Massachusetts is currently home to 3208 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
XACT ACE Observational Registry
NCT04950959
Recruiting
Compile real world data on the use of the XACT ACE Robotic System
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/19/2022
Locations: Lahey Hospital and Medical Center, Burlington, Massachusetts
Conditions: Tumors
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The Genomic Medicine at VA Study
NCT04331535
Recruiting
This trial will determine the clinical effectiveness of polygenic risk score testing among patients at high genetic risk for at least one of six diseases (coronary artery disease, atrial fibrillation, type 2 diabetes mellitus, colorectal cancer, breast cancer, or prostate cancer), measured by time-to-diagnosis of prevalent or incident disease over 24 months.
Gender:
ALL
Ages:
Between 50 years and 70 years
Trial Updated:
09/29/2022
Locations: VA Boston Healthcare System, Boston, Massachusetts
Conditions: Coronary Artery Disease, Atrial Fibrillation, Type 2 Diabetes, Colorectal Cancer, Breast Cancer, Prostate Cancer
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Indoor Air Quality and Respiratory Morbidity in School-Aged Children With BPD
NCT04107701
Recruiting
Investigators want to learn the role of indoor environmental exposures on respiratory symptoms, and, separately, on lung function deficits in school-aged children with bronchopulmonary dysplasia (BPD).
Gender:
ALL
Ages:
Between 6 years and 12 years
Trial Updated:
09/20/2022
Locations: Boston Childrens Hospital, Boston, Massachusetts
Conditions: Bronchopulmonary Dysplasia, Chronic Lung Disease of Newborn, Environmental Exposure
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Pharmacological Activation of HMN for OSA Aim 2
NCT03858751
Recruiting
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. OSA patients show a marked reduction in upper airway (UA) dilator muscle activity at sleep onset and this phenomenon leads to increased collapsibility of UA compared to normal subjects. In this protocol the investigators will test the effect of LTM1201AZ, LTM1201AT, LTM1201AD, LTM1201AG administered before sleep on OSA phenotype traits and OSA severity during sleep.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
09/19/2022
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Obstructive Sleep Apnea
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Rare and Atypical Diabetes Network
NCT05544266
Recruiting
RADIANT is a network of 14 clinical sites and several laboratories dedicated to the study of atypical diabetes. The objective of this study is to define new forms of diabetes and the unique mechanisms underlying these forms of atypical diabetes. The specific aims are to: 1. Identify and enroll individuals and families with undiagnosed rare and atypical forms of diabetes. 2. Determine the etiologic basis of the metabolic disorder among individuals and families with novel forms of rare and atypi... Read More
Gender:
ALL
Ages:
All
Trial Updated:
09/14/2022
Locations: Massachusetts General Hospital (MGH), Boston, Massachusetts
Conditions: Diabetes Mellitus, Diabetes Mellitus Progression, Glucose Intolerance, Glucose Metabolism Disorders, Metabolic Disease, Endocrine; Complications, Endocrine System Diseases
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Folfox+Irinotecan+Chemort In Esophageal Cancer
NCT04656041
Recruiting
In this research study, is studying how Liposomal Irinotecan in combination with the standard of care interventions FOLFOX, carboplatin paclitaxel, and radiation therapy affect gastroesophageal junction or esophagogastric cancer This research study involves the following study intervention: - Liposomal irinotecan
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/07/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Gastroesophageal Junction Adenocarcinoma, Esophagogastric Cancer
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Durvalumab (MEDI4736) and Tremelimumab and Radiation Therapy in Hepatocellular Carcinoma and Biliary Tract Cancer
NCT03482102
Recruiting
This research study is studying a combination of drugs as a possible treatment for Hepatocellular Carcinoma or Biliary Tract Cancer. The interventions involved in this study are: * Durvalumab * Tremelimumab * Radiation Therapy
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/07/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Hepatocellular Carcinoma, Biliary Tract Cancer
Register for Updates
Neural Circuits for Action Perception
NCT05507320
Recruiting
Study the mechanisms underlying action recognition and execution
Gender:
ALL
Ages:
Between 14 years and 70 years
Trial Updated:
08/17/2022
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Epilepsy
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Gedatolisib Plus Fulvestrant With or Without Palbociclib vs Standard-of-Care for the Treatment of Patients With Advanced or Metastatic HR+/HER2- Breast Cancer
NCT05486143
Recruiting
This is a Phase 3, open-label, randomized, clinical trial evaluating the efficacy and safety of gedatolisib plus fulvestrant with or without palbociclib for the treatment of patients with locally advanced or metastatic HR+/HER2- breast cancer following progression on or after CDK4/6 and aromatase inhibitor therapy. Condition or disease: Breast Cancer Intervention/treatment: Drug: Gedatolisib Drug: Palbociclib Drug: Fulvestrant Drug: Alpelisib Phase 3
Gender:
All
Ages:
18 years and above
Trial Updated:
08/02/2022
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Breast Cancer
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Effect of Theophylline in Pseudohypoparathyroidism
NCT03718403
Recruiting
The study evaluates the effect of theophylline in 100 subjects with Pseudohypoparathyroidism.
Gender:
ALL
Ages:
Between 5 years and 21 years
Trial Updated:
07/20/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: PHP Ia, PHP IB, Php1C
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Kidney Precision Medicine Project
NCT04334707
Recruiting
Acute kidney injury (AKI) and chronic kidney disease (CKD) impose a significant global health burden. Yet, no effective therapies currently exist for AKI, and only a few are available for CKD. Despite significant effort from industry and academia, development of pharmacologic therapies for AKI and CKD has been hampered by: Non-predictive animal models The inability to identify and prioritize human targets The limited availability of human kidney biopsy tissue A poor understanding of AKI and CK... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/18/2022
Locations: Brigham & Women's Hospital, Boston, Massachusetts
Conditions: Acute Kidney Failure, Acute Kidney Insufficiency, Acute Renal Failure, Acute Renal Injury, Acute Renal Insufficiency, Kidney Failure, Acute, Kidney Insufficiency, Acute, Renal Failure, Acute, Renal Insufficiency, Acute, Chronic Kidney Diseases, Chronic Kidney Insufficiency, Chronic Renal Diseases, Chronic Renal Insufficiency, Kidney Insufficiency, Chronic
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CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry
NCT04688190
Recruiting
This multinational, investigator-initiated, retrospective study aims to investigate outcomes of patients, who underwent transcatheter mitral valve implantation (TMVI), in comparison to those screened for TMVI but deemed ineligible, who subsequently underwent interventional mitral valve edge-to-edge repair, mitral valve surgery or medical/conservative therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/16/2022
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Mitral Regurgitation
Register for Updates