Massachusetts is currently home to 3204 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Employment Support After Hematopoietic Stem Cell Transplantation
NCT06494423
Recruiting
This is a feasibility study of a Work Support (WorkS) intervention designed to ameliorate employment challenges for people preparing to return to work after allogeneic stem cell transplantation. The aim of this study is to evaluate "proof of concept" by: 1. examining the feasibility and acceptability of the WorkS intervention and the study procedures, and 2. exploring the preliminary effects of WorkS for improving patient-reported return-to-work self-efficacy, work status, quality of life, and... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
11/18/2024
Locations: MGH Cancer Center, Boston, Massachusetts
Conditions: Hematopoietic Stem Cell Transplantation
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Web-administered STAIR for Patients on Behavioral Health Waitlists
NCT06431022
Recruiting
Posttraumatic stress disorder (PTSD) is a significant public health challenge with population prevalence rates in the US between 6.1 to 9.2%. There are large racial and socioeconomic inequities in access to PTSD treatment, as up to half (30-50%) of patients in safety net clinical settings meet criteria for PTSD, yet only 13% receive any behavioral health treatment. Workforce shortages are one major barrier to accessing care. Additional barriers to care can include heightened mental health stigma... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: Boston Medical Center, Boston, Massachusetts
Conditions: Post Traumatic Stress Disorder
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Language During Inhalational Induction
NCT06324955
Recruiting
The aim of this study is to compare the impact of common (standard of care) language vs positive language used by clinicians during inhalational induction of anesthesia on anxiety and negative behaviors in children. This is a prospective randomized parallel group trial. Patients will be randomized 1:1 to the common/standard language group or the positive language group.
Gender:
ALL
Ages:
Between 5 years and 10 years
Trial Updated:
11/18/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Emergence Delirium, Anesthesia; Adverse Effect
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Evaluation of Sinus Augmentation Bone Healing Using Autograft and Xenograft Compared to Xenograft Alone
NCT06247098
Recruiting
To evaluate bone healing at 4 months after lateral sinus augmentation with a 4:1 ratio of autologous bone and xenograft or xenograft alone. A radiographic volumetric, histomorphometric, and histologic analysis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: Tufts University School of Dental Medicine, Boston, Massachusetts
Conditions: Maxillary Sinus Floor Augmentation, Dental Implant, Bone Substitute, Autogenous Bone Graft
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Optimal Stimulation Parameters to Disrupt Epileptiform Activity
NCT06141668
Recruiting
Open-loop electrical stimulation has been found to reduce spike activity and seizures, but determining the optimal parameters to achieve these effects requires a brute force trial-and-error approach that relies on subjective physician discretion. We will compare the performance of stimulation parameters identified in rodent models to the recommended parameters for neuromodulation used in clinical practice.
Gender:
ALL
Ages:
All
Trial Updated:
11/18/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Refractory Epilepsy
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Lentiviral Gene Therapy (Zamtocabtagene Autoleucel) LTFU
NCT06116110
Recruiting
This is an observational long-term follow-up (LTFU) study for subjects who previously received zamtocabtagene autoleucel, known as MB-CART2019.1.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Non Hodgkin Lymphoma
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Comparative Effectiveness of Individual Versus Group-Level Interventions to Reduce Human Immunodeficiency Virus (HIV)/ Sexually Transmitted Infections (STI) Incidence
NCT06022809
Recruiting
The HIV diagnosis rate among African-born Black women is the highest of all Black individuals living in the US. Correct and consistent use of condoms and use of pre-exposure prophylaxis (PrEP) are two effective means of decreasing HIV risk among women, but they remain suboptimal among Black women. The specific aims of this study are: 1. To culturally adapt two widely utilized, evidence-based HIV prevention interventions originally designed for US born Black women (Sister-to-Sister (S2S) and Si... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
11/18/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: HIV, Other STIs
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Effect of PRP, PPP, & BMAC on Functional Outcomes Following Hip Arthroscopy for Acetabular Labral Pathologies
NCT06003101
Recruiting
The goal of this clinical trial is to assess the effect of PRP/PPP/BMAC application on functional outcomes after hip arthroscopy to address acetabular labral pathologies. The main questions it aims to answer are: 1. Does PRP/PPP/BMAC application improve functional outcomes after hip arthroscopy to address acetabular labral pathologies? 2. Does PRP/PPP/BMAC application reduce the arthritic burden as measured by functional outcomes following hip arthroscopy to address labral pathologies with conc... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Acetabular Labrum Tear, Femoro Acetabular Impingement, Chondral Defect, Bone Marrow Aspirate Concentrate
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REACH-Es: Adapting a Digital Health Tool to Improve Diabetes Medication Adherence Among Latino Adults
NCT06000813
Recruiting
Latino individuals, the fastest growing ethnic minority population in the United States, have a higher prevalence of type 2 diabetes and diabetes-related complications, and are more likely to report inconsistent use of diabetes medications than non-Hispanic White individuals. The proposed project will test an interactive text message-based tool tailored to address barriers to taking diabetes medications that are relevant to Latino adults. If found feasible, acceptable, and usable, this intervent... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: Massachusetts General Hospital Diabetes Research Center, Boston, Massachusetts
Conditions: Type 2 Diabetes (Adult Onset), Medication Adherence
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NeuroPathways Intervention for Brain Tumor Patients
NCT05976490
Recruiting
This goal of this study is to test an information and support intervention for patients with malignant (or "high-grade") brain tumors. This study was developed to help patients cope after a brain tumor diagnosis. The main question this study aims to answer is whether this intervention (which includes access to an information guide and one-on-one coaching sessions) is feasible (i.e., possible to carry out) and acceptable (i.e., considered helpful) to patients. Participants will be asked to take p... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Malignant Brain Tumor, Glioma, Coping Skills
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A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration (FTLD) Syndromes
NCT05956834
Recruiting
The primary objective of this study is to enroll an observational cohort of approximately 60 patients with PSP over the course of 24 months using a multicenter study design and to follow each of them for 12 months. The secondary objective of this study is to develop a robust solution for multi-modal remote monitoring of motor symptoms and function in PSP that can be applied to other Frontotemporal lobar degeneration (FTLD) syndromes.
Gender:
ALL
Ages:
Between 40 years and 89 years
Trial Updated:
11/18/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: PSP, CBD, Progressive Supranuclear Palsy, FTD, Corticobasal Degeneration, Frontotemporal Dementia, Frontotemporal Lobar Degeneration
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Modulation of Brain Oscillations Underlying Working Memory
NCT05923606
Recruiting
This study will use novel transcranial alternating current stimulation (tACS) protocols and electroencephalography (EEG) to modulate and measure brain oscillations that underlie working memory. tACS is a noninvasive method used to modulate the timing and patterns of brain rhythms via weak electric currents passed through electrodes on the scalp.
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
11/18/2024
Locations: Martinos Center for Biomedical Imaging, Charlestown, Massachusetts
Conditions: Working Memory
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