaging (resting state and cue craving) associated with group/outcomes.
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
11/14/2024
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Methamphetamine Use Disorder
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Evaluating the Effects of Tasimelteon Vs. Placebo in Delayed Sleep-Wake Phase Disorder (DSWPD)
NCT04652882
Recruiting
This is a multicenter, double-blind, randomized study to evaluate the efficacy and safety of a daily single oral dose of tasimelteon and matching placebo in male and female participants with DSWPD.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
11/14/2024
Locations: Vanda Investigational Site, Aurora, Colorado
Conditions: Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm, Chronobiology Disorders
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Dead Space and Inhaled Nitric Oxide in Pediatric Acute Respiratory Distress Syndrome
NCT06690801
Recruiting
The goal of this observational study is to determine whether a marker of dead space (the end-tidal to alveolar dead space fraction \[AVDSf\]) is more strongly associated with mortality risk than markers of oxygenation abnormality (oxygenation index) and to determine whether dead space (AVDSf) is an important marker of heterogeneity in the inhaled nitric oxide (iNO) treatment effect for children with acute respiratory distress syndrome (ARDS). The study aims are: 1. To validate AVDSf for risk s... Read More
Gender:
ALL
Ages:
Between 0 years and 21 years
Trial Updated:
11/13/2024
Locations: Children's Hospital Colorado, Denver, Colorado
Conditions: Acute Respiratory Distress Syndrome
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Oral Contraceptive Pill (OCP) Pharmacogenomics
NCT06334315
Recruiting
The goal of this clinical trial is to evaluate how differences in specific parts of our DNA can influence how individual bodies break down the hormones contained within oral contraceptive pills, which could affect how well these birth control pills work to prevent pregnancy. The investigators are also interested in exploring how these differences in our DNA can also explain why patients taking the exact same formulation of birth control pill will experience very different side effects. The main... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
11/13/2024
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Contraception, Pharmacogenomic Drug Interaction
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Study of DISC-0974 to Assess the Safety, Tolerability, PK and PD of DISC-0974 in Participants with CKD and Anemia
NCT05745883
Recruiting
This Phase 1b study of DISC-0974 will assess the safety, tolerability, pharmacokinetics (PK) and Pharmacodynamics (PD) of DISC-0974 in adult participants with Non-Dialysis Dependent Chronic Kidney Disease and Anemia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: Rocky Mountain Kidney Care - Lone Tree, Lone Tree, Colorado
Conditions: Chronic Kidney Diseases, Anemia of Chronic Kidney Disease
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Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067
NCT04787042
Recruiting
This is a multiphase, multicenter study, which includes a Phase 1a open-label, dose escalation monotherapy study of ST-067 given as an SC injection with or without obinutuzumab \[Gazyva®\] pre-treatment, by IV infusion, and in combination with pembrolizumab. A Phase 2 monotherapy arm is also planned; the exact design of the Phase 2 study elements with respect to formulation and pre-treatment will be determined after completion of the Phase 1 study portion of the trial.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: Sarah Cannon Research Institute at HealthONE, Denver, Colorado
Conditions: Cancer, Solid Tumor, Melanoma, Renal Cell Carcinoma, Triple-negative Breast Cancer, Non Small Cell Lung Cancer, Squamous Cell Carcinoma of the Head and Neck, Carcinoma, MSI-High
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