Massachusetts is currently home to 3199 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Improving Preschool Outcomes by Addressing Maternal Depression in Head Start
NCT04092010
Recruiting
Within a research network of Head Start centers in Massachusetts, an efficacy trial of a stepped-care intervention (SCI) to address maternal depression, using intervention components that both prevent depression and help those in major depressive episode (MDE) engage with care, will be conducted. Both the prevention and engagement components of the model have strong, supportive randomized trial evidence for both their efficacy and safety; but they have yet to be synthesized and tested within a c... Read More
Gender:
FEMALE
Ages:
All
Trial Updated:
12/06/2024
Locations: Boston Medical Center, Boston, Massachusetts
Conditions: Maternal Depression
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Brain Oxygen Optimization in Severe TBI, Phase 3
NCT03754114
Recruiting
BOOST3 is a randomized clinical trial to determine the comparative effectiveness of two strategies for monitoring and treating patients with traumatic brain injury (TBI) in the intensive care unit (ICU). The study will determine the safety and efficacy of a strategy guided by treatment goals based on both intracranial pressure (ICP) and brain tissue oxygen (PbtO2) as compared to a strategy guided by treatment goals based on ICP monitoring alone. Both of these alternative strategies are used in s... Read More
Gender:
ALL
Ages:
14 years and above
Trial Updated:
12/06/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Brain Injuries, Traumatic
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Prostate Active Surveillance Study
NCT00756665
Recruiting
The Prostate Active Surveillance Study (PASS) is a research study for men who have chosen active surveillance as a management plan for their prostate cancer. Active surveillance is defined as close monitoring of prostate cancer with the offer of treatment if there are changes in test results. This study seeks to discover markers that will identify cancers that are more aggressive from those tumors that grow slowly.
Gender:
MALE
Ages:
21 years and above
Trial Updated:
12/06/2024
Locations: Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts
Conditions: Prostatic Neoplasms
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Evaluating Interventions for Intimate Partner Violence Use in Washington State
NCT06526247
Recruiting
Intimate partner violence (IPV), specifically physical and psychological aggression toward an intimate partner, represents a public health crisis that affects millions of Americans each year. There currently exists very little evidence from randomized controlled trials for the effectiveness of abuser intervention programs designed to prevent and end perpetration of IPV in the general population. This is troubling considering that approximately half a million men and women are court-mandated to t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: BU Chobanian & Avedisian School of Medicine, Psychiatry, Boston, Massachusetts
Conditions: Intimate Partner Violence
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Study of Safety and Efficacy of RGT-61159 in Adults with Relapsed/Refractory Adenoid Cystic Carcinoma (ACC) or Colorectal Carcinoma (CRC)
NCT06462183
Recruiting
Phase 1 study to evaluate safety, tolerability and anti-tumor activity of RGT-61159 in patients with ACC or CRC
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Adenoid Cystic Carcinoma, Colorectal Cancer
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Aging Well Through Interactions and Scientific Education - Action Plan (AgeWISE-AP)
NCT06006962
Recruiting
The purpose of this study is to learn about the effects of AgeWISE-Action Plan (AgeWISE-AP), a 20-week program designed to provide education and individualized planning with a goal of improving brain health.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
12/05/2024
Locations: VA Bedford HealthCare System, Bedford, MA, Bedford, Massachusetts
Conditions: Cognitive Aging
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US National OCS Heart Perfusion (OHP) Registry
NCT05915299
Recruiting
This Registry is a sponsor initiated, multi-center, observational post-approval registry with independent academic oversight.
Gender:
ALL
Ages:
All
Trial Updated:
12/05/2024
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: Heart Transplant
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Adjunctive Motivational Alcohol Intervention to Prevent IPV
NCT05287711
Recruiting
This is a study to provide much-needed experimental data on the efficacy of a brief alcohol Motivational Enhancement Therapy (MET) pre-group intervention for Veterans receiving group treatment for IPV perpetration. The investigators will compare those assigned to receive this 2-session MET intervention to those receiving a 2-session Alcohol Education (AE) intervention or a 2-session standard treatment as usual (TAU) telephone monitoring intervention. The investigators will examine whether MET le... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts
Conditions: Alcohol Use and Intimate Partner Violence
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Stroke Thrombectomy and Aneurysm Registry
NCT04994756
Recruiting
This international multi-center registry is used to collect existing information and outcomes for patients undergoing an operation for treatment of injuries to the brain including the blockage of blood flow to an area of the brain, an abnormal ballooning of an artery, abnormal tangling of blood vessels, abnormal formation of blood vessels, tearing of vein, and bleeding in the brain. This information is used to help predict outcomes that undergo an operation for treatment of the above-listed brai... Read More
Gender:
ALL
Ages:
Between 1 year and 120 years
Trial Updated:
12/05/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Stroke, Thromboses, Intracranial, Aneurysm, Brain
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Vaginal Microbiota Transplant
NCT04046900
Recruiting
This is a randomized trial of vaginal microbiome transplant vs. saline placebo to restore a Lactobacillus dominant vaginal microbial community in women with recurrent bacterial vaginosis.
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
12/05/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Recurrent Bacterial Vaginosis
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Resistance and Aerobic Exercise for Prevention in Women With Dense Breasts (REP-D)
NCT06322888
Recruiting
The goal of this study is to learn more about how exercise might lower the risk of developing breast cancer in women with dense breast tissue by studying changes that occur in breast tissue and blood as a result of participating in an exercise program. The names of the study groups in this study are: * Exercise Training Group * Waitlist Control Group
Gender:
FEMALE
Ages:
Between 18 years and 59 years
Trial Updated:
12/04/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Breast Cancer, Breast Cancer Female
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Effect of Short-chain Fatty Acids on Aerobic Endurance
NCT06054607
Recruiting
Randomized, double-blind, placebo-controlled crossover study designed to determine the effects of increasing colonic short-chain fatty acid (SCFA) content on aerobic endurance in healthy adults, and to identify underpinning mechanisms. In random order, healthy physically active adults will consume provided diets low in fiber and supplemented with SCFA-enriched high amylose maize starch (a poorly digested resistant starch considered a fermentable fiber) or low amylose maize starch (a rapidly dige... Read More
Gender:
ALL
Ages:
Between 17 years and 39 years
Trial Updated:
12/04/2024
Locations: United States Army Research Institute of Environmental Medicine, Natick, Massachusetts
Conditions: Aerobic Endurance, Metabolism
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