Massachusetts is currently home to 3369 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study of Relugolix in Men With Metastatic Castration-Sensitive Prostate Cancer or Non-Metastatic or Metastatic Castration-Resistant Prostate Cancer
NCT04666129
Recruiting
This study is being conducted to assess the safety and tolerability of relugolix with other agents approved for use in combination with androgen deprivation therapy (ADT) for a 12-week treatment period and an additional 40-week safety extension period in men with prostate cancer, either metastatic castration-sensitive prostate cancer (mCSPC) or non-metastatic or metastatic castration-resistant prostate cancer (nmCRPC or mCRPC).
Gender:
Male
Ages:
18 years and above
Trial Updated:
09/02/2022
Locations: University of Massachusetts Medical School, Worcester, Massachusetts
Conditions: Metastatic Castration-Resistant Prostate Cancer, Metastatic Castration-Sensitive Prostate Cancer, Non-Metastatic Castration-Resistant Prostate Cancer
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Neuroeconomics of Social Behavior Following Trauma Exposure
NCT03383536
Recruiting
This study will use a neuroeconomic paradigm with state-of-the-art imaging protocols to probe abnormal social reward processing underlying social withdrawal in symptomatic trauma-exposed women. By also gathering self-report measures of social anhedonia, performance on non-social and social reward valuation tasks, and measures of real-world social functioning including social network size, we aim to specify how alterations in social reward processing result in social withdrawal and functional imp... Read More
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
08/29/2022
Locations: McLean Hospital, Belmont, Massachusetts
Conditions: Posttraumatic Stress Disorder
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Neuroimaging Sleep and Mood in Depression
NCT05497414
Recruiting
This study will investigate how sleep and mood are related in patients with depression and in healthy controls. It will use MRI-based measures of brain function to determine how neural systems are modulated by sleep and sleep deprivation, and its links to mood in depression.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
08/26/2022
Locations: Boston University, Boston, Massachusetts
Conditions: Major Depression
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Postoperative Pain Control Using Local Wound Infiltration in Adolescent Idiopathic Surgery
NCT04730531
Recruiting
Non-opioid methods of pain management following posterior spinal fusion (PSF) have become increasingly popular given the rise of opioid abuse and opioid-related deaths. Orthopedic surgery remains one of the highest prescribing subspecialties. Local wound infiltration is an effective method of acute pain management following surgical intervention and is the standard in some surgical subspecialties, however, no randomized control trials (RCT) exist in the pediatric spine literature. This would be... Read More
Gender:
All
Ages:
Between 10 years and 17 years
Trial Updated:
08/23/2022
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Postoperative Pain, Spinal Fusion
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FOLFIRINOX + NIS793 in Pancreatic Cancer
NCT05417386
Recruiting
This research is being done to evaluate the safety and effectiveness of the drug NIS793 in combination with the standard of care treatment FOLFIRINOX (consists of the drugs 5-Fluorouracil (5-FU), Oxaliplatin, Irinotecan, and Leucovorin), chemoradiation and surgery for people with metastatic pancreas adenocarcinoma. The drugs involved in this study are: NIS793 FOLFIRINOX (consists of the drugs 5-Fluorouracil (5-FU), Oxaliplatin, Irinotecan, and Leucovorin) Other interventions include chemorad... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/19/2022
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Pancreas Cancer, Metastatic Pancreatic Cancer, Metastatic Pancreatic Adenocarcinoma
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Neural Circuits for Action Perception
NCT05507320
Recruiting
Study the mechanisms underlying action recognition and execution
Gender:
All
Ages:
Between 14 years and 70 years
Trial Updated:
08/17/2022
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Epilepsy
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Effect of Using Placental Membranes on Healing and Post-op Pain After Gum Surgery
NCT04957342
Recruiting
When harvesting autogenous free grafts to treat periodontal conditions (e.g., lack of attached keratinized tissue, ridge defects, and other mucogingival deformities), the hard palate is the preferred donor site. The primary disadvantage of this technique is the creation of a second surgical site. This sacrificial traumatic lesion on the palate is associated with significant post-operative morbidities, including patient discomfort, infection, inflammation, hemorrhage, and necrosis. A pilot, blin... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
08/17/2022
Locations: Harvard School of Dental Medicine, Boston, Massachusetts
Conditions: Pain, Postoperative, Gingival Diseases
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Impact of a Patient-Centered Program for Low Anterior Resection Syndrome A Multicenter Randomized Controlled Trial
NCT03828318
Recruiting
After undergoing restorative proctectomy for rectal cancer, many patients are left with significant bowel dysfunction, known as Low Anterior Resection Syndrome (LARS). Increased LARS severity correlates with worse perceived global health status and quality of life (QoL). Among patients undergoing rectal resection with a permanent ostomy, there is evidence that supportive and educational interventions improve QoL, ostomy proficiency, self-efficacy and knowledge. However, evidence regarding the im... Read More
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
08/17/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Rectal Cancer, Surgery, Patient Activation, Low Anterior Resection, Low Anterior Resection Syndrome
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Pediatric Pulmonary Hypertension Network (PPHNet) Informatics Registry
NCT02249923
Recruiting
Patients are being asked to be in this research study because medical researchers hope that by gathering information about a large number of children with pulmonary hypertension over time, their understanding of the disease process will increase and lead to better treatment. Investigators believe that pulmonary hypertension in children is different than pulmonary hypertension in adults and this study will help us understand those differences.
Gender:
All
Ages:
Between 1 day and 21 years
Trial Updated:
08/10/2022
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Pulmonary Vascular Disease, Pulmonary Arterial Hypertension
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Diagnostic Accuracy and Safety of DBV1605 for the Diagnosis of Non-IgE Mediated Cow's Milk Allergy in Children
NCT04492683
Recruiting
Study to assess the diagnostic accuracy (sensitivity, specificity, positive and negative predictive value) of DBV1605 for the diagnosis of non-Immunoglobulin E (IgE) mediated cow's milk allergy (CMA) in children with symptoms suggestive of non-IgE mediated CMA.
Gender:
All
Ages:
Between 29 days and 24 months
Trial Updated:
08/09/2022
Locations: Massachusets General Hospital, Boston, Massachusetts
Conditions: Cow's Milk Allergy
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Real-Time Assessment Of Breast Cancer Lumpectomy Specimen Margins With Nonlinear Microscopy
NCT02926729
Recruiting
This research is studying a new investigative imaging instrument called a nonlinear microscope (NLM). A nonlinear microscope can produce images similar to an ordinary pathologist's microscope, but without first processing tissue to make slides. This study will determine if a NLM can be used to evaluate tissue during lumpectomy surgery for breast cancer in order to reduce the probability that standard pathologic examination of the specimen after the end of the operation will find close or positiv... Read More
Gender:
Female
Ages:
21 years and above
Trial Updated:
08/09/2022
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Breast Cancer
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Thoracoabdominal Asynchrony and Respiratory Distress
NCT04626154
Recruiting
The investigators hypothesize that a simple 3-point tracking device that uses motion sensors attached to the abdomen and chest of a child will provide information regarding thoracoabdominal asynchrony (TAA), a major component of respiratory distress, and ultimately help guide a clinician to initiate, escalate, de-escalate, or stop respiratory support interventions. AIMS To determine if the TAA-monitoring device can be used to detect differences in respiratory synchrony in a manner that is clini... Read More
Gender:
All
Ages:
Between 28 days and 17 years
Trial Updated:
08/08/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Respiratory Insufficiency
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