Colorado is currently home to 1805 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Denver, Aurora, Colorado Springs and Englewood. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Convergent Mechanisms Underlying Reprometabolic Syndrome in Women
NCT06686537
Recruiting
Dr. Nanette Santoro proposes to test the specific question that obesity results in abnormal estradiol response at the level of the pituitary and hypothalamus. This will be shown in diminished pituitary sensitivity to gonadorelin releasing hormone with a reduced estradiol induced luteinizing hormone surge in obese women.
Gender:
FEMALE
Ages:
Between 18 years and 38 years
Trial Updated:
04/30/2025
Locations: University of Colorado School of Medicine, Aurora, Colorado
Conditions: Infertility, Female, Obesity
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Study of ISM3412 in Participants With Locally Advanced/Metastatic Solid Tumors
NCT06414460
Recruiting
The study has consists of two parts, a dose escalation part (Part 1) and a dose selection optimization part (Part 2). The primary objectives of this study are to evaluate the safety and tolerability of ISM3412 in participants with locally advanced/metastatic solid tumors, and to determine the RP2D of ISM3412.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2025
Locations: Sarah Cannon Research Institute at HealthONE, Denver, Colorado
Conditions: Locally Advanced/Metastatic Solid Tumors
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An Observational Study Comparing Delandistrogene Moxeparvovec With Standard of Care in Participants With Duchenne Muscular Dystrophy
NCT06270719
Recruiting
This is a multicenter, prospective, observational Phase 4 study in the United States. The study is designed to collect both medical history and prospective data on Duchenne muscular dystrophy (DMD) treatment outcomes in participants receiving delandistrogene moxeparvovec as part of clinical care, compared to participants with DMD receiving or prescribed to start chronic glucocorticoid treatment at baseline in routine clinical practice.
Gender:
MALE
Ages:
4 years and above
Trial Updated:
04/30/2025
Locations: University of Colorado - PPDS, Aurora, Colorado
Conditions: Duchenne Muscular Dystrophy
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Open-Label Umbrella Study To Evaluate Safety And Efficacy Of Elacestrant In Various Combination In Patients With Metastatic Breast Cancer
NCT05563220
Recruiting
This is a multicenter, Phase 1b/2 trial. The phase 1b part of the trial aims to determine the RP2D of elacestrant when administered in combination with alpelisib, everolimus, palbociclib, abemaciclib, and ribociclib. The Phase 2 part of the trial will evaluate the efficacy and safety of the various combinations in patients with ER+/HER2- advanced/metastatic breast cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2025
Locations: Rocky Mountain Cancer Centers, Lone Tree, Colorado
Conditions: Breast Cancer, Metastatic Breast Cancer
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The Pediatric Lupus Nephritis Mycophenolate Mofetil (PLUMM) Study
NCT05538208
Recruiting
The study is a 1-year 2-part double-blinded placebo controlled 2-arm clinical trial. Treatment arms are (1) MMF dosed as per body-surface area (MMFBSA; 600mg/m2 body surface area per dose about every 12 hours) and (2) pharmacokinetically-guided precision-dosing of MMF (MMFPK; MMF dosed twice daily to achieve an area under the concentration-time curve (AUC0-12h) of MPA \>60-70 mg\*h/L. The study goal is to determine the safety and efficacy of MMFPK compared to MMFBSA for the treatment of prolifer... Read More
Gender:
ALL
Ages:
Between 8 years and 20 years
Trial Updated:
04/30/2025
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Lupus Nephritis
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Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients, CORAL Study
NCT05410977
Recruiting
This study collects blood and stool samples from patients with suspected or diagnosed Lynch syndrome to evaluate a deoxyribonucleic acid (DNA) screening technique for the detection of colorectal cancer in Lynch syndrome patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2025
Locations: University of Colorado Anschutz Medical Center, Aurora, Colorado
Conditions: Colorectal Carcinoma, Lynch Syndrome
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An Observational Research Study for Cancer Patients on Immune Checkpoint Inhibitors, DiRECT Study
NCT05364086
Recruiting
This study compares treatment outcomes between patients of African American/Black (AA) ancestry and European American/White (EA) ancestry currently receiving immune checkpoint inhibitor treatment. Collecting samples of blood and saliva and health and treatment information from racially diverse patients receiving immune checkpoint inhibitor treatment over time may help doctors better understand health care disparities among all cancer patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2025
Locations: Kaiser Permanente-Franklin, Denver, Colorado
Conditions: Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
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Bupropion to Reduce Cancer Related Fatigue in Cancer Survivors
NCT03996265
Recruiting
This phase III trial studies how well bupropion works in reducing cancer related fatigue in cancer survivors. Cancer and its treatment can cause fatigue. Bupropion is a drug that is used to treat depression, as well as to help people quit smoking. It belongs to the family of drugs called antidepressants and works by increasing certain types of activity in the brain. Bupropion may reduce cancer-related fatigue by causing changes in inflammation and stress hormones.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2025
Locations: Rocky Mountain Cancer Centers-Aurora, Aurora, Colorado
Conditions: Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
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Health Without Barriers/Salud Sin Barreras- Northern Colorado
NCT06822387
Recruiting
The overarching goal of this work is to address the limited access to evidence-based health behavior and lifestyle interventions for youth and families most impacted by preventable chronic diseases, including obesity and type 2 diabetes. In the current project, we implement a small single-arm pilot and feasibility trial of Health Without Barriers/Salud Sin Barreras (HWB/SSB), a culturally-adapted, whole-family intensive health behavior and lifestyle intervention to 11-19-year-old adolescents and... Read More
Gender:
ALL
Ages:
11 years and above
Trial Updated:
04/29/2025
Locations: Colorado State University, Fort Collins, Colorado
Conditions: Lifestyle Risk Reduction, Adolescent Health, Family Health, Cardio-metabolic Health, Mental Health, Wellness Program, Type 2 Diabetes, Obesity, Adolescent
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Effect of Omalizumab in the Skin of Food Allergy Patients
NCT06618963
Recruiting
The goal of this interventional study is to evaluate whether skin barrier abnormalities occur in subjects with a food allergy, as determined by positive oral food challenge (OFC). The main question it aims to answer is whether these skin barrier abnormalities can be reversed by omalizumab. If there is a comparison group: Researchers will compare non-food allergic participants (who do not receive omalizumab) to see if they experience skin barrier abnormalities. All food allergic participants wi... Read More
Gender:
ALL
Ages:
Between 1 year and 55 years
Trial Updated:
04/29/2025
Locations: National Jewish Health, Denver, Colorado
Conditions: Food Allergy, Food Allergy in Children
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Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength
NCT06607913
Recruiting
The aging Veteran population has more frequent inpatient hospitalization than non-Veterans. In addition, older Veterans have an inability to fully recover muscle mass and function after hospital-acquired weakness. The problem of hospital-acquired weakness is greatly increased in at-risk Veteran populations such as those with chronic kidney disease (CKD). The purpose of this collaborative study involving Denver and Baltimore VAMC sites is to improve health through the detection and rehabilitation... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
04/29/2025
Locations: Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado
Conditions: Chronic Kidney Disease (CKD)
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Global Paradise System US Post Approval Study
NCT06297291
Recruiting
The objective of the Global Paradise® System US Post Approval Study (US GPS) is to evaluate the real-world use of the Paradise Ultrasound Renal Denervation System indicated for patients who are unable to lower their blood pressure with lifestyle changes and medication. This system is comprised of a catheter, cable, balloon, and generator and has received FDA approval in the United States. Information collected in this study will be analyzed to better understand the long-term safety and effective... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: Rocky Mountain Regional VAMC, Aurora, Colorado
Conditions: Hypertension, Cardiovascular Diseases, Vascular Diseases
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