Massachusetts is currently home to 3192 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Gemcitabine and Cisplatin Without Cystectomy for Patients With Muscle Invasive Bladder Urothelial Cancer and Select Genetic Alterations
NCT03609216
Recruiting
This phase II trial studies how well gemcitabine hydrochloride and cisplatin work in treating participants with invasive bladder urothelial cancer. Drugs used in chemotherapy, such as gemcitabine hydrochloride and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/28/2025
Locations: Mercy Medical Center, Springfield, Massachusetts
Conditions: Infiltrating Bladder Urothelial Carcinoma, Stage II Bladder Urothelial Carcinoma, Stage III Bladder Urothelial Carcinoma
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Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas
NCT02523014
Recruiting
This phase II trial studies how well vismodegib, focal adhesion kinase (FAK) inhibitor GSK2256098, and capivasertib work in treating patients with meningioma that is growing, spreading, or getting worse (progressive). Vismodegib, FAK inhibitor GSK2256098, capivasertib, and abemaciclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/28/2025
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: Intracranial Meningioma, Recurrent Meningioma, NF2 Gene Mutation
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A Study of PT0253 in Participants With KRAS G12D Mutated Advanced Solid Tumors
NCT06797336
Recruiting
The primary purpose of this study is to evaluate the safety and tolerability, determine the maximally tolerated dose (MTD) and/or recommended Phase 2 dose(s) (RP2D) of PT0253 in adult participants with Kirsten rat sarcoma viral oncogene homolog (KRAS) G12D mutated advanced solid tumors as monotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: Dana Farber/Massachusetts General Hospital, Inc, Boston, Massachusetts
Conditions: Solid Tumor
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Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease
NCT06538311
Recruiting
In this research study we want to learn more about the effects of non-invasive brain stimulation on memory and brain-network function in cognitively unimpaired older adults and in patients with amnestic mild cognitive impairment (aMCI). This study will use a form of non-invasive brain stimulation called repetitive Transcranial Magnetic Stimulation (rTMS). rTMS will slightly alter activity in an area of your brain that controls memory. Changes resulting from this stimulation will be measured wit... Read More
Gender:
ALL
Ages:
Between 40 years and 99 years
Trial Updated:
03/27/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Alzheimer Disease, Mild Cognitive Impairment, Logopenic Progressive Aphasia, Amnestic Symptoms
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Romosozumab as an Adjunct to Physiologic Estrogen Replacement in Functional Hypothalamic Amenorrhea
NCT06533865
Recruiting
The goal of this study is to determine whether romosozumab will improve bone density in girls and women with functional hypothalamic amenorrhea (cessation of the menstrual period due to intense exercise, stress, or an eating disorder) who have low bone density. Participants will be randomly assigned to receive romosozumab or placebo for 6 months. All participants will receive one IV infusion of zoledronate at the 6 month visit. All participants will also receive transdermal estradiol and cyclic... Read More
Gender:
FEMALE
Ages:
Between 14 years and 25 years
Trial Updated:
03/27/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: FHA (Functional Hypothalamic Amenorrhea)
Register for Updates
A Mixed Methods Pilot Trial of the STEP Home Workshop to Improve Reintegration and Reduce Suicide Risk for Recently Transitioned Veterans
NCT05995678
Recruiting
Risk of Veteran suicide is elevated during the first year of transition from military service to civilian life. Most Veteran suicides occur among Veterans who are not connected to VA healthcare. Suicide prevention and connection to care are therefore critical for recently transitioning Veterans. Transitioning Veterans require services to provide them with suicide prevention education, skills to manage their transition effectively, and support in their access to VA healthcare. Convenient, accessi... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/27/2025
Locations: VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts
Conditions: TBI, Suicide Prevention, Veterans, PTSD, Transdiagnostic, Anger
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Dotarem vs Gadobutrol Contrast for Breast MRI
NCT03730051
Recruiting
In this randomized clinical trial, the investigators expect to demonstrate that the MRI contrast agent Dotarem is not less effective in contrast enhancement of breast lesions then Gadavist. Participants will be randomized to receive either Dotarem or Gadavist. In all cases, inclusion criteria will require patients having undergone or scheduled or most likely to be scheduled to undergo tissue sampling with histology results available. The patients will be prospectively and consecutively identifie... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: UMass Medical School, Worcester, Massachusetts
Conditions: Breast Diseases
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Mind Body Intervention for Chronic Upper Extremity Pain (Repetitive Stress Injury)
NCT06903962
Recruiting
The goal of this nonrandomized pilot study is to test a mind-body interventional approach for the treatment of chronic upper extremity pain or repetitive stress injury of the upper extremity (wrist/shoulder/elbow). 1. To determine if a mind-body intervention improves upper extremity functional capacity (ie., Disability of Arm Shoulder Hand - DASH) among people with chronic wrist, elbow, and shoulder pain 2. To determine if a mind-body intervention decreases pain intensity, pain-related anxiety,... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
03/26/2025
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Chronic Pain, Chronic Pain Syndrome, Repetitive Stress Injury
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Virtual Reality Guided Acupuncture Imagery Treatment for Chronic Low Back Pain
NCT06814470
Recruiting
Testing the effect of Virtual Reality - guided imagery acupuncture
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/26/2025
Locations: Lucy Chen, Charlestown, Massachusetts
Conditions: Chronic Low-back Pain
Register for Updates
A Clinical Trial to Study the Feasibility and Acceptability of an App to Support Pediatric Resuscitation
NCT06768099
Recruiting
The goal of this clinicial trial is to test the acceptability and feasibility of linear cognitive aid intervention to support EMS teams in responding to pediatric emergencies. We are testing the hypothesis that cognitive aids with linear logic will be feasible to use and acceptable to EMS teams in urban and rural areas. Researchers will compare technical performance, teamwork, and self-assessed cognitive load of participants to see the difference between performing resuscitations using their cu... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2025
Locations: 20 Overland 4th floor, Boston, Massachusetts
Conditions: Pediatric Emergency Medicine, Resuscitation, Pediatrics, Emergency Medical Services, Arrest Cardio Respiratory
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An Efficacy, Safety, and Tolerability Study of VRDN-003 in Participants with Chronic Thyroid Eye Disease (TED)
NCT06625398
Recruiting
This is a clinical trial assessing the efficacy, safety, and tolerability of an investigational drug, VRDN-003, in participants with chronic Thyroid Eye Disease (TED).
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/26/2025
Locations: Massachusetts Eye and Ear, Boston, Massachusetts
Conditions: Thyroid Eye Disease
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Early Internal Fixation Versus NonOperative Care With Early Rehabilitation for LC1 Fragility Fractures of the Pelvis
NCT06496867
Recruiting
The goal of this randomized pilot study is to assess feasibility of the trial and to collect information to inform the design of a definitive trial. Adult patients ages 60 years or older with a low-energy lateral compression type 1 (LC1) pelvis fracture with \<10 mm initial displacement of the posterior pelvic ring will be eligible to participate in the study. Patients will be randomized to one of two treatment groups, early internal fixation or nonoperative care with early rehabilitation, defin... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
03/26/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Multiple Closed Pelvic Fractures with Disruption of Pelvic Ring, Fragility Fracture, Internal Fixation, Nonoperative Care
Register for Updates