Illinois is currently home to 2634 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Chicago, Peoria, Springfield and Urbana. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction
NCT06517186
Recruiting
The purpose of this study is to identify changes in heart tissue structure and biological function in patients with heart failure by performing an endomyocardial biopsy (EMB or heart biopsy) during a right heart catheterization (RHC). The ultimate goal is to use this information to develop new treatments for heart failure.
Gender:
ALL
Ages:
30 years and above
Trial Updated:
11/14/2024
Locations: Northwestern University, Chicago, Illinois
Conditions: Heart Failure, Heart Failure With Preserved Ejection Fraction
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Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer
NCT06475989
Recruiting
This phase III trial compares the effect of cabozantinib versus combination dabrafenib and trametinib for the treatment of patients with differentiated thyroid cancer that does not respond to treatment (refractory) and which expresses a BRAF V600E mutation. Cabozantinib is in a class of medications called receptor tyrosine kinase inhibitors. It binds to and blocks the action of several enzymes which are often over-expressed in a variety of tumor cell types. This may help stop or slow the growth... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/14/2024
Locations: OSF Saint Anthony's Health Center, Alton, Illinois
Conditions: Refractory Differentiated Thyroid Gland Carcinoma
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Ovarian Tissue Cryopreservation in Post Pubertal (OTC-Post Pubertal)
NCT05309746
Recruiting
The purpose of this study is to safely remove ovarian tissue in pediatric patients, who are at risk for infertility from their medical treatment, for freezing for future restoration of fertility and hormone function.
Gender:
FEMALE
Ages:
30 years and below
Trial Updated:
11/14/2024
Locations: Ann &Robert H Lurie Children's Hospital, Chicago, Illinois
Conditions: Pediatric Cancer
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Ovarian Tissue Cryopreservation in Pre-Pubertal (OTC-Pre Pubertal)
NCT05299710
Recruiting
The purpose of this study is to safely remove ovarian tissue in pre-pubertal pediatric patients, who are at risk for infertility from their medical treatment, for freezing for future restoration of fertility and hormone function.
Gender:
FEMALE
Ages:
11 years and below
Trial Updated:
11/14/2024
Locations: Ann & Robert H Lurie Childrens Hospital, Chicago, Illinois
Conditions: Cancers
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The Pediatric ALL Evaluation and Trial
NCT04825587
Recruiting
The overall aim of this multicenter RCT is to determine whether concomitant ALL reconstruction in children undergoing and ACL reconstruction will longitudinally result in a lower rate of graft failure than ACL reconstruction alone.
Gender:
ALL
Ages:
18 years and below
Trial Updated:
11/14/2024
Locations: Lurie Children's Hospital, Chicago, Illinois
Conditions: ACL Injury, ACL Tear
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Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal Epilepsy
NCT04770337
Recruiting
This is a multiple site, randomized, double blinded parallel-group controlled study. The purpose of this study is to evaluate efficacy, safety, and tolerability of repeated, daily sessions with the STARSTIM device, which delivers transcranial cathodal direct current stimulation (tDCS). Subjects will be treated with STARTSTIM or sham device for 10 sessions over a 2-week period. The subjects will be followed for an additional 10 weeks post treatment. Quality of Life questionnaires and adverse even... Read More
Gender:
ALL
Ages:
9 years and above
Trial Updated:
11/14/2024
Locations: Southern Illinois University School of Medicine, Springfield, Illinois
Conditions: Refractory Epilepsy, Focal Seizure, Seizures, Focal, Seizures, Epilepsy in Children, Epilepsy, Epilepsy, Tonic-Clonic
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Anti-mullerian Hormone Levels in Healthy Females
NCT04537390
Recruiting
The purpose of this study is to have a better understanding of the normal blood levels of AMH in females from 0-18 years of age and how the blood AMH levels correspond to a female's reproductive development.
Gender:
FEMALE
Ages:
18 years and below
Trial Updated:
11/14/2024
Locations: Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois
Conditions: Healthy
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Pediatric Ovarian Tissue Banking - Operative Specimens From Females 0-18 Years of Age
NCT04118712
Recruiting
A child is eligible to participate in this study because she is having surgery on her ovary. The investigators may obtain a sample of any discarded tissue from the surgery for an ovarian tissue library. This study is being conducted to understand how common ovarian conditions effect the number and quality of ovarian follicles and the reproductive potential of the ovary.
Gender:
FEMALE
Ages:
18 years and below
Trial Updated:
11/14/2024
Locations: Ann & Robert H Lurie Childrens Hospital, Chicago, Illinois
Conditions: Benign Cysts Ovarian, Cystectomy, Torsion, Malignant Cysts Ovarian
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Training for Urinary Leakage Improvement After Pregnancy
NCT06411158
Recruiting
This is a multi-center, randomized single-blind nonsurgical trial conducted in approximately 216 primiparous postpartum women at high risk for prolonged/sustained pelvic floor disorders with symptomatic, bothersome urinary incontinence (UI) amenable to nonsurgical treatment. TULIP is a 3-Arm trial with two active interventions (Arms 1 and 2) and a Patient Education control arm (Arm 3). Arm 1 consists of pelvic floor muscle training (PFMT). Arm 2 uses a home biofeedback device (leva®). The prim... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: University of Chicago, Chicago, Illinois
Conditions: Urinary Incontinence, Delivery Complication
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Comparing Magnesium 2g Versus 4g Versus Placebo in the Incidence of Treating AFF RVR
NCT06376916
Recruiting
The purpose of this prospective, randomized, double-blinded study is to further evaluate the safety and efficacy of varying doses of intravenous magnesium in the treatment of AFF RVR.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: Advocate Christ Medical Center Emergency Department (ACMC ED), Oak Lawn, Illinois
Conditions: Tachycardia Atrial, Atrial Fibrillation, Atrial Flutter With Rapid Ventricular Response
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Pharmacokinetics, Pharmacodynamics and Safety of Epeleuton in Patients with Sickle Cell Disease
NCT05861453
Recruiting
To assess the pharmacokinetics, pharmacodynamics and safety of Epeleuton capsules in adult SCD patients who are aged ≥18 years.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: UI Health Sickle Cell Center, Chicago, Illinois
Conditions: Sickle Cell Disease
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Eosinophilic Gastrointestinal Disorders Registry
NCT05199532
Recruiting
The purpose of this study is to learn more about Eosinophilic Gastrointestinal Disorders (EGIDs). With this registry we hope to find out more about the symptoms that patients have during their treatment, the quality of life they have with the diagnosis, what the disease looks like throughout the different treatment methods, and if there is a connection between EGIDs and connective tissue disorders. The goal of this study is to be able to better understand EGIDs and use information gained from a... Read More
Gender:
ALL
Ages:
Between 1 year and 25 years
Trial Updated:
11/13/2024
Locations: Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois
Conditions: Eosinophilic Esophagitis, Eosinophilic Gastroenteritis, Eosinophilic Colitis, Eosinophilic Gastrointestinal Disease
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