Illinois is currently home to 2618 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Chicago, Peoria, Springfield and Urbana. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Mucopolysaccharidosis I (MPS I) Registry
NCT00144794
Recruiting
The Mucopolysaccharidosis I (MPS I) Registry is an ongoing, observational database that tracks the outcomes of patients with MPS I. The data collected by the MPS I Registry will provide information to better characterize the natural history and progression of MPS I as well as the clinical responses of patients receiving enzyme replacement therapy, such as Aldurazyme (Recombinant Human Alpha-L-Iduronidase), or other treatment modalities. The objectives of the Registry are: * To evaluate the lon... Read More
Gender:
ALL
Ages:
All
Trial Updated:
11/19/2024
Locations: Ann and Robert Lurie Children's Hospital- Site Number : 840011, Chicago, Illinois
Conditions: Mucopolysaccharidosis I (MPS I)
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Noradrenergic Dysregulation, Sleep and Cognition in Older Adults with Insomnia
NCT06694441
Recruiting
This study investigates the relationship between the noradrenergic (NA) system, sleep quality, and cognitive function in older adults with insomnia - a population at elevated risk for Alzheimer's disease-related dementias (ADRD) - compared to age and sex matched controls with normal sleep. The study characterizes NA function through multiple approaches: measuring 24-hour plasma levels of norepinephrine (NE) and its brain metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG); evaluating central NA sy... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
11/18/2024
Locations: Northwestern University Feinberg School of Medicine, Center for Circadian and Sleep Medicine, Chicago, Illinois
Conditions: Insomnia
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Testing a Real-time Electronic Antiretroviral Adherence Monitoring Intervention
NCT06550804
Recruiting
The investigators propose using an electronic adherence device that is basically a pill container that can alert when it is not opened at a scheduled time. The investigators will use this device to alert the medication user at the time when medication is supposed to be taken if the device did not get opened and a pre-identified social support person or case manager when 2 or 7 consecutive days of nonadherence are detected, respectively. The investigators call our approach "A-Team" (Antiretrovira... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: University of Illinois Chicago, Chicago, Illinois
Conditions: HIV Infections, Adherence, Medication
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J-RISE: Relevant Implementation Strategies to Eliminate the Social and Structural Barriers to HIV Services Among Justice-involved Black Men Who Have Sex With Men and Other Key Populations
NCT06477588
Recruiting
The goal of this clinical trial is to compare two interventions - Health Navigation and Health Navigation Plus among individuals who have been impacted by the criminal legal system. The main question it aims to answer is: • Compared with the Health Navigation group, are participants in the Health Navigation Plus group more likely to a) access HIV care, treatment, and prevention services and employment services and b) access employment services and be employed in community? Participants on the... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: University of Chicago, Chicago, Illinois
Conditions: HIV, Contingency Management, Justice Involved Populations, Status Neutral Interventions
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A Study to Assess the Efficacy, Safety, and Tolerability of Oral NORA520 in Adults With Severe Postpartum Depression
NCT06285916
Recruiting
The purpose of this research study is to test the study drug, NORA520, as a possible treatment for severe postpartum depression (PPD). The trial aims to determine: * How well NORA520 is tolerated and what side effects it may cause * If NORA520 reduces depressive symptoms in subjects with severe PPD * The amount of NORA520 in the blood at various times after taking the study drug; this provides information that helps determine how often NORA520 should be taken * In a subset of subjects, the amou... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
11/18/2024
Locations: Gerbera site, Chicago, Illinois
Conditions: Depression, Postpartum, Postpartum Depression, Post-partum Depression, Postnatal Depression, Post-Natal Depression
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The REACTplusNMES Trial: a Double-blinded RCT
NCT06127602
Recruiting
The aim of this study is to compare the effectiveness of 6-weeks of reactive balance training (REACT) with and without neuromuscular electrical stimulation (NMES) to paretic lower limb muscles on biomechanical, clinical, neuromuscular and neuroplastic outcomes of reactive balance control. This project is a Phase-I study and incorporates a double-blinded, randomized controlled trial design. Methods: Forty-six individuals with chronic stroke will be recruited and screened for determining their el... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
11/18/2024
Locations: University of Illinois at Chicago, Chicago, Illinois
Conditions: Stroke, Ischemic, Stroke Hemorrhagic, Stroke, Cerebrovascular
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Study of KITE-197 in Participants With Relapsed or Refractory Large B-cell Lymphoma
NCT06079164
Recruiting
This study will have two Phases: Phase 1a and Phase 1b. The goal of Phase 1a of this clinical study is to learn more about the safety, tolerability and dosing of study drug KITE-197, in participants with relapsed or refractory large B-cell lymphoma (r/rLBCL). The goal of Phase 1b of this clinical study is learn about the effectiveness of the recommended dose of KITE-197 in participants with r/r LBCL. The primary objectives of this study are: Phase 1a: To evaluate the safety of KITE-197 in part... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: University of Chicago Medical Center, Chicago, Illinois
Conditions: Relapsed/Refractory Large B-cell Lymphoma
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Effects of TNF Blockade on Human BPH/LUTS
NCT06062875
Recruiting
Specific Aim 1. To evaluate the efficacy of TNF antagonist action in BPH/LUTS Specific Aim 2. Define the consequences of TNF antagonist therapy on prostate tissue Specific Aim 3. Identify genetic predictors to stratify patients with differential response to TNF-antagonist therapy.
Gender:
MALE
Ages:
Between 45 years and 80 years
Trial Updated:
11/18/2024
Locations: NorthShore University HealthSystem, Glenview, Illinois
Conditions: Benign Prostatic Hyperplasia (BPH)
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Lung Cancer Screening in High-risk Black Women
NCT05898594
Recruiting
The goal of this research study is to study U.S. Black women with a history of smoking to examine the feasibility, acceptability, and performance of low-dose computed tomography (LDCT) screening among this population. The name of the intervention used in this research study is: Low-dose computed tomography (radiologic scan) chest scan
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: University of Chicago, Chicago, Illinois
Conditions: Lung Cancer, Lung Carcinoma
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A Novel Measurement Concept to Objectively Quantify Severity of Vocal and Speech Related Symptoms Associated With Parkinson's Disease
NCT05421832
Recruiting
The aim of this research program is to develop and validate a smartphone app-based digital measurement concept that: * Objectively quantifies the severity of Parkinson's Disease (PD) related vocal and speech symptoms; * Accurately and sensitively identifies vocal and speech abnormalities associated with the prodromal stage of PD.
Gender:
ALL
Ages:
30 years and above
Trial Updated:
11/18/2024
Locations: Northwestern University, Chicago, Illinois
Conditions: Parkinson Disease
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Study of the Long-Term Safety and Outcomes of Treating Pulmonary Embolism With the Indigo Aspiration System
NCT04798261
Recruiting
The objective of this study is to evaluate real world long-term functional outcomes, safety and performance of the Indigo Aspiration System for the treatment of pulmonary embolism (PE).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: Loyola University Medical Center, Maywood, Illinois
Conditions: Pulmonary Embolism
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Optimizing Y90 Therapy for Radiation Lobectomy
NCT04390724
Recruiting
HCC resection candidates with inadequate future liver remnant will be enrolled in this study. They will be treated with Y90 radioembolization to help grow the liver enough to undergo liver resection. There will be 2 Patient Groups. The first group of patients will be treated with Y90 dose and embolic load as per standard-of-care. The second group of patients will be treated with the optimal Y90 dose and embolic load found in Patient Group 1.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: Northwestern University, Chicago, Illinois
Conditions: HCC, Resection, Transplant, Metastatic Cancer, Adult Primary Liver Cancer
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