Massachusetts is currently home to 3148 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study to Evaluate the Efficacy and Safety of K-877-ER and CSG452 in Participants With NASH With Liver Fibrosis
NCT05327127
Recruiting
A study to investigate the use of combination therapy with two investigational products for the treatment of adult patients with Nonalcoholic steatohepatitis (NASH).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/25/2024
Locations: Boston Clinical Trial Site, Boston, Massachusetts
Conditions: NASH
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PREventing Pain After Surgery
NCT05306665
Recruiting
The present study aims to adapt and modify a brief presurgical Acceptance and Commitment Therapy (ACT) intervention aimed at preventing the transition to Chronic Post-Surgical Pain (CPSP) and reducing long-term opioid use. Investigators will then assess the acceptability, feasibility, and preliminary efficacy of the finalized intervention to prevent the transition to CPSP and reduce post-surgical opioid use six months following lumbar spine surgery. Finally, investigators will identify psychosoc... Read More
Gender:
ALL
Ages:
22 years and above
Trial Updated:
10/25/2024
Locations: Brigham and Women's Hospital, Chestnut Hill, Massachusetts
Conditions: Pain, Back, Back Injuries, Spinal Stenosis, Disc Herniation, Spondylosis, Spondylolisthesis
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Preventing Disordered Eating and Body Dissatisfaction Among High-risk Pregnant Individuals
NCT06659354
Recruiting
The investigators aim to conduct a feasibility randomized controlled trial (RCT) of an eating disorder prevention program (The Body Project, adapted for pregnancy) versus a health education control among pregnant individuals with histories of an ED. The investigators will test the feasibility, implementation outcomes, and its preliminary effectiveness in reducing the risk of elevated disordered eating and body dissatisfaction during pregnancy and postpartum.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Eating Disorders, Body Dissatisfaction
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Association of Digital Aid Use With Infant Sleep and Maternal Mental Health
NCT06593236
Recruiting
The goal of this study is to better understand the use of the Huckleberry app, a pediatric sleep guidance app and the impacts on infant sleep and maternal mental health.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: UMass Chan Medical School, Worcester, Massachusetts
Conditions: Infant Development, Maternal Behavior
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Phase 2 Study of KH001 in Long-term Relief from Dentin Hypersensitivity
NCT06464939
Recruiting
The purpose of this study is to evaluate the efficacy and safety of KH001 in subjects with dentin hypersensitivity.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: ADA Forsyth, Cambridge, Massachusetts
Conditions: Dentin Hypersensitivity
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A Novel, Regulated Gene Therapy (NGN-401) Study for Female Children with Rett Syndrome
NCT05898620
Recruiting
This study will evaluate the safety profile of the investigational gene therapy, NGN-401, in female children with typical Rett syndrome.
Gender:
FEMALE
Ages:
Between 4 years and 10 years
Trial Updated:
10/24/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Rett Syndrome
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Preventing Liver Cancer Mortality Through Imaging With Ultrasound vs. MRI
NCT05486572
Recruiting
The study is a randomized trial of two different screening methods for early detection of liver cancer in patients with cirrhosis of the liver. The goal of PREMIUM is to compare an abbreviated version of the diagnostic gold standard for HCC (aMRI) +AFP to the standard-of-care screening (US+AFP) in patients at high risk of developing HCC. The investigators hypothesize that HCC will be detected at earlier stages, allowing for more curative treatments and resulting in a reduction in HCC-related mor... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
10/24/2024
Locations: VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts
Conditions: Carcinoma, Hepatocellular, Cirrhosis
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Phase I Trial to Evaluate VLP Peanut in Healthy and Peanut Allergic Subjects
NCT05476497
Recruiting
This phase I clinical trial is designed to evaluate the safety and tolerability of VLP Peanut in healthy subjects and in subjects with peanut allergy (PA). This clinical trial will evaluate the immunotoxicity profile of VLP Peanut in healthy subjects and assess the immunotoxicity profile and the degree of reactogenicity (allergenicity) in subjects with PA. This clinical trial will also explore preliminary proof of efficacy of VLP Peanut in subjects with PA.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
10/24/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Peanut Allergy
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FMT in Uncomplicated Diverticulitis
NCT05373784
Recruiting
Fecal Microbiota Transplantation (FMT) is an established treatment for Clostridium difficile (C. diff) infection refractory to medical management. As C. diff infection usually arises due to significant disturbances in the gut microbiome, FMT is typically performed to restore a healthy microbiome among affected patients who have failed other treatments. Diverticulitis is a major, and often recurrent, source of morbidity in the U.S for which antibiotics and surgical resection constitute the only t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: UMASS Memorial Medical Center, Worcester, Massachusetts
Conditions: Diverticulitis, Uncomplicated Diverticular Disease
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Natural History Study of Individuals With Autism and Germline Heterozygous PTEN Mutations
NCT02461446
Recruiting
The purpose of this study is to determine cross-sectional and longitudinal medical, behavioral, and cognitive differences between PTEN ASD and other groups, as well as to identify cognitive, neural systems, and molecular biomarkers specific to PTEN ASD. In addition, this study will be creating and maintaining a biorepository and linked phenotypic database for PTEN ASD.
Gender:
ALL
Ages:
18 months and above
Trial Updated:
10/24/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: PTEN, ASD, Autism, Macrocephaly, PTEN Hamartoma Tumor Syndrome
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The Study Assessing the Safety and Efficacy of OK-101 Treatment in Subjects With Neuropathic Corneal Pain
NCT06637527
Recruiting
The primary objective of this study, in subjects with Neuropathic Corneal Pain, is to evaluate the efficacy and safety of OK-101 0.05% and 0.1% as compared to placebo instilled 4 times/day in subjects with neuropathic corneal pain, as assessed by visual analogue scale (VAS).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/23/2024
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: Neuropathic Pain
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PD-L1 T-haNK, N-803 IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC
NCT06239220
Recruiting
The purpose of this research study is to test the safety and efficacy of the combination of PD-L1 t-haNK (modified immune cells), N-803 (a manufactured protein that stimulates the immune system), and cetuximab (a targeted antibody) in treating advanced head and neck cancer. The names of the therapies involved in this study are: * PD-L1 t-haNK cell therapy (a NK cell therapy infusion) * N-803 (a type of recombinant human superagonist) * Cetuximab (a type of antibody)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/23/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma, Metastatic Head and Neck Cancer, Recurrent Head and Neck Cancer, Metastatic Head-and-neck Squamous-cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma
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