Massachusetts is currently home to 3204 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Parents Advancing Toddler Health
NCT04824989
Recruiting
Although early interventions can improve health equity in young children living in poverty, this promise often is not realized because of barriers to family engagement. The proposed study will target co-morbid behavior and sleep problems in early childhood, comparing child outcomes and family response to sleep and behavior interventions and investigating the novel strategy of letting families select their intervention.We will enroll 500 low-income toddlers with co-morbid sleep and behavior probl... Read More
Gender:
ALL
Ages:
Between 18 months and 48 months
Trial Updated:
04/01/2022
Locations: Boston University, Boston, Massachusetts
Conditions: Sleep Problem, Behavior, Child
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Non Exudative AMD Imaged With SS-OCT- Extension
NCT04469140
Recruiting
The investigators wish to better understand the role of the choriocapillaris (CC) in the formation and progression of non-exudative in age related macular degeneration (armd) by imaging the retinal pigment epithelium (rpe) and the choroidal microvasculature and by studying their inter-dependence to determine if the loss of the CC could prove useful as an anatomic clinical trial endpoint in future drug trials.
Gender:
ALL
Ages:
All
Trial Updated:
03/08/2022
Locations: New England Eye Center/Tufts Medical Center, Boston, Massachusetts
Conditions: Dry Macular Degeneration
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Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL
NCT05211856
Recruiting
The purpose of this study is to evaluate the efficacy and safety of acalabrutinib in combination with venetoclax and acalabrutinib in combination with venetoclax with and without obinutuzumab compared to chemoimmunotherapy in subjects with previously untreated CLL.
Gender:
All
Ages:
Between 18 years and 130 years
Trial Updated:
01/14/2022
Locations: Research Site, Boston, Massachusetts
Conditions: Chronic Lymphocytic Leukemia
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FDG an Myocardial Infarction: The PIAF Trial
NCT05138718
Recruiting
In order to define distinct and reliable arterial 18Fluorodeoxyglucose (FDG) thresholds identifying patients at risk for cardiovascular events, patients with a history of myocardial infarction will be included in this international multicenter trial. Non-enhanced whole-body FDG PET/CT will be performed in all patients and the arterial FDG uptake in the carotid arteries as well as the aorta will be quantified by calculating different uptake parameters. In addition, FDG uptake in hematopoietic tis... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/30/2021
Locations: Massachusetts General Hospital, Havard Medical School, Boston, Massachusetts
Conditions: History of Myocardial Infarction
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LEAD IT! An App to Enable Persons With Early Stage Dementia to Lead Group Activities for Their Peers
NCT04899973
Recruiting
The proposed Phase 2 project will involve the further development and evaluation of LEAD IT!, which is a tablet-based app designed to enable persons with dementia to lead activities for their peers (i.e., other persons with dementia). The study will examine the clinical outcomes of long-term use of the app by both Resident Leaders (RLs) and Resident Players (RPs). The Specific Aims of the proposed Phase 2 project are to: Develop improved Beta 1 and Beta 2 Versions of LEAD IT! with sufficient c... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/30/2021
Locations: Hearthstone Alzheimer Care, Winchester, Massachusetts
Conditions: Dementia, Alzheimer Disease
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The HALT Biomarker Study
NCT04552275
Recruiting
The purpose of the HALT Biomarkers study are to identify a panel of circulating proteins that discriminates between patients with and without Hypo-Attenuated Leaflet Thickening (HALT) and can be used to supplement the diagnosis of HALT; to characterize changes in circulating proteins after treatment of HALT with systemic anticoagulation; and to identify circulating proteins that predict the occurrence of HALT. The study population will be adult patients undergoing transfemoral transcatheter aor... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
11/02/2021
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Aortic Stenosis, Hypo-attenuated Leaflet Thickening, Bioprosthetic Valve Degeneration
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Management of Esophagitis Following Repair of Esophageal Atresia
NCT03619408
Recruiting
The goal of this study is to prospectively evaluate the impact of antacid therapy on esophagitis in children with repaired esophageal atresia. Recent clinical guidelines have attempted to define a systematic approach to the management of these patients with regards to minimizing and treating esophagitis (Krishnan et al 2016), however the quality of evidence supporting many of the recommendations are based on expert opinion or on limited, retrospective studies. Risk factors for esophagitis and op... Read More
Gender:
ALL
Ages:
Between 30 days and 17 years
Trial Updated:
09/02/2021
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Esophageal Atresia, Esophagitis
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9-month Study to Assess the Efficacy of Ofatumumab on Microglia in Patients With Relapsing Forms of Multiple Sclerosis
NCT04510220
Recruiting
We aim to assess the effect of Ofatumumab on microglial activation using \[F-18\]PBR06 PET in MS patients in relation to changes in serum markers, MRI abnormalities and clinical impairment longitudinally over 9 months. Specific Aims: Specific Aim 1: To determine the effect of Ofatumumab on microglial activation in MS over 9 months. Specific Aim 2: To determine the time course of effect of Ofatumumab on microglial activation and its relationship with peripheral B-cell depletion, serum neurofil... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
07/20/2021
Locations: Partners MS Center, 60 Fenwood Road, Boston, Massachusetts
Conditions: Relapsing Multiple Sclerosis
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Cognition and the Immunology of Postoperative Outcomes
NCT04792983
Recruiting
This research will test the hypothesis that immune system disequilibrium / dysfunction explains why preoperative cognitive impairment is a strong predictor of postoperative morbidity in older surgical patients. The investigators propose that cognitive impairment influences surgical morbidity because of underlying immune disequilibrium / dysfunction (risk marker) and that this shapes the immune response to surgery and defines immunological hallmarks of postoperative morbidity (disease marker). Th... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
03/10/2021
Locations: Brigham & Women's Hospital, Boston, Massachusetts
Conditions: Cognitive Impairment, Frail Elderly Syndrome, Delirium, Surgery
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Proton or Photon RT for Retroperitoneal Sarcomas
NCT01659203
Recruiting
This research study is a Phase I clinical trial. Phase I clinical trials test the safety of an investigational intervention. Phase I studies also try to define the appropriate dose of the investigational therapy to use for further studies. "Investigational" means that the intervention is still being studied and that research doctors are trying to find out more about it. Retroperitoneal sarcomas are soft tissue tumors located at the far back of the abdomen. Typically, patients with retroperitone... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/01/2020
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Retroperitoneal Sarcoma
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Biocellular-Cellular Regenerative Treatment Scaring Alopecia and Alopecia Areata
NCT03078686
Recruiting
The primary objective of this study is to evaluate the safety and efficacy of the use of a biocellular mixture of emulsified adipose-derived tissue stromal vascular fraction (AD-tSVF) and high density platelet-rich plasma concentrate (HD- PRP). Additionally, comparison with clinical outcomes of adipose-derived cellular Stromal Vascular Fraction (AD-cSVF) + AD-tSVF + HD PRP; AD-cSVF + emulsified AD-tSVF + HD- PRP; emulsified AD-tSVF + HD PRP + AD-cSVF; AD-cSVF via intravenous infusion in treatmen... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/15/2020
Locations: Regeneris Medical, North Attleboro, Massachusetts
Conditions: Alopecia Areata, Scarring Alopecia
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REtroperitoneal SArcoma Registry: an International Prospective Initiative
NCT03838718
Recruiting
Surgery is currently the only potentially curative treatment modality for localized retroperitoneal sarcoma (RPS). Available studies regarding oncologic outcomes are mainly retrospective in nature, and RPS are recognized as a rare disease. Therefore, prospective analysis of high quality data is a top priority. Primary Objectives of this study are: * to prospectively collect standardized clinical data and radiological and pathological material from primary RPS patients treated with surgery at r... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/11/2019
Locations: Brigham and Women's Hospital/Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Retroperitoneal Sarcoma
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