Massachusetts is currently home to 3212 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer
NCT03678025
Recruiting
This phase III trial studies how well standard systemic therapy with or without definitive treatment (prostate removal surgery or radiation therapy) works in treating participants with prostate cancer that has spread to other places in the body. Addition of prostate removal surgery or radiation therapy to standard systemic therapy for prostate cancer may lower the chance of the cancer growing or spreading.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
08/14/2024
Locations: Lahey Hospital and Medical Center, Burlington, Massachusetts
Conditions: Castration Levels of Testosterone, Metastatic Prostatic Adenocarcinoma, Stage IV Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8, Stage IVB Prostate Cancer AJCC v8
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The Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of HMPL-523 in Adult Subjects With Immune Thrombocytopenia (ITP)
NCT06291415
Recruiting
This is an open-label, multicenter study to evaluate the safety, tolerability, and efficacy of HMPL-523 in adult subjects with ITP.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Immune Thrombocytopenia, Blood Platelet Disorder, Hematologic Diseases, Purpura, Thrombocytopenic, Purpura, Blood Coagulation Disorder, Thrombotic Microangiopathies, Hemorrhagic Disorders, Autoimmune Diseases, Immune System Diseases, Hemorrhage, Pathologic Processes, Skin Manifestations, Thrombocytopenia, Purpura, Thrombocytopenic, Idiopathic, Primary Immune Thrombocytopenia, ITP - Immune Thrombocytopenia
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Mobile App-based Approach for Reducing Pain and Hazardous Drinking: a Pilot Study
NCT06281821
Recruiting
Chronic pain and heavy drinking are common co-occurring conditions among patients presenting to primary care settings. Given their impact on functioning and medical outcomes, there would be considerable benefit to developing an accessible, easily utilized, integrative approach to reduce alcohol use and pain that can be readily incorporated into the health care settings. The objective of this study is to test a modified version of a smartphone-based intervention for reducing pain and alcohol use... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2024
Locations: Boston University, Boston, Massachusetts
Conditions: Alcohol Drinking, Chronic Pain
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First Face Training Evaluation in Tribal Communities
NCT05998005
Recruiting
The goal of this study is to evaluate a culturally grounded training curriculum, First Face for Mental Health, in Tribal communities, using a waitlist controlled trial design. This curriculum will train Tribal community members in how to respond to youth and adults experiencing mental health crises and serve as a bridge between these individuals and the help they need. The main questions the study aims to answer are: * Does the training increase mental health knowledge, capacity and ability to... Read More
Gender:
ALL
Ages:
14 years and above
Trial Updated:
08/13/2024
Locations: Division on Addiction, Cambridge Health Alliance, Malden, Massachusetts
Conditions: Mental Health, Substance-Related Disorders
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US National OCS Liver Perfusion (OLP) Registry
NCT05940857
Recruiting
This Registry is a sponsor-initiated, multi-center, observational, post-approval registry with an independent academic oversight. TransMedics has contracted with United Network for Organ Sharing (UNOS) the Federal manager of the U.S. national transplant outcomes registry to obtain data that is routinely collected by the Organ Procurement and Transplantation Network (OPTN) on all transplanted organs in the U.S. for both the OCS liver transplanted patients as well as patients transplanted using o... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/13/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Liver Transplant
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The PRECISION II Study: Evaluating the Accuracy of the LabPatch Glucose Sensing System
NCT05754281
Recruiting
The purpose of this study is to evaluate the accuracy of the Cambridge Medical Technologies, LLC second generation (2nd Gen) LabPatch glucose sensing system compared to a laboratory glucose analyzer (YSI 2300 STAT Plus) and 2 commercial glucometers, OneTouch Verio and Freestyle Lite. The primary endpoint of this study is the mean absolute relative difference (MARD) for 2nd Gen LabPatch system compared to each of the above mentioned glucose references over a 6 hour outpatient visit.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/13/2024
Locations: Joslin Diabetes Center, Boston, Massachusetts
Conditions: Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
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Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)
NCT05658913
Recruiting
To collect Tau PET/CT imaging in older adults diagnosed with Mild Cognitive Impairment (MCI) or Alzheimer's Disease (AD) in the Mismatch Prospective Cohort Study (MPC-Tau) study to determine relationship to clinical, cognitive, and other biomarker data. Findings from this study will likely provide insight into the phenotypic variability of Alzheimer's Disease and other related pathologies.
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
08/13/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Alzheimer's Disease
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Child and Adolescent Registry for Participants With Narcolepsy
NCT04899947
Recruiting
CATNAP is a patient registry designed to improve the understanding of the natural history of narcolepsy in pediatric patients. Descriptive statistics on disease characteristics will be performed. The study has 16 active clinical sites and a virtual site that widens participation to anywhere in the United States. For more information about the study or to access the Online Patient Enrollment System, visit the CATNAP website: https://catnap.healthie.net/welcome or email catnap@pulseinfoframe.com.... Read More
Gender:
ALL
Ages:
17 years and below
Trial Updated:
08/13/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Narcolepsy
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Treatment of Brain AVMs (TOBAS) Study
NCT02098252
Recruiting
The objectives of this study and registry are to offer the best management possible for patients with brain arteriovenous malformations (AVMs) (ruptured or unruptured) in terms of long-term outcomes, despite the presence of uncertainty. Management may include interventional therapy (with endovascular procedures, neurosurgery, or radiotherapy, alone or in combination) or conservative management. The trial has been designed to test a) whether medical management or interventional therapy will redu... Read More
Gender:
ALL
Ages:
5 years and above
Trial Updated:
08/13/2024
Locations: Boston Medical Center, Boston, Massachusetts
Conditions: Unruptured Brain Arteriovenous Malformation, Ruptured Brain Arteriovenous Malformation, Arteriovenous Malformations, AVM, BAVM
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A Phase II Study of Cyberknife Radiosurgery for Renal Cell Carcinoma
NCT01890590
Recruiting
CyberKnife Based Radiosurgery is a way to deliver large doses of radiation very accurately to a tumor. The ability of this technology to minimize radiation dose to organs adjacent to the target tumor allows a high dose to be delivered to the tumor, thus potentially increasing the efficacy of radiation treatment. Currently, radiosurgery is commonly used for brain metastases, Stage I lung cancer, spine tumors, and localized prostate cancer. The purpose of this protocol is to evaluate the role of R... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Renal Cell Carcinoma
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General Pre-Trial Screening Protocol for Infectious Diseases Research
NCT06463704
Recruiting
The purpose of this general screening protocol is to facilitate recruitment into studies conducted at the Center for Virology and Vaccine Research (CVVR) or Division of Infectious Diseases at Beth Israel Deaconess Medical Center. This general screening protocol will help to determine the eligibility of potential volunteers for any vaccine or therapeutic trials open for recruitment or soon to be opened.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/12/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Healthy Volunteers
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Predicting Language and Literacy Growth in Children With ASD Using Statistical Learning
NCT06332144
Recruiting
The goal of this observational study is to test a reciprocal relationship between statistical learning and the development of language and literacy in first-graders with autism and their non-autistic peers. The main questions it aims to answer are: 1. whether children's statistical learning abilities can predict their long-term improvement of language and literacy skills in school; 2. how children's brains automatically learn patterns from speech and prints; 3. whether children's learning in th... Read More
Gender:
ALL
Ages:
Between 72 months and 90 months
Trial Updated:
08/12/2024
Locations: Northeastern University, Boston, Massachusetts
Conditions: Autism Spectrum Disorder, Language Development, Literacy
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