Massachusetts is currently home to 3310 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
The PROGRAM-study: Awake Mapping Versus Asleep Mapping Versus No Mapping for Glioblastoma Resections
NCT04708171
Recruiting
The study is designed as an international, multicenter prospective cohort study. Patients with presumed glioblastoma (GBM) in- or near eloquent areas on diagnostic MRI will be selected by neurosurgeons. Patients will be treated following one of three study arms: 1) a craniotomy where the resection boundaries for motor or language functions will be identified by the "awake" mapping technique (awake craniotomy, AC); 2) a craniotomy where the resection boundaries for motor functions will be identif... Read More
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
05/05/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Glioblastoma
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Trauma Informed Guilt Reduction Therapy
NCT02512445
Recruiting
The goal of this project is to determine if a 6-session psychotherapy intervention will help Veterans feel less deployment-related guilt and less distress related to their guilt. Half of the participants will receive the guilt focused intervention and half will receive a supportive intervention. A supplemental pilot study added in FY2021 will examine the intervention for pandemic-related guilt events.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/04/2022
Locations: National Center for PTSD, Boston, Massachusetts
Conditions: Guilt, Shame, Post-traumatic Stress Disorders
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Developing a Test for the Detection of Ovarian Cancer
NCT04794322
Recruiting
The study aims to develop a test for early detection of ovarian cancer using DNA from a growth involving the ovary found in a washing of the uterus (womb), and proteins found in the blood. The samples of the wash and the blood will be taken before surgery. After surgery, doctors will determine whether the participant had ovarian cancer or a benign disease of the ovaries. The tests of the washings and the blood will be examined to see how much the participants with ovarian cancer can be separated... Read More
Gender:
Female
Ages:
30 years and above
Trial Updated:
04/29/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Ovarian Neoplasms, Ovarian Epithelial Carcinoma, Fallopian Tube Neoplasms, High Grade Ovarian Serous Adenocarcinoma, Stage I Ovarian Cancer, Stage II Ovarian Cancer, Stage III Ovarian Cancer AJCC v8, Stage IIIA Ovarian Cancer AJCC v8, Stage IIIA1 Ovarian Cancer AJCC v8, Stage IIIA2 Ovarian Cancer AJCC v8, Stage IIIB Ovarian Cancer AJCC v8, Stage IIIC Ovarian Cancer AJCC v8, Stage IV Ovarian Cancer AJCC v8, Stage IVA Ovarian Cancer AJCC v8, Stage IVB Ovarian Cancer AJCC v8
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Machine Learning Sepsis Alert Notification Using Clinical Data
NCT04005001
Recruiting
Machine learning is a powerful method to create clinical decision support (CDS) tools, when training labels reflect the desired alert behavior. In our Phase I work for this project, we developed HindSight, an encoding software that was designed to examine discharged patients' electronic health records (EHRs), identify clinicians' sepsis treatment decisions and patient outcomes, and pass those labeled outcomes and treatment decisions to an online algorithm for retraining of our machine-learning-b... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/27/2022
Locations: Baystate Health, Springfield, Massachusetts
Conditions: Sepsis, Severe Sepsis, Septic Shock
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Bronchial NIR Image-guided Resection
NCT03097575
Recruiting
This is a clinical trial to evaluate the use of peritumoral injection of near-infrared dye indocyanine green to identify lung lesions and sentinel lymph nodes. The primary purpose is to determine if the use of ICG injected via navigational bronchoscopy, CT-guided or transthoracic allows us to identify the first lymph node that drains from the tumor, and thus would be the most likely site for metastatic disease, and remove it for analysis to improve the ability to detect tumor in this node and to... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/22/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Sentinel Lymph Node
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Neural Correlates of Stress and Perceived Control in Adolescent Depression
NCT04788524
Recruiting
Lack of perceived control, particularly during stress, has been critically implicated in major depressive disorder (MDD) and anhedonic symptoms, especially among female adolescents; yet the neural underpinnings of perceived control disruptions in MDD remain poorly understood. Using functional magnetic resonance imaging with a novel "value of control task" in conjunction with a prospective design, this study will provide a comprehensive understanding of stress and perceived control related mechan... Read More
Gender:
Female
Ages:
Between 14 years and 18 years
Trial Updated:
04/21/2022
Locations: McLean Hospital, Belmont, Massachusetts
Conditions: Major Depressive Disorder
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Near-Infrared Perfusion During Minimally Invasive Thoracic Surgery Download
NCT05346380
Recruiting
This will be a prospective, (NSR), single-center feasibility study of the Olympus VE2 NIR Imaging System to assess perfusion using NIR during minimally invasive esophagectomy and pulmonary segmentectomy. The aims of the study are: 1. To utilize NIR intraoperative imaging with the Olympus VE2 NIR Imaging System to: i. Characterize gastric conduit perfusion during esophagectomy and, ii. Identify segmental anatomy during sublobar pulmonary resection (segmentectomy) after intraoperative, intravenou... Read More
Gender:
All
Ages:
All
Trial Updated:
04/20/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Lung Neoplasms, Esophageal Lesion
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BMI-Associated Labor Induction: A Prospective Trial
NCT04035382
Recruiting
The primary objective of this study is to determine if planned induction of labor at 39 weeks for nulliparous with pre-pregnancy BMI ≥ 35 kg/m2 reduces the incidence of cesarean section compared to expectant management
Gender:
Female
Ages:
18 years and above
Trial Updated:
04/11/2022
Locations: Baystate Medical Center, Springfield, Massachusetts
Conditions: Labor Induction
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Examining Effects of Domain Specific Episodic Future Thinking on Cannabis Use
NCT05324813
Recruiting
The overarching goal of this online study is to compare the efficacy of six (weekly) sessions of Domain-Specific Episodic Future Thinking (DS-EFT) relative an active control condition on improving the ability to value future rewards and reducing cannabis use (grams and days of use), tobacco use, and alcohol use among.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/10/2022
Locations: AHP Corporate Office, Sudbury, Massachusetts
Conditions: Marijuana Use, Marijuana Dependence, Tobacco Use, Alcohol Use, Unspecified
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Paresthesia Free Spinal Cord Stimulation (PF-SCS)
NCT03670147
Recruiting
The goal is to document efficacy of PF-SCS therapy in a blinded fashion and better understand how SCS therapy works in the clinical setting. Overall the investigators hope to improve patient care and selection of candidates who have the best potential for effective pain relief from an expensive and invasive therapy.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
04/06/2022
Locations: MGH Center for Translational Pain Research, Boston, Massachusetts
Conditions: SCS, Chronic Pain
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Vagus Nerve Stimulation and Stress Reduction Training for Migraine
NCT03592329
Recruiting
This study design has two components: 1) a cross-sectional assessment of brain activity and inflammation in migraine patients compared to healthy controls and 2) an assessment of 8 weeks of a combination therapy approach to treating migraine.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
04/06/2022
Locations: Anthinoula A. Martinos Center, Charlestown, Massachusetts
Conditions: Migraine
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Biomarkers to Predict and Monitor Response to Infliximab
NCT04655729
Recruiting
The aim of the study is to generate novel minimally-invasive serum protein signatures and biomarkers in children and adolescents with Crohn's Disease (CD) that correlate with and can predict and monitor patients who will have a prolonged response to Infliximab so that personalized medicine can be applied to patients with CD.
Gender:
All
Ages:
Between 3 years and 20 years
Trial Updated:
04/05/2022
Locations: MassGeneral for Children, Boston, Massachusetts
Conditions: Crohn Disease
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