Massachusetts is currently home to 3217 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study of JK07 in Patients With Chronic Heart Failure
NCT06369298
Recruiting
This is a Phase 2, randomized, double-blind, placebo-controlled, multiple dose study to assess the safety, tolerability, and efficacy of JK07 in participants aged 18-85 with heart failure. There will be 2 cohorts in this study: Cohort 1: Heart failure (HF) participants with left ventricular ejection fraction (LVEF) of ≤ 40%. Cohort 2: Heart failure (HF) participants with left ventricular ejection fraction (LVEF) \> 40% and ≤ 65%.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
02/07/2025
Locations: Site 119, Boston, Massachusetts
Conditions: Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction
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Vedolizumab for the Treatment of Collagenous Gastritis
NCT06317220
Recruiting
The goal of this clinical trial is to learn about how vedolizumab may affect patients with collagenous gastritis (CG). The main questions it aims to answer are: * Whether vedolizumab can reduce CG symptoms * Whether vedolizumab is safe to take for patients with CG Participants in this study will: * Receive vedolizumab through an IV ("infusion") * Complete a survey at each infusion visit * Have blood collected at each infusion visit * Undergo an endoscopy with biopsy at 2 timepoints
Gender:
ALL
Ages:
14 years and above
Trial Updated:
02/07/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Collagenous Gastritis
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Pilot Study Evaluating the Impact of Stress Reduction on Atherosclerotic : Heart and Mind Study
NCT04496947
Recruiting
The plot study aims to evaluate the effect of 8 weeks of stress reducing intervention on atherosclerotic plaque inflammation in adults, as quantified by positron emission tomography (PET) with fluorine-2-deoxy-D-glucose (FDG) in individuals with increased psychosocial stress.
Gender:
ALL
Ages:
Between 30 years and 65 years
Trial Updated:
02/07/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Atherosclerosis, Stress, Inflammation
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Sensory Outcomes in Active Substance Users
NCT06639438
Recruiting
The incidence and severity of postoperative pain after spine surgery are notably high, often requiring intensive management and potentially affecting the patient's recovery, satisfaction, and long-term outcomes. Post-operative pain is particularly difficult to manage in patients with substance use disorder likely due to a combination of withdrawal symptoms and molecular changes in the pain matrix. Opiates are the leading cause of overdose related fatalities, and carry a significant burden of sub... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/06/2025
Locations: Boston Medical Center/Boston University Medical Campus, Boston, Massachusetts
Conditions: Post Operative Pain, Opioid Use, Unspecified
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Dance and Energy Expenditure Among Adults With Parkinson's
NCT06425731
Recruiting
The first purpose of the study is to develop and test new methods for quantifying dance among adults with a diagnosis of Parkinson's using various kinds of cameras, wearable activity monitors, and questionnaires. The second reason we are conducting the study is to better understand the relationship between the intensity of dance classes specifically designed for adults with Parkinson's and individual-level factors like the kinds of routine activities one does beyond dancing and one's health stat... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
02/06/2025
Locations: Northeastern University, Boston, Massachusetts
Conditions: Parkinson Disease
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LIFT: Life Improvement Trial
NCT06366724
Recruiting
The LIFT will be conducted at Brigham and Women's Hospital (BWH) of Harvard Medical School, focusing on the effect of Pyridostigmine (Mestinon) and Low-Dose Naltrexone (LDN) in subjects aged 18-65 meeting the Canadian consensus criteria (CCC) for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) as well as having specifically Orthostatic Intolerance. This double-blind, placebo-controlled study will involve 160 participants randomized into one of four possible groups: Pyridostigmine/LD... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/06/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: ME/CFS
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ED90 of Bupivacaine After Lidocaine Test Dose with DPE and EPL
NCT06146842
Recruiting
The primary objective of our study is to use a biased coin up-down allocation methodology to estimate the dose of bupivacaine required after the lidocaine test dose to achieve initial effective comfort in 90% of patients (post test-dose ED90) via the epidural (DPE or EPL) technique in women undergoing labor induction or augmentation; the investigators hypothesize that the investigators will be able to determine the post test-dose ED90 of bupivacaine for each technique with adequate precision to... Read More
Gender:
FEMALE
Ages:
All
Trial Updated:
02/06/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Labor Pain
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Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening
NCT06122077
Recruiting
The PROACT LUNG study is a prospective multi-center observational study to validate a blood-based test for the early detection of lung cancer by collecting blood samples from high-risk participants who will undergo a routine, standard-of-care screening Low-Dose Computed Tomography (LDCT).
Gender:
ALL
Ages:
50 years and above
Trial Updated:
02/06/2025
Locations: Cape Cod Hospital, Hyannis, Massachusetts
Conditions: Lung Cancer Diagnosis
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The ENERGY Study: Evaluation of Safety and Tolerability of INZ-701 in Infants With ENPP1 Deficiency or ABCC6 Deficiency
NCT05734196
Recruiting
The primary purpose of Study INZ701-104 (the ENERGY study) is to assess the safety and tolerability of INZ-701 in infants with ENPP1 Deficiency or with ABCC6 Deficiency.
Gender:
ALL
Ages:
1 year and below
Trial Updated:
02/06/2025
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency, Autosomal Recessive Hypophosphatemic Rickets, Generalized Arterial Calcification of Infancy, ATP-Binding Cassette Subfamily C Member 6 Deficiency, Pseudoxanthoma Elasticum
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Alcohol and "Heat of the Moment" Sexual Decision Making
NCT05729256
Recruiting
HIV transmission remains a significant public health concern, especially among men who have sex with men (MSM). Condomless anal intercourse (CAI) continues to be the major route of transmission for MSM. Thus, to reduce the incidence of HIV, it is critical to identify how contextual risk factors influence CAI and develop behavioral strategies that modify risk factors directly or reduce their influence on behavior. This study will examine the mechanisms through which one of the central contextual... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
02/06/2025
Locations: Boston University Department of Psychological and Brain Sciences, Boston, Massachusetts
Conditions: Alcohol Drinking, Sex, Unsafe, Hiv
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Community Reinforcement and Family Training for Early Psychosis (CRAFT-EP) and Substance Use: a Pilot Study
NCT05380583
Recruiting
The purpose of this study is to evaluate Community Reinforcement and Family Training for Early Psychosis (CRAFT-EP) for families experiencing early psychosis and substance use delivered exclusively or primarily via telehealth (video conferencing).
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
02/06/2025
Locations: McLean Hospital, Belmont, Massachusetts
Conditions: Psychosis, Substance Use, Substance Use Disorders, Family, Cannabis, Marijuana, Alcohol, Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Mental Disorder
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Testing Effects of Melatonin on Uterine Contractions in Women
NCT05358834
Recruiting
The study will extend recent discoveries that have been made in basic human physiology related to responses melatonin and uterine contractions in late- or full-term pregnant women. The basic physiology work has been conducted in in vitro models of the human myometrium characterizing its responses to melatonin, and in pilot in vivo studies correlating the number of uterine contractions with melatonin concentrations that were manipulated by different types of light exposure. The planned experiment... Read More
Gender:
FEMALE
Ages:
Between 18 years and 35 years
Trial Updated:
02/06/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Pregnant Women
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