Illinois is currently home to 2681 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Chicago, Peoria, Springfield and Urbana. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).
NCT04408430
Recruiting
A prospective multicenter study enrolling high surgical risk patients with severe mitral annular calcification (MAC) and symptomatic mitral valve dysfunction (severe stenosis, ≥ moderate to severe regurgitation, or mixed ≥ moderate stenosis and ≥ regurgitation). There are 2 Arms in this study: 1) "Transseptal (TS) Valve-in-MAC" (ViMAC) Arm, and 2) Natural History of Disease Registry (NHDR) for patients treated with medical treatment only (which includes patients who meet inclusion criteria but c... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/18/2024
Locations: Northwestern University Medical School, Chicago, Illinois
Conditions: Mitral Annular Calcification, Mitral Stenosis, Mitral Regurgitation, Mitral Valve Disease
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Bupropion to Reduce Cancer Related Fatigue in Cancer Survivors
NCT03996265
Recruiting
This phase III trial studies how well bupropion works in reducing cancer related fatigue in cancer survivors. Bupropion is a drug that is used to treat depression, as well as to help people quit smoking. Cancer and its treatment can cause fatigue. Giving bupropion may improve cancer related fatigue in cancer survivors.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/18/2024
Locations: Saint Anthony's Health, Alton, Illinois
Conditions: Be Diagnosed With Cancer and Have Completed Systemic Therapy
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Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2
NCT05555589
Recruiting
The objective of this study is to compare the safety and efficacy of RGN-259 to placebo for the treatment of Neurotrophic Keratopathy (NK)
Gender:
All
Ages:
18 years and above
Trial Updated:
04/17/2024
Locations: Northwestern, Chicago, Illinois
Conditions: Neurotrophic Keratopathy
Register for Updates
Examining Digital Health Care Delivery Models Through Medicaid Collaborative
NCT05555095
Recruiting
The purpose of this study is to examine the intervention effectiveness and dissemination of digital health care delivery models for improving selected health outcomes in the Medicaid population.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/17/2024
Locations: OSF HealthCare System, Peoria, Illinois
Conditions: Hypertension, Diabetes Mellitus, Maternal Health
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PMCF Study to Evaluate the VERTICALE® Cervical System in Spine Surgery According to Its Intended Use.
NCT05489822
Recruiting
In accordance with the European Medical Device Regulation MDR 2017/745/EU, the legal manufacturers of medical devices are obliged to evaluate medical devices with regard to their clinical performance and safety. The VERTICALE® Cervical System is intended for immobilization and stabilization of spinal segments of the craniocervical junction (occipital-C2), subaxial cervical spine (C3-C7) and upper thoracic spine (T1-T3). Primary Objective: To assess the functional outcome and clinical benefit... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/17/2024
Locations: University of Illinois Hospital and Health Sciences System - UI Health, Chicago, Illinois
Conditions: Degenerative Disc Disease (DDD), Instabilities, Trauma, Deformity
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Study to Evaluate the Efficacy, Safety, and Tolerability of IMU-838 in Patients With Relapsing Multiple Sclerosis
NCT05134441
Recruiting
Multi-Center, Randomized, Double-Blinded Phase 3 Study to Evaluate the Efficacy, Safety, and Tolerability of IMU-838 versus Placebo in Adults with Relapsing Multiple Sclerosis (ENSURE-1)
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
04/17/2024
Locations: Consultants in Neurology, Ltd, Northbrook, Illinois
Conditions: Multiple Sclerosis
Register for Updates
Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation
NCT01656603
Recruiting
This study will evaluate the safety of infusion of the investigational cord blood units by carefully documenting all infusion-related problems.
Gender:
All
Ages:
All
Trial Updated:
04/17/2024
Locations: Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois
Conditions: Infusion Reactions
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Pre-IVF Treatment With a GnRH Antagonist in Women With endometriosis_temp
NCT06375811
Recruiting
A Phase 3 clinical trial of oral GnRH antagonist pre-treatment for women with endometriosis who are undergoing IVF, with a primary outcome of live birth rate. The investigators' central hypothesis is that in infertile woman with endometriosis undergoing in vitro fertilization-embryo transfer (IVF-ET), live birth rates will improve in those pretreated with GnRH antagonist compared to those not pretreated with GnRH antagonist.
Gender:
Female
Ages:
Between 18 years and 40 years
Trial Updated:
04/16/2024
Locations: Northwestern University Department of Obstetrics and Gynecology, Chicago, Illinois
Conditions: Infertility, Endometriosis
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Plants Optimizing Development Study (PODS)
NCT06276426
Recruiting
This study aims to conduct a randomized clinical trial to measure the effects of a 3-month daily mixed-soy food intervention vs. a control group receiving isocaloric foods on reproductive hormones, body composition, metabolic risk, fecal microbiota, and cognition among 8-11-year-old children. Additionally, this study will assess soy food intake immediately following participation in the clinical trial to determine changes in soy food acceptance in children.
Gender:
All
Ages:
Between 8 years and 11 years
Trial Updated:
04/16/2024
Locations: University of Illinois, Urbana, Illinois
Conditions: Healthy Children
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A Feasibility Study of a Novel, Fully Remote Counseling and Sound Therapy Program for Hyperacusis
NCT05976789
Recruiting
There is no universal approach used to treat hyperacusis, a condition defined as having reactions to sound as too loud, annoying, fearful, or painful. A collaborative report published by prominent researchers recommended counseling and sound therapy for managing hyperacusis, but emphasized the need for rigorously designed clinical trials to assess the effectiveness of these treatments. The investigators developed a face-to-face counseling approach, Hyperacusis Activities Treatment (HAT), and hav... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/16/2024
Locations: Augustana College, Rock Island, Illinois
Conditions: Hyperacusis
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Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study
NCT05677880
Recruiting
This is an observational study to better understand the risk factors and progression of CADASIL, a leading cause of vascular cognitive impairment and dementia (VCID). 500 participants will be enrolled and can expect to be on study for up to 5 years.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/16/2024
Locations: Loyola University, Chicago, Illinois
Conditions: CADASIL
Register for Updates
Clinical Trial to Evaluate the Safety and Efficacy of DWN12088 in Patients With IPF
NCT05389215
Recruiting
This is a randomized, double-blinded, placebo-controlled multicenter study to evaluate the safety and efficacy of DWN12088 in patients with Idiopathic Pulmonary Fibrosis.
Gender:
All
Ages:
40 years and above
Trial Updated:
04/16/2024
Locations: Loyola University Medical Center (LUMC), Maywood, Illinois
Conditions: Idiopathic Pulmonary Fibrosis
Register for Updates