Massachusetts is currently home to 3308 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Neuroeconomics of Social Behavior Following Trauma Exposure
NCT03383536
Recruiting
This study will use a neuroeconomic paradigm with state-of-the-art imaging protocols to probe abnormal social reward processing underlying social withdrawal in symptomatic trauma-exposed women. By also gathering self-report measures of social anhedonia, performance on non-social and social reward valuation tasks, and measures of real-world social functioning including social network size, we aim to specify how alterations in social reward processing result in social withdrawal and functional imp... Read More
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
08/29/2022
Locations: McLean Hospital, Belmont, Massachusetts
Conditions: Posttraumatic Stress Disorder
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Neuroimaging Sleep and Mood in Depression
NCT05497414
Recruiting
This study will investigate how sleep and mood are related in patients with depression and in healthy controls. It will use MRI-based measures of brain function to determine how neural systems are modulated by sleep and sleep deprivation, and its links to mood in depression.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
08/26/2022
Locations: Boston University, Boston, Massachusetts
Conditions: Major Depression
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Postoperative Pain Control Using Local Wound Infiltration in Adolescent Idiopathic Surgery
NCT04730531
Recruiting
Non-opioid methods of pain management following posterior spinal fusion (PSF) have become increasingly popular given the rise of opioid abuse and opioid-related deaths. Orthopedic surgery remains one of the highest prescribing subspecialties. Local wound infiltration is an effective method of acute pain management following surgical intervention and is the standard in some surgical subspecialties, however, no randomized control trials (RCT) exist in the pediatric spine literature. This would be... Read More
Gender:
All
Ages:
Between 10 years and 17 years
Trial Updated:
08/23/2022
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Postoperative Pain, Spinal Fusion
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Neural Circuits for Action Perception
NCT05507320
Recruiting
Study the mechanisms underlying action recognition and execution
Gender:
All
Ages:
Between 14 years and 70 years
Trial Updated:
08/17/2022
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Epilepsy
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Effect of Using Placental Membranes on Healing and Post-op Pain After Gum Surgery
NCT04957342
Recruiting
When harvesting autogenous free grafts to treat periodontal conditions (e.g., lack of attached keratinized tissue, ridge defects, and other mucogingival deformities), the hard palate is the preferred donor site. The primary disadvantage of this technique is the creation of a second surgical site. This sacrificial traumatic lesion on the palate is associated with significant post-operative morbidities, including patient discomfort, infection, inflammation, hemorrhage, and necrosis. A pilot, blin... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
08/17/2022
Locations: Harvard School of Dental Medicine, Boston, Massachusetts
Conditions: Pain, Postoperative, Gingival Diseases
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Diagnostic Accuracy and Safety of DBV1605 for the Diagnosis of Non-IgE Mediated Cow's Milk Allergy in Children
NCT04492683
Recruiting
Study to assess the diagnostic accuracy (sensitivity, specificity, positive and negative predictive value) of DBV1605 for the diagnosis of non-Immunoglobulin E (IgE) mediated cow's milk allergy (CMA) in children with symptoms suggestive of non-IgE mediated CMA.
Gender:
All
Ages:
Between 29 days and 24 months
Trial Updated:
08/09/2022
Locations: Massachusets General Hospital, Boston, Massachusetts
Conditions: Cow's Milk Allergy
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Thoracoabdominal Asynchrony and Respiratory Distress
NCT04626154
Recruiting
The investigators hypothesize that a simple 3-point tracking device that uses motion sensors attached to the abdomen and chest of a child will provide information regarding thoracoabdominal asynchrony (TAA), a major component of respiratory distress, and ultimately help guide a clinician to initiate, escalate, de-escalate, or stop respiratory support interventions. AIMS To determine if the TAA-monitoring device can be used to detect differences in respiratory synchrony in a manner that is clini... Read More
Gender:
All
Ages:
Between 28 days and 17 years
Trial Updated:
08/08/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Respiratory Insufficiency
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Salivary Profiling in Infants Treated for Suspected Sepsis: The SPITSS Study
NCT05490212
Recruiting
The aim of this study is to develop a faster, safer, and more accurate method for determining if a newborn has an infection. This study involves analyzing saliva for markers of infection and inflammation known as cytokines. We will analyze infant's saliva repeatedly for inflammatory biomarkers (cytokines) within the first 36 hours of their standard of care treatment. We hypothesize that levels of these cytokines will more quickly predict which babies are truly infected and which babies are not c... Read More
Gender:
All
Ages:
All
Trial Updated:
08/04/2022
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: Infection; Newborn
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GaitBetter: Motor and Cognitive Training for Gait Rehabilitation and Falls Prevention in Stroke Survivors.
NCT04625127
Recruiting
In this research study, the investigators aim to test the usability and efficacy of the GaitBetter system for gait rehabilitation after stroke.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
08/04/2022
Locations: Spaulding Rehabilitation Hospital Boston, Boston, Massachusetts
Conditions: Stroke, Gait, Hemiplegic, Hemiplegia
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Gedatolisib Plus Fulvestrant With or Without Palbociclib vs Standard-of-Care for the Treatment of Patients With Advanced or Metastatic HR+/HER2- Breast Cancer
NCT05486143
Recruiting
This is a Phase 3, open-label, randomized, clinical trial evaluating the efficacy and safety of gedatolisib plus fulvestrant with or without palbociclib for the treatment of patients with locally advanced or metastatic HR+/HER2- breast cancer following progression on or after CDK4/6 and aromatase inhibitor therapy. Condition or disease: Breast Cancer Intervention/treatment: Drug: Gedatolisib Drug: Palbociclib Drug: Fulvestrant Drug: Alpelisib Phase 3
Gender:
All
Ages:
18 years and above
Trial Updated:
08/02/2022
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Breast Cancer
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Incidence of Difficult Airway and Difficult Neuraxial Placement in Obstetric Patients
NCT02193542
Recruiting
Anesthesiologists commonly administer pain relief during labor or providing anesthesia for cesarean delivery. Two main methods are used to achieve these goal: "Regional anesthesia" where the mother is given medication through a needle or catheter in her back and the mother is kept awake, or "General anesthesia", where the mother is given intravenous medication and is kept asleep. Regional anesthesia uses a needle to enter a narrow space in the mother's back where medications can be given. In so... Read More
Gender:
Female
Ages:
All
Trial Updated:
08/02/2022
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Indication for Care or Intervention Related to Labor or Delivery With Baby Delivered
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Role of Dietary Habits in Efficacy of Bariatric Surgery - Study A
NCT03470558
Recruiting
The purpose of the study is to evaluate how dietary habits in the post-surgical year impact outcomes of bariatric surgery.
Gender:
All
Ages:
Between 21 years and 60 years
Trial Updated:
08/01/2022
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Bariatric Surgery, Sleeve Gastrectomy, Obesity
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