Illinois is currently home to 2669 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Chicago, Peoria, Springfield and Urbana. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Beyond MARS: Magnetic Resonance Study: A Novel Assessment of Placental Perfusion During Pregnancy
NCT06314009
Recruiting
The purpose of this study is to evaluate the flow of oxygen and blood necessary for nutrient transfer across the placenta during the second and third trimesters in pregnancy in women who are obese before pregnancy compared to women who have an average weight before pregnancy. This study will evaluate blood flow across the placenta by functional Magnetic Resonance Imaging (fMRI) using arterial spin labeling (ASL). The investigators hypothesize that there will be differences in placental oxygenati... Read More
Gender:
FEMALE
Ages:
Between 18 years and 60 years
Trial Updated:
12/04/2024
Locations: NorthShore University HealthSystem, Evanston, Illinois
Conditions: Placenta Diseases
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Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies
NCT05476770
Recruiting
Tagraxofusp is a protein-drug conjugate consisting of a diphtheria toxin redirected to target CD123 has been approved for treatment in pediatric and adult patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN). This trial aims to examine the safety of this novel agent in pediatric patients with relapsed/refractory hematologic malignancies. The mechanism by which tagraxofusp kills cells is distinct from that of conventional chemotherapy. Tagraxofusp directly targets CD123 that is pre... Read More
Gender:
ALL
Ages:
Between 1 year and 21 years
Trial Updated:
12/04/2024
Locations: Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois
Conditions: Hematologic Malignancy, AML, ALL, BPDCN, MDS, Lymphoblastic Lymphoma, Lymphoma, B-Cell, Lymphoma, T-Cell, Hodgkin Lymphoma, Mixed Phenotype Acute Leukemia, Acute Undifferentiated Leukemia
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Vasoactive Drugs in Intensive Care Unit
NCT02118467
Recruiting
The investigators hypothesis is that for ICU patients with shock, the use of the vasoactive drugs phenylephrine and vasopressin will reduce tachydysrhythmias when compared to norepinephrine and epinephrine. To investigate this hypothesis, the investigators are conducting a randomized double blind controlled trial comparing phenylephrine and vasopressin vs. norepinephrine and epinephrine in ICU patients with shock that is not responsive to IV fluids. All patients admitted to the adult intensive c... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/04/2024
Locations: University of Chicago Medical Center, Chicago, Illinois
Conditions: Shock
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Effects of Vibration on Motor Function of Survivors of Chronic Stroke
NCT06663501
Recruiting
The aim of this study is to evaluate how vibration of the tendons enhances arm and hand training in survivors of chronic stroke. The investigators hypothesize that wrist/elbow robotic training, combined with body awareness training will improve arm and hand function in individuals with chronic stroke.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
12/03/2024
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Stroke, Healthy
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Enhancing Immune Health Randomized Controlled Trial
NCT05639881
Recruiting
This study tests a psychosocial intervention to improve immune health literacy and behaviors among adults with mental illnesses.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: University of Illinois Chicago, Chicago, Illinois
Conditions: Mental Disorder
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Antidepressant Effects of Nitrous Oxide
NCT05357040
Recruiting
To evaluate the acute and sustained antidepressant effects of nitrous oxide in people with major depressive disorder; and further evaluate these effects by identifying the optimal dose and regimen to guide current practice, and to plan a future large pragmatic trial.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: University of Chicago Medicine, Chicago, Illinois
Conditions: Major Depressive Disorder, Treatment Resistant Depression
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Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age
NCT05336890
Recruiting
Despite improved survival of extremely premature infants in recent decades, neonatal intensive care unit (NICU) graduates are diagnosed with asthma, sleep disordered breathing (SDB) in childhood, and neurodevelopmental impairments (NDI) at significant rates, disproportionate to their term peers. Early detection and intervention are critical to mitigate the impact of these impairments. Mechanisms leading from premature birth to these undesirable outcomes remain unclear, and accurate prognostic me... Read More
Gender:
ALL
Ages:
Between 30 weeks and 83 months
Trial Updated:
12/03/2024
Locations: Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois
Conditions: Premature Birth, Asthma in Children, Sleep-Disordered Breathing, Neurodevelopmental Disorders
Register for Updates
Oral Statins and Protection From Hearing Loss
NCT04826237
Recruiting
A small clinical trial for idiopathic sudden sensorineural hearing loss (ISSNHL). Will the addition of an oral statin to the standard treatment (oral methylprednesolone and the salvage therapy of intratympanic dexamethasone) improve the treatment outcome for patients with ISSNHL? This study will compare the two treatments and quantitatively evaluate hearing and speech discrimination and have the patients subjectively evaluate tinnitus.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
12/03/2024
Locations: Northwestern Memorial Hospital, Chicago, Illinois
Conditions: Sudden Sensorineural Hearing Loss
Register for Updates
Optimizing Tobacco Use Treatment for PLWHA
NCT04176172
Recruiting
The advent of anti-retroviral therapy (ART) for people living with HIV/AIDS (PLWHA) substantially improved life expectancy but has also led to the critical need to address modifiable risk factors associated with cancer and cardiovascular disease, such as tobacco smoking. HIV-infected smokers lose more life-years due to tobacco use than they do to their HIV infection. There have been relatively few studies of tobacco use treatments for PLWHA and systematic reviews show that there are insufficien... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: Northwestern University, Chicago, Illinois
Conditions: HIV/AIDS, Nicotine Dependence
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Black and African Americans Connections to Parkinson's Disease (BLAAC PD)
NCT06719583
Recruiting
BLAAC PD is a research study to understand what Parkinson's disease looks like for Black and African American communities. BLAAC PD is happening at research centers around the United States. The study is part of the Global Parkinson's Genetics Program (GP2). GP2 is a research project working to transform understanding of the genetics of Parkinson's disease and make that knowledge globally relevant.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/02/2024
Locations: Rush University, Chicago, Illinois
Conditions: Parkinson Disease
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Hyrax Vs. Invisalign Palatal Expander Clinical Study
NCT06662279
Recruiting
The purpose of this study is to compare expansion result and the overall experience between the Invisalign Palatal Expander and the Hyrax expander.
Gender:
ALL
Ages:
Between 6 years and 11 years
Trial Updated:
12/02/2024
Locations: Innovative Orthodontic Centers, Naperville, Illinois
Conditions: Malocclusions, Narrow Maxilla, Narrow Maxillary Arch, Crowding
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Executive Function and Parenting in Childhood
NCT06241300
Recruiting
Deficits in executive functioning (EF) disproportionately impact children living in poverty and increase risk for psychopathology, particularly disruptive behavior disorders. This randomized clinical trial seeks to determine whether childhood EF, assessed across neural and behavioral units of analysis, is an experimental therapeutic target that can be directly modified through caregiver participation in the Chicago Parent Program (CPP), if increases in EF predict reduced disruptive behavior traj... Read More
Gender:
ALL
Ages:
4 years and above
Trial Updated:
12/02/2024
Locations: University of Illinois-Chicago, Chicago, Illinois
Conditions: Disruptive Behavior Disorder, Childhood Onset, Disruptive Behavior, Executive Function
Register for Updates