Massachusetts is currently home to 3202 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Computer-based Training of Face Recollection to Improve Face Recognition in Developmental Prosopagnosia
NCT04799340
Recruiting
This study will examine the effectiveness of a cognitive training intervention targeting face recollection, repetition lag training, at improving face recognition in Developmental Prosopagnosia.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
11/23/2022
Locations: VA Boston Healthcare System, 150 S. Huntington Ave., Boston, Massachusetts
Conditions: Developmental Prosopagnosia
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Improving Spatial Perception and Speech Understanding in Multitalker Mixtures
NCT05260307
Recruiting
The purpose of this study is to investigate several approaches for improving spatial perception and speech intelligibility in multitalker listening situations for hearing-aid users. The hypotheses are that spatial perception and speech intelligibility will be improved by (1) increased high-frequency audibility, (2) speech envelope enhancement, and/or (3) appropriate sound image externalization.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/16/2022
Locations: Boston University, Boston, Massachusetts
Conditions: Hearing Loss
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Study on Allopregnanolone and Depression in Perimenopausal Women
NCT05329779
Recruiting
This study aims to identify how the progesterone metabolite allopregnanolone affects behavior and neurobiology that may underlie perimenopausal depression.
Gender:
FEMALE
Ages:
Between 40 years and 60 years
Trial Updated:
11/08/2022
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Depression
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Collection and Distribution of Biospecimens for Novel Research Uses
NCT03848962
Recruiting
iSpecimen aims to create a clinical partner network of hospitals, laboratories, academic institutions, and other healthcare organizations ("institutions") capable of providing researchers and educators ("researchers") with annotated biospecimens for use in biomarker discovery and validation; diagnostic test and instrumentation development and validation; therapeutics development; other medical research including the impact that various specimen collection and handling methods and conditions have... Read More
Gender:
ALL
Ages:
Between 1 month and 89 years
Trial Updated:
11/08/2022
Locations: iSpecimen, Lexington, Massachusetts
Conditions: Cancer, Healthy, Gastrointestinal Complication, Autoimmune Diseases, Infectious Disease, Women's Health: High-Risk Pregnancy, Dermatologic Disease, Blood Disease
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MOON Shoulder Instability-Cohort of Patients Undergoing Operative Treatment.
NCT02075775
Recruiting
This project will be a multi-center, prospective longitudinal cohort for all patients undergoing primary shoulder instability surgery, excluding isolated SLAP repairs. We will be looking for risk factors for recurrent instability, revision surgery, and poor outcomes. Patients will be asked to complete the RAND-36, ASES, Shoulder Activity, EQ-5D and WOSI outcome measures, as well as demographic and socioeconomic information. Surgeons will complete a form after surgery with information on radiogra... Read More
Gender:
ALL
Ages:
Between 12 years and 99 years
Trial Updated:
11/07/2022
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Other Instability, Shoulder, Dislocations, Subluxations, Recurrent Dislocation of Shoulder Region
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Acute Optic Neuritis Network: an International Study That Invesitages Subjects With a First-ever Episode of Acute Inflammation of the Optic Nerve
NCT05605951
Recruiting
The goal of this observational study is to longitudinally investigating subjects with inaugural acute optic neuritis (ON). The main questions it aims to answer are: * Does the time to corticosteroid treatment affect the visual outcome at 6 months in subjects with acute multiple sclerosis (MS)-, aquaporin 4-IgG positive (AQP4-IgG+) and myelin-oligodendrocyte-glycoprotein-IgG positive (MOG-IgG+) ON? * How differ clinical, structural, and laboratory biomarkers in subjects with acute ON, including... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/31/2022
Locations: Harvard Medical School, Boston, Massachusetts
Conditions: Demyelinating Diseases, Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder Attack, Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease, Optic Neuritis
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Conditioning & Open-Label Placebo (COLP) for Opioid Management in Intensive Inpatient Rehabilitation
NCT05351333
Recruiting
The use of the conditioning open-label placebo (COLP) paradigm will be studied as a dose extension method to lower opioid dosage in patients with spinal cord injury, polytrauma, and burn injury. The goal is to provide the same level of pain relief with a reduced opioid intake to diminish side effects as well as the risk of addiction associated with opioid treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/25/2022
Locations: Spaulding Rehabilitation Hospital, Charlestown, Massachusetts
Conditions: Spinal Cord Injuries, Polytrauma, Burns
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CERENOVUS Neurothrombectomy Devices Registry
NCT05591183
Recruiting
A post-market registry evaluating the EmboTrap® Revascularization Device and CERENOVUS Large Bore Catheter/ EMBOVAC Aspiration Catheter in acute ischemic stroke patients with confirmed intracranial large vessel occlusion.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/19/2022
Locations: University of Massachusetts, Worcester, Massachusetts
Conditions: Cerebral Stroke
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XACT ACE Observational Registry
NCT04950959
Recruiting
Compile real world data on the use of the XACT ACE Robotic System
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/19/2022
Locations: Lahey Hospital and Medical Center, Burlington, Massachusetts
Conditions: Tumors
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The Genomic Medicine at VA Study
NCT04331535
Recruiting
This trial will determine the clinical effectiveness of polygenic risk score testing among patients at high genetic risk for at least one of six diseases (coronary artery disease, atrial fibrillation, type 2 diabetes mellitus, colorectal cancer, breast cancer, or prostate cancer), measured by time-to-diagnosis of prevalent or incident disease over 24 months.
Gender:
ALL
Ages:
Between 50 years and 70 years
Trial Updated:
09/29/2022
Locations: VA Boston Healthcare System, Boston, Massachusetts
Conditions: Coronary Artery Disease, Atrial Fibrillation, Type 2 Diabetes, Colorectal Cancer, Breast Cancer, Prostate Cancer
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Indoor Air Quality and Respiratory Morbidity in School-Aged Children With BPD
NCT04107701
Recruiting
Investigators want to learn the role of indoor environmental exposures on respiratory symptoms, and, separately, on lung function deficits in school-aged children with bronchopulmonary dysplasia (BPD).
Gender:
ALL
Ages:
Between 6 years and 12 years
Trial Updated:
09/20/2022
Locations: Boston Childrens Hospital, Boston, Massachusetts
Conditions: Bronchopulmonary Dysplasia, Chronic Lung Disease of Newborn, Environmental Exposure
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Pharmacological Activation of HMN for OSA Aim 2
NCT03858751
Recruiting
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. OSA patients show a marked reduction in upper airway (UA) dilator muscle activity at sleep onset and this phenomenon leads to increased collapsibility of UA compared to normal subjects. In this protocol the investigators will test the effect of LTM1201AZ, LTM1201AT, LTM1201AD, LTM1201AG administered before sleep on OSA phenotype traits and OSA severity during sleep.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
09/19/2022
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Obstructive Sleep Apnea
Register for Updates