Illinois is currently home to 2669 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Chicago, Peoria, Springfield and Urbana. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Avelumab or Hydroxychloroquine with or Without Palbociclib to Eliminate Dormant Breast Cancer
NCT04841148
Recruiting
This clinical trial will assess the safety and early efficacy of Hydroxychloroquine or Avelumab, with or without Palbociclib, in early-stage ER+ breast cancer patients who are found to harbor disseminated tumor cells (DTCs) in the bone marrow after definitive surgery and standard adjuvant therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: University of Chicago, Chicago, Illinois
Conditions: Breast Cancer
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Musculoskeletal and Pelvic Floor Health in Female Chronic Overlapping Pelvic Pain Conditions
NCT05750212
Recruiting
The purpose of this study is to learn about nerve function and pelvic muscle function. To do this we will compare the pelvic nerve and muscle function of women with chronic pelvic pain to those who do not have chronic pelvic pain. Understanding the pain may lead to better treatments in the future.
Gender:
FEMALE
Ages:
Between 21 years and 80 years
Trial Updated:
03/06/2025
Locations: Loyola Medical Center, Maywood, Illinois
Conditions: Chronic Pelvic Pain Syndrome
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Phase 1b Study of Dato-DXd in Combination With Immunotherapy With or Without Carboplatin in Advanced or Metastatic Non-Small Cell Lung Cancer
NCT04612751
Recruiting
This study will assess safety, tolerability, and treatment activity of datopotamab deruxtecan (Dato-DXd) in combination with immunotherapy with or without carboplatin in participants with advanced or metastatic non-small cell lung cancer (NSCLC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/06/2025
Locations: Research Site, Chicago, Illinois
Conditions: Advanced or Metastatic NSCLC
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Bringing to Light the Risk Factors And Incidence of Neuropsychological Dysfunction in ICU Survivors, 2nd Study
NCT04305600
Recruiting
This BRAIN-ICU-2 study \[Bringing to light the Risk factors And Incidence of Neuropsychological dysfunction (dementia) in ICU Survivors, 2nd Study\] is in direct response to PAR-17-038 and will determine ICU patients' main paths to decline, maintenance, or recovery of brain function. We will answer gaps in knowledge about long-term outcome of post-ICU brain disease by following the remaining ICU survivors from the original BRAIN-ICU-1 study with complete cognitive testing for the first time ever... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/06/2025
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Critical Illness, Intensive Care Unit Delirium
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Perioperative Anticoagulant Use for Surgery Evaluation -Virtual Visit (PAUSE-Virtual)
NCT06844227
Recruiting
The purpose of the PAUSE-Virtual Study is to show that by changing pre-surgery visits with patients taking a blood thinner (direct oral anticoagulant (apixaban, dabigatran, edoxaban, rivaroxaban or warfarin) when the participant requires elective surgery, using a standard, in-person proven approach, to a virtual visit, either telephone or video conference, is as safe. Patients who are receiving a blood thinner for the medical condition known as atrial fibrillation (AF) and require an elective su... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
03/05/2025
Locations: Endeavor Health - Northshore, Evanston, Illinois
Conditions: Atrial Fibrillation (AF)
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Erector Spinae Plane Block for Acute Back Pain in the Emergency Department
NCT06745453
Recruiting
The goal of this clinical trial is to learn if an erector spinae plane block (ESPB; a type of nerve block) works to reduce pain in adults presenting to the emergency department with low back pain. It will also learn if the ESPB reduces pain, disability, and return to work at 7 days. The main questions it aims to answer are: 1. Does the ESPB reduce short-term pain in participants with low back pain? 2. Does the ESPB reduce longer-term pain, reduce disability, and improve return to work and activ... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2025
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Low Back Pain
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A Study of XTMAB-16 in Patients With Pulmonary Sarcoidosis
NCT05890729
Recruiting
A phase 1b/2 study of XTMAB-16 in patients with pulmonary sarcoidosis
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/05/2025
Locations: Xentria Investigative Site, Chicago, Illinois
Conditions: Pulmonary Sarcoidosis
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Soy Isoflavones for Inner City Infants At Risk for Asthma (SIRA) Study
NCT05667701
Recruiting
The goal of this clinical trial is to compare soy isoflavones to placebo in children who at risk of asthma and have a genetic variation which results in them making more of a pro-inflammatory protein, plasminogen activator inhibitor-1. The main questions this trail seeks to answer is: will soy isoflavones decrease the proportion of infants with aT2 high endotype at the end of treatment, and secondarily decrease the number of wheezing episodes in these children when given in the first year of lif... Read More
Gender:
ALL
Ages:
Between 2 months and 6 months
Trial Updated:
03/05/2025
Locations: Ann and Robert H Lurie Childrens Hospital of Chicago, Chicago, Illinois
Conditions: Wheezing, Asthma in Children
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Diabetic Neuropathy in Spinal Cord Stimulator Patients
NCT04687215
Recruiting
The objective of this study is to assess the effect Spinal Cord Stimulators have toward improving vascular changes of diabetes mellitus in patients eligible for SCS placement based on their condition of painful diabetic neuropathy; we will evaluate improving their disability and quality of life, improving micro-circulatory changes induced by Diabetes Mellitus (DM), improving macro-circulatory changes induced by DM and improving arterial stiffness of the vessels of the lower extremity.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2025
Locations: University of Chicago Medical Center, Chicago, Illinois
Conditions: Diabetes Mellitus, Neuropathy, Neuropathic Pain, Vascular Diseases, Vascular Stiffness, Microvascular Changes, Pain, Chronic
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AYA OMGYES Sexual Health Study
NCT06868121
Recruiting
The purpose of this study is to assess the impact of the web-based intervention OMGYES.com on sexual dysfunction in young adult (YA) female-bodied cancer survivors. This pilot trial seeks to evaluate the intervention's: * feasibility * acceptability * appropriateness. Researchers will utilize an active observation period to compare outcomes between those receiving the intervention immediately and those who haven't Participants will: * Complete online modules at home * Visit the clinic every... Read More
Gender:
FEMALE
Ages:
Between 18 years and 40 years
Trial Updated:
03/04/2025
Locations: University of Chicago Hospital, Chicago, Illinois
Conditions: Sexual Dysfunction
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Validation and Scaling of Screening Program for Undiagnosed Myasthenia Gravis-Social Media Campaign Paired With a Self-moderated Assessment
NCT06866483
Recruiting
This study expands and validates the pilot study NCT06381284. It is a fully remote, site-less, prospective, observational study enrolling adults in the United States (excluding U.S. territories) with undiagnosed neuromuscular symptoms. The primary objective is to determine the validity of a self-assessment tool in encouraging undiagnosed participants, recruited through a social media campaign, to seek medical evaluation for suspected myasthenia gravis (MG).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2025
Locations: ZS Associates, Evanston, Illinois
Conditions: Myasthenia Gravis, Neuromuscular Disease, Neuromuscular Manifestations
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Prophylactic Conjoint Tendon Lengthening During Reverse Shoulder Arthroplasty Outcomes
NCT06729983
Recruiting
Some patients may experience persistent pain in the front of their shoulder after reverse shoulder replacement. One of the possible reasons for this is that the surgery causes a change in the alignment of the shoulder joint, which may cause increased tension and compression on one of the biceps tendon called the conjoint tendon. The purpose of this study is to evaluate whether conjoint tendon lengthening, a surgical procedure that involves cutting and lengthening the conjoint tendon in order to... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2025
Locations: Loyola Outpatient Center, Maywood, Illinois
Conditions: Osteoarthritis Shoulder
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