Massachusetts is currently home to 3148 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
RA-PRO PRAGMATIC TRIAL
NCT04692493
Recruiting
The 2021 ACR RA treatment guideline, based on widely acknowledged low to moderate quality evidence, recommends switching to a non-tumor necrosis factor (TNFi) biologic (choose among existing medications, currently, rituximab, abatacept, tocilizumab, or sarilumab) or a targeted synthetic DMARD arm (tsDMARD; choose among existing medications, currently, tofacitinib, baricitinib, upadacitinib) in patients with active RA despite the use of a TNFi-biologic. In practice, most patients receive another... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/01/2024
Locations: Tufts University, Boston, Massachusetts
Conditions: Rheumatoid Arthritis
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Noninvasive Brain Stimulation for Treating Carpal Tunnel Syndrome
NCT04206215
Recruiting
The purpose of this study is to assess the effects of tDCS in combination with TUS for the treatment of pain in subjects with Carpal Tunnel Syndrome. The investigators hypothesize that there will be a decrease in pain levels with active stimulation, when compared to sham stimulation.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/01/2024
Locations: Spaulding Rehabilitation Network Research Institute, Charlestown, Massachusetts
Conditions: Chronic Pain, Carpal Tunnel Syndrome
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Neoadjuvant PD-1 Inhibitor Dostarlimab (TSR-042) Vs. Combination of Tim-3 Inhibitor Cobolimab (TSR-022) and PD-1 Inhibitor Dostarlimab (TSR-042) in Melanoma
NCT04139902
Recruiting
The purpose of this study is to test the effects of anti-PI-1 inhibitor (TSR-042) or anti-PD-1/anti-TIM-3 combination (TSR-042 / TSR-022) in patients with operable melanoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/01/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Melanoma Stage III, Melanoma Stage IV
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Mapping and Quantifying Lymphatic Drainage of the Arm's Alternate Pathway
NCT05253352
Recruiting
Using indocyanine green (ICG) lymphography and lymphoscintigraphy with SPECT/CT imaging, the aim is to evaluate the anatomy of the lymphatic system pathway in two separate populations: healthy female volunteers and women with a history of breast cancer who did not develop lymphedema.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/31/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Lymphatic System
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BTX-A51 in Patients With Liposarcoma
NCT06414434
Recruiting
This study is testing if the recommended dose of BTX-A51 is safe and tolerable in participants with liposarcoma. The name of the study drug used in this research study is: -BTX-A51 (a type of kinase inhibitor)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/30/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Liposarcoma, Recurrent Liposarcoma, Metastatic Liposarcoma, Unresectable Liposarcoma, MDM2 Gene Amplification
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REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Minorities
NCT06399705
Recruiting
This is a research study in minorities to compare the outcomes of two procedures that restore blood flow to the arteries of the heart. In one procedure the blockages are ballooned and then stented with a small wire mesh tube through a small incision in the wrist or the groin. The other procedure is an open-heart operation in which healthy blood vessels from inside the chest, leg, and/or forearm are used to "bypass" the blockages (like a detour). Outcomes will be measured by comparing survival an... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/30/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Coronary Artery Disease
Register for Updates
REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Women
NCT06399692
Recruiting
This is a research study in women to compare the outcomes of two procedures that restore blood flow to the arteries of the heart. In one procedure the blockages are ballooned and then stented with a small wire mesh tube through a small incision in the wrist or the groin. The other procedure is an open-heart operation in which healthy blood vessels from inside the chest, leg, and/or forearm are used to "bypass" the blockages (like a detour). Outcomes will be measured by comparing survival and imp... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/30/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Coronary Artery Disease
Register for Updates
Intraperitoneal Cytokine-Induced Memory Like (CIML) Natural Killer (NK) Cells in Recurrent Ovarian Cancer
NCT06321484
Recruiting
The goal of this research study is to evaluate the safety and effectiveness of the use of cytokine-induced memory-like (CIML) natural killer (NK) cell therapy in recurrent, high grade ovarian cancer (HGOC). Names of the study therapies involved in this study are: CIML NK (cellular therapy) Interleukin-2 (IL-2)
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
10/30/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Platinum-resistant Ovarian Cancer, Recurrent Ovary Cancer, Ovarian Cancer, Ovarian Carcinoma, Ovarian Carcinoma, Recurrent
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Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
NCT06311708
Recruiting
This is a multicenter, non-interventional study to observe the natural progression of the disease and to study the prevalence of pre-existing antibodies to AAV9 used for gene therapy in a population of patients with PKP2 gene-associated ARVC. Participation from all patients is encouraged regardless of interest in or eligibility for gene therapy.
Gender:
ALL
Ages:
Between 14 years and 65 years
Trial Updated:
10/30/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Arrhythmogenic Right Ventricular Cardiomyopathy
Register for Updates
Smart Phone Delivered Cognitive Behavioral Therapy for Adults with Psoriasis and Co-Morbid Depression Symptoms
NCT06216691
Recruiting
A single arm, pilot study in which all eligible participants will be enrolled in an 8-week coach-guided smartphone delivered CBT program. The full duration of the program, with follow-up interview, will be 9 weeks.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/30/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Psoriasis, Depressive Symptoms
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Mechanisms of Exposure Therapy for OCD
NCT06173752
Recruiting
Exposure therapy is the most effective treatment available for obsessive compulsive disorder, yet up to 50% of patients do not recover because the mechanisms underlying successful response are poorly understood, leading to significant variability in how clinicians conduct exposure therapy. The main purpose of this study is to determine which target mechanisms are most critical to engage in real-world exposure sessions to produce good treatment outcomes. Adult participants (N = 400) with Obsessiv... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/30/2024
Locations: McLean OCDI, Belmont, Massachusetts
Conditions: Obsessive-Compulsive Disorder
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Improving Health for Older Adults with Pain Through Engagement
NCT06119698
Recruiting
The goal of this project is to conduct a randomized, hybrid type 1 effectiveness-implementation trial (N=200) to evaluate the effectiveness and implementation of a 10-week mind-body and walking program (GetActive+) vs treatment as usual (TAU). The investigators will test for improvements in self-reported, performance-based (i.e., six-minute walk test), and objective (i.e., step-count) physical function, emotional function, as well as feasibility, acceptability and implementation markers. Partici... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
10/30/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Chronic Pain, Musculoskeletal Pain
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